|
564
|
| 68999 |
UBE2N
|
|
is_part_of
|
Ubiquitin-conjugating enzyme E2 (UBC13-UEV1A)
|
|
| 69002 |
UBE2V1
|
|
is_part_of
|
Ubiquitin-conjugating enzyme E2 (UBC13-UEV1A)
|
|
| 69004 |
TRAF6
|
|
increases_activity of
|
Ubiquitin-conjugating enzyme E2 (UBC13-UEV1A)
|
|
| 69014 |
Ubiquitin-conjugating enzyme E2 (UBC13-UEV1A)
|
|
increases_activity of
|
I-kappa-B kinase complex
|
|
| 69020 |
Ubiquitin-conjugating enzyme E2 (UBC13-UEV1A)
|
|
increases_ubiquitination/sumoylation of
|
I-kappa-B kinase complex
|
|
|
11057907
|
Neurological
|
|
1,086
|
| 6893 |
NOS2
|
|
increases_quantity of
|
NO
|
|
|
19276172
|
Parkinson disease
|
|
1,092
|
| 7085 |
TNFRSF1A
|
|
increases_activity of
|
IKBKB
|
|
|
18053812
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
4,699
|
| 46639 |
NOS2
|
|
decreases_quantity of
|
Arginine
|
after induction with cytokines
|
|
7510950
|
Metabolic
Cardiovascular disease
|
|
5,237
|
| 50997 |
NFKBIA
|
|
decreases_activity of
|
NF-kappaB complex
|
|
|
15194459
|
Metabolic
Cardiovascular disease
|
|
6,641
|
| 63625 |
MAPK8
|
|
increases_activity of
|
JNK cascade
|
|
|
10582587
|
Neurological
|
|
6,819
|
| 66324 |
NFKB1
|
|
is_part_of
|
NF-kappaB complex
|
|
|
23709157
|
Inflammatory bowel disease 1
Inflammatory bowel disease
|
|
6,950
|
| 67922 |
NOD2
|
|
affects_activity of
|
Inflammasome
|
|
|
24740681
|
Inflammatory bowel disease 1
Inflammatory bowel disease
|
|
6,972
|
| 68383 |
NOD2
|
|
interacts (colocalizes) with
|
RIPK2
|
if NOD2 has been activated by N-acetyl muramyl dipeptide (MDP), a component of bacterial peptidoglycan.
|
| 68384 |
NOD2-RIPK2
|
|
increases_activity of
|
TRAF6
|
|
| 68385 |
TRAF6
|
|
increases_activity of
|
IKBKG
|
via ubiquitination
|
| 68386 |
TRAF6
|
|
increases_ubiquitination/sumoylation of
|
IKBKG
|
|
| 68388 |
NOD2
|
|
is_part_of
|
NOD2-RIPK2
|
|
| 68406 |
RIPK2
|
|
is_part_of
|
NOD2-RIPK2
|
|
| 68438 |
IKBKG
|
|
is_part_of
|
I-kappa-B kinase complex
|
via ubiquitination
|
| 68439 |
IKBKB
|
|
is_part_of
|
I-kappa-B kinase complex
|
via ubiquitination
|
| 68440 |
CHUK
|
|
is_part_of
|
I-kappa-B kinase complex
|
|
| 68441 |
I-kappa-B kinase complex
|
|
increases_phosphorylation of
|
NFKBIA
|
resulting in dissociation of NFKBIA from the NF-kappaB complex and subsequent activation of the complex
|
| 68442 |
I-kappa-B kinase complex
|
|
decreases_activity of
|
NFKBIA
|
|
| 68443 |
NFKBIA
|
|
decreases_activity of
|
NF-kappaB complex
|
via binding to the NF-kappaB complex
|
| 68919 |
Peptidoglycan
|
|
increases_activity of
|
NOD2
|
|
| 69049 |
NFKBIA
|
|
interacts (colocalizes) with
|
NF-kappaB complex
|
keeping the complex in an inactive state.
|
|
21252204
|
Inflammatory bowel disease
|
|
6,973
|
| 68390 |
NFKB2
|
|
is_part_of
|
NF-kappaB complex
|
|
| 68393 |
REL
|
|
is_part_of
|
NF-kappaB complex
|
|
|
22921465
|
Colorectal cancer
Inflammatory bowel disease
|
|
6,983
|
| 68512 |
TNFRSF1A
|
|
increases_activity of
|
apoptotic process
|
|
|
17361131
|
Inflammatory bowel disease
Inflammation
|
|
6,984
|
| 68520 |
REL
|
|
is_part_of
|
NF-kappaB complex
|
|
| 68521 |
RELA
|
|
is_part_of
|
NF-kappaB complex
|
|
| 68522 |
NFKB2
|
|
is_part_of
|
NF-kappaB complex
|
|
| 68523 |
NFKB1
|
|
is_part_of
|
NF-kappaB complex
|
|
| 68524 |
RELB
|
|
is_part_of
|
NF-kappaB complex
|
|
| 68526 |
RELA
|
|
increases_expression of
|
NOS2
|
|
|
15753535
|
Inflammatory bowel disease
|
|
6,986
|
| 68528 |
Inflammatory bowel disease
|
|
decreases_quantity of
|
Arginine
|
in colonic tissue
|
| 68531 |
Inflammatory bowel disease
|
|
increases_quantity of
|
Citrulline
|
in colonic tissue
|
| 68535 |
SLC7A2
|
|
increases_transport of
|
Arginine
|
into cells
|
| 68537 |
Inflammatory bowel disease
|
|
decreases_expression of
|
SLC7A2
|
in colonic tissue
|
| 68541 |
Inflammatory bowel disease
|
|
increases_expression of
|
NOS2
|
in colonic tissue
|
|
27104830
|
Inflammatory bowel disease
|
|
6,988
|
| 68553 |
Inflammatory bowel disease
|
|
increases_quantity of
|
NO
|
|
|
24430113
|
Inflammatory bowel disease
|
|
7,013
|
| 68676 |
TRAF6
|
|
interacts (colocalizes) with
|
IRAK1
|
|
| 68677 |
IRAK1
|
|
interacts (colocalizes) with
|
IL1R1
|
|
|
|
Inflammation
|
|
7,014
|
| 68694 |
IRAK1
|
|
increases_activity of
|
T-helper 17 cell differentiation
|
upon IL-1beta stimulation
|
| 69395 |
MYD88
|
|
interacts (colocalizes) with
|
IRAK4
|
after IL1 stimulation
|
| 69396 |
IRAK4
|
|
interacts (colocalizes) with
|
IRAK1
|
after IL1 stimulation
|
| 69397 |
IL1R1
|
|
increases_activity of
|
MYD88
|
after IL1 stimulation
|
| 69400 |
IL1B
|
|
interacts (colocalizes) with
|
IL1R1
|
in response to IL1beta
|
| 69401 |
IRAK1
|
|
increases_activity of
|
STAT3
|
in response to IL1beta via phosphorylation
|
| 69402 |
IRAK1
|
|
increases_phosphorylation of
|
STAT3
|
in response to IL1beta
|
| 69403 |
STAT3
|
|
increases_expression of
|
IL23R
|
in response to IL1beta
|
|
26561545
|
Inflammation
|
|
7,019
|
| 68737 |
TRAF3
|
|
interacts (colocalizes) with
|
TRAF3IP2
|
thus preventing TRAF3IP2 to bind with IL-17R
|
| 68780 |
TRAF3
|
|
decreases_activity of
|
TRAF3IP2
|
|
| 68846 |
RELA
|
|
is_part_of
|
NF-kappaB complex
|
|
| 68848 |
mir-30a
|
|
decreases_phosphorylation of
|
MAPK8
|
via downregulation of TRAF3IP2 expression
|
| 68851 |
mir-30a
|
|
decreases_expression of
|
TRAF3IP2
|
|
|
26376209
|
Inflammation
|
|
7,023
|
| 68746 |
IL17A
|
|
interacts (colocalizes) with
|
IL17RA-IL17RC
|
|
| 68750 |
IL17RA
|
|
is_part_of
|
IL17RA-IL17RC
|
|
| 68751 |
IL17RC
|
|
is_part_of
|
IL17RA-IL17RC
|
|
| 68753 |
IL17RA-IL17RC
|
|
interacts (colocalizes) with
|
TRAF3IP2
|
after induction by the ligand IL17
|
| 68769 |
TRAF3IP2
|
|
interacts (colocalizes) with
|
TRAF6
|
|
| 68770 |
TRAF3IP2
|
|
increases_ubiquitination/sumoylation of
|
TRAF6
|
|
| 68772 |
MAP3K7
|
|
is_part_of
|
TAK1 complex
|
|
| 68773 |
TAB2
|
|
is_part_of
|
TAK1 complex
|
|
| 68774 |
TAB3
|
|
is_part_of
|
TAK1 complex
|
|
| 68775 |
TAK1 complex
|
|
increases_activity of
|
I-kappa-B kinase complex
|
|
|
23557798
|
Inflammation
|
|
7,036
|
| 68858 |
CASP10
|
|
interacts (colocalizes) with
|
TNFRSF1A
|
|
|
9045686
|
Inflammation
|
|
7,037
|
| 68874 |
CIITA
|
|
decreases_activity of
|
NF-kappaB complex
|
|
|
26792751
|
Inflammation
|
|
7,039
|
| 68885 |
TRIM22
|
|
interacts (colocalizes) with
|
NOD2
|
in HT29 cells (human intestinal epithelial cell line)
|
| 68892 |
TRIM22
|
|
increases_ubiquitination/sumoylation of
|
NOD2
|
in HEK293 cells
|
|
26836588
|
Inflammation
|
|
7,043
|
| 69127 |
CYLD
|
|
decreases_activity of
|
TAK1 complex
|
via deubiquitination
|
|
|
Inflammation
|
|
7,044
|
| 68997 |
MALT1
|
|
interacts (colocalizes) with
|
BCL10
|
to activate NF-kappaB
|
| 69046 |
I-kappa-B kinase complex
|
|
increases_phosphorylation of
|
NFKBIA
|
in Jurkat cells; after induction with BCL10
|
| 69077 |
MALT1
|
|
increases_activity of
|
TRAF6
|
in Jurkat cells
|
| 69080 |
MALT1
|
|
interacts (colocalizes) with
|
TRAF6
|
in Jurkat cells
|
| 69083 |
MALT1
|
|
interacts (colocalizes) with
|
TRAF2
|
in Jurkat cells
|
| 69089 |
TRAF6
|
|
increases_ubiquitination/sumoylation of
|
IKBKG
|
in Jurkat cells; in the presence of the ubiquitin-conjugating enzyme (E2) complex UBC13-UEV1A
|
| 69113 |
IKBKG
|
|
increases_activity of
|
TAK1 complex
|
|
| 69118 |
TAK1 complex
|
|
increases_phosphorylation of
|
IKBKB
|
in Jurkat cells
|
| 69119 |
TAK1 complex
|
|
increases_activity of
|
I-kappa-B kinase complex
|
in Jurkat cells; via phosphorylation of IKKbeta
|
|
|
Inflammation
|
|
7,048
|
| 69129 |
XIAP
|
|
interacts (colocalizes) with
|
RIPK2
|
in HEK293T cells and THP-1 monocytes
|
|
|
Inflammation
|
|
7,049
|
| 69130 |
SHARPIN
|
|
is_part_of
|
LUBAC complex
|
|
| 69131 |
RBCK1
|
|
is_part_of
|
LUBAC complex
|
|
| 69132 |
RNF31
|
|
is_part_of
|
LUBAC complex
|
|
| 69189 |
XIAP
|
|
interacts (colocalizes) with
|
RIPK2
|
|
| 69191 |
XIAP
|
|
increases_ubiquitination/sumoylation of
|
RIPK2
|
in THP-1 cells
|
| 69193 |
BIRC2
|
|
increases_ubiquitination/sumoylation of
|
RIPK2
|
in HCT-116 cells ; together with BIRC3 and XIAP
|
| 69194 |
BIRC3
|
|
increases_ubiquitination/sumoylation of
|
RIPK2
|
in HCT-116 cells ; together with BIRC2 and XIAP
|
| 69296 |
LUBAC complex
|
|
increases_activity of
|
I-kappa-B kinase complex
|
in HCT-116 cells
|
| 69312 |
RIPK2
|
|
increases_activity of
|
LUBAC complex
|
in HCT-116 cells
|
| 69357 |
LUBAC complex
|
|
increases_ubiquitination/sumoylation of
|
I-kappa-B kinase complex
|
in HCT-116 cells
|
|
|
Inflammatory bowel disease
Inflammation
|
|
7,050
|
| 69156 |
CD40
|
|
interacts (colocalizes) with
|
TRAF3IP2
|
in HeLa and HT29 cells
|
|
|
Inflammation
|
|
7,051
|
| 69162 |
CD40LG
|
|
interacts (colocalizes) with
|
CD40
|
|
|
|
Inflammation
|
|
7,052
|
| 69337 |
TAK1 complex
|
|
increases_activity of
|
MAP2K6
|
if TAK1 complex has been ubiquitinylated by TRAF6 and Ubc13-Uev1A
|
| 69338 |
TAK1 complex
|
|
increases_phosphorylation of
|
MAP2K6
|
if TAK1 complex has been ubiquitinylated by TRAF6 and Ubc13-Uev1A
|
| 69340 |
MAP2K6
|
|
increases_activity of
|
MAPK8
|
if MKK6 has been ubiquitinylated by TRAF6 and Ubc13-Uev1A
|
|
|
Inflammation
|
|
7,053
|
| 69406 |
TNF
|
|
interacts (colocalizes) with
|
TNFRSF1A
|
|
| 69410 |
TNFRSF1B
|
|
affects_activity of
|
TNFRSF1A
|
by mediating the binding of TNF to TNFRSF1A
|
|
|
Inflammatory bowel disease
|
|
7,055
|
| 69422 |
SIVA1
|
|
increases_activity of
|
apoptotic process
|
in T cells
|
| 69433 |
SIVA1
|
|
interacts (colocalizes) with
|
XIAP
|
in HeLa cells and in Jurkat T cells
|
| 69527 |
SIVA1
|
|
increases_activity of
|
MAPK8
|
in HEK293 cells and in Jurkat T cells
|
| 69532 |
XIAP
|
|
increases_ubiquitination/sumoylation of
|
SIVA1
|
in Jurkat T cells
|
| 69533 |
XIAP
|
|
decreases_activity of
|
SIVA1
|
in Jurkat T cells ; via K48-linked ubiquitylation
|
| 69553 |
SIVA1
|
|
interacts (colocalizes) with
|
MAP3K7
|
in HEK293 cells
|
|
|
Metabolic
|
CIDeRplus