|
7,652
|
| 76623 |
Vitamin B12
|
|
increases_quantity of
|
Cobamide coenzyme
|
in mitochondria; via adenosylation through MMAB
|
| 76624 |
Vitamin B12
|
|
increases_quantity of
|
Methylcobalamin
|
in cytoplasm
|
| 76625 |
Cobamide coenzyme
|
|
increases_activity of
|
MMUT
|
|
| 76627 |
MMUT
|
|
decreases_quantity of
|
Methylmalonyl-CoA
|
|
| 76628 |
MMUT
|
|
increases_quantity of
|
Succinyl-CoA
|
|
| 76632 |
Succinyl-CoA
|
|
affects_activity of
|
tricarboxylic acid cycle
|
|
| 76637 |
Methylmalonyl-CoA
|
|
increases_quantity of
|
Methylmalonate
|
|
| 76790 |
Methylmalonyl-CoA
|
|
increases_quantity of
|
Succinyl-CoA
|
|
| 77081 |
MMUT
|
|
affects_activity of
|
Methylmalonic aciduria, mut(0/-) type
|
|
| 77181 |
MMUT
|
|
is localized in
|
mitochondrion
|
|
|
22661206
|
Metabolic
Methylmalonic aciduria
|
|
7,659
|
| 76668 |
LMBRD1
|
|
increases_transport of
|
Vitamin B12
|
from lysosomes to cytosol
|
| 76669 |
ABCD4
|
|
increases_transport of
|
Vitamin B12
|
from lysosomes to cytosol
|
| 76671 |
LMBRD1
|
|
affects_activity of
|
Methylmalonic aciduria and homocystinuria, cblF type
|
|
| 76672 |
ABCD4
|
|
affects_activity of
|
Methylmalonic aciduria and homocystinuria, cblJ type
|
|
| 76683 |
MMACHC
|
|
interacts (colocalizes) with
|
Vitamin B12
|
in the cytoplasm
|
| 76684 |
MMACHC
|
|
interacts (colocalizes) with
|
MMADHC
|
in the cytoplasm; This interaction facilitates binding of Vitamin B12 to methionine synthase
|
| 76702 |
MMAB
|
|
increases_quantity of
|
Cobamide coenzyme
|
in mitochondria; via adenosylation
|
| 76703 |
MMAB
|
|
decreases_quantity of
|
Vitamin B12
|
via adenosylation of vitamin B12
|
| 76704 |
Methylcobalamin
|
|
increases_activity of
|
MTR
|
|
| 76789 |
Cobamide coenzyme
|
|
increases_activity of
|
MMUT
|
|
| 77143 |
LMBRD1
|
|
is localized in
|
lysosome
|
|
|
28572511
|
Metabolic
Methylmalonic aciduria
|
|
7,679
|
| 76907 |
LMBRD1
|
|
affects_activity of
|
Methylmalonic aciduria and homocystinuria, cblF type
|
|
| 76911 |
LMBRD1
|
|
increases_transport of
|
Vitamin B12
|
from the lysosome into the cytosol
|
|
19136951
|
Methylmalonic aciduria
Vitamin B12 deficiency
|
|
7,683
|
| 76927 |
MTR
|
|
increases_quantity of
|
Methionine
|
Methylcobalamin is required as cofactor
|
| 76931 |
MTR
|
|
decreases_quantity of
|
Homocysteine
|
Methylcobalamin is required as cofactor
|
| 76932 |
Methionine
|
|
increases_quantity of
|
S-Adenosylmethionine
|
|
| 76933 |
Homocysteine
|
|
increases_quantity of
|
Methionine
|
Methylcobalamin is required as cofactor
|
| 76934 |
MAT1A
|
|
increases_quantity of
|
S-Adenosylmethionine
|
|
| 76935 |
MAT1A
|
|
decreases_quantity of
|
Methionine
|
|
| 76939 |
LMBRD1
|
|
interacts (colocalizes) with
|
MMACHC
|
|
| 76940 |
MMADHC
|
|
affects_activity of
|
Methylmalonic aciduria and homocystinuria, cblD type
|
|
| 76941 |
MMACHC
|
|
interacts (colocalizes) with
|
MMADHC
|
|
| 76944 |
MMAB
|
|
affects_activity of
|
Methylmalonic aciduria, cblB type
|
|
| 76945 |
MMAA
|
|
affects_activity of
|
Methylmalonic aciduria, cblA type
|
|
| 76946 |
MMAA
|
|
interacts (colocalizes) with
|
MMUT
|
in mitochondria; to mediate the transfer of adenosylcobalamin from MMAB to MUT
|
| 76947 |
MMAA
|
|
interacts (colocalizes) with
|
MMAB
|
in mitochondria; to mediate the transfer of adenosylcobalamin from MMAB to MUT
|
| 76948 |
MTR
|
|
interacts (colocalizes) with
|
MMACHC
|
|
| 77183 |
MTR
|
|
is localized in
|
cytoplasm
|
|
| 77192 |
MMAA
|
|
is localized in
|
mitochondrion
|
|
| 77193 |
MMAB
|
|
is localized in
|
mitochondrion
|
|
| 77245 |
MTR
|
|
decreases_quantity of
|
5-Methyltetrahydrofolate
|
Methylcobalamin is required as cofactor
|
| 77246 |
5-Methyltetrahydrofolate
|
|
increases_quantity of
|
Methionine
|
Methylcobalamin is required as cofactor
|
|
27771510
|
Metabolic
Methylmalonic aciduria
Vitamin B12 deficiency
|
|
7,689
|
| 76949 |
MTR
|
|
interacts (colocalizes) with
|
MMADHC
|
in HepG2 cells and fibroblasts
|
| 76951 |
MTRR
|
|
interacts (colocalizes) with
|
MMACHC
|
HepG2 cells and fibroblasts
|
| 77010 |
MTR
|
|
interacts (colocalizes) with
|
MTRR
|
|
| 77011 |
MTR
|
|
interacts (colocalizes) with
|
MMACHC
|
|
| 77012 |
MMACHC
|
|
interacts (colocalizes) with
|
MMADHC
|
|
|
|
Metabolic
Vitamin B12 deficiency
|
|
7,693
|
| 77013 |
MMACHC
|
|
affects_activity of
|
Methylmalonic aciduria and homocystinuria, cblC type
|
|
| 77014 |
MMADHC
|
|
affects_activity of
|
Methylmalonic aciduria and homocystinuria, cblD type
|
|
| 77015 |
MMACHC
|
|
is localized in
|
cytoplasm
|
|
| 77016 |
MMADHC
|
|
is localized in
|
cytoplasm
|
|
| 77017 |
MMADHC
|
|
is localized in
|
mitochondrion
|
|
|
23270877
|
Methylmalonic aciduria
|
|
7,703
|
| 77067 |
LMBRD1
|
|
interacts (colocalizes) with
|
ABCD4
|
at the ER membrane; this induces the transport of ABCD4 to the lysosomes
|
| 77070 |
LMBRD1
|
|
increases_transport of
|
ABCD4
|
to the lysosomes
|
| 77075 |
ABCD4
|
|
is localized in
|
lysosome
|
only in the presence of LMBRD1
|
|
27456980
|
Metabolic
Methylmalonic aciduria
|
|
7,718
|
| 77159 |
MMACHC
|
|
affects_activity of
|
Methylmalonic aciduria and homocystinuria, cblC type
|
|
| 77168 |
MMACHC
|
|
interacts (colocalizes) with
|
MMADHC
|
if Cbl is bound to MMACHC
|
| 77169 |
MMACHC
|
|
interacts (colocalizes) with
|
Vitamin B12
|
|
|
26483544
|
Methylmalonic aciduria
|
|
7,730
|
| 77237 |
MTR
|
|
affects_activity of
|
Homocystinuria-megaloblastic anemia, cblG type
|
|
| 77238 |
MTRR
|
|
affects_activity of
|
Homocystinuria-megaloblastic anemia, cblE type
|
|
| 77239 |
MTR
|
|
increases_quantity of
|
Methionine
|
|
| 77242 |
MTR
|
|
decreases_quantity of
|
Homocysteine
|
|
| 77243 |
MTRR
|
|
increases_activity of
|
MTR
|
|
|
25526710
|
Vitamin B12 deficiency
|
|
7,732
|
| 77248 |
MMACHC
|
|
increases_quantity of
|
Cobamide coenzyme
|
|
| 77249 |
MMACHC
|
|
increases_quantity of
|
Methylcobalamin
|
|
| 77251 |
MTR
|
|
increases_quantity of
|
Methylcobalamin
|
|
|
23539619
|
Methylmalonic aciduria
Vitamin B12 deficiency
|
|
8,051
|
| 79694 |
Methylmalonate
|
|
increases_quantity of
|
Reactive oxygen species
|
in cortex, hippocampus and striatum
|
| 79695 |
Methylmalonate
|
|
increases_quantity of
|
TNF
|
in cortex, hippocampus and striatum
|
| 79697 |
Methylmalonate
|
|
increases_quantity of
|
CASP1
|
in cortex, hippocampus and striatum
|
| 79698 |
Methylmalonate
|
|
increases_quantity of
|
CASP3
|
in cortex, hippocampus and striatum
|
| 79699 |
Methylmalonate
|
|
increases_quantity of
|
CASP8
|
in cortex, hippocampus and striatum
|
| 79700 |
Methylmalonate
|
|
increases_activity of
|
microglial cell activation
|
in cortex, hippocampus and striatum
|
| 79701 |
Methylmalonate
|
|
increases_activity of
|
astrocyte activation
|
in cortex, hippocampus and striatum
|
| 79702 |
Methylmalonate
|
|
increases_activity of
|
memory
|
|
|
28395089
|
Methylmalonic aciduria
|
CIDeRplus