|
1,718
|
| 12900 |
PDX1
|
|
increases_expression of
|
INS
|
|
|
18252719
|
Neurological
|
|
2,938
|
| 26834 |
PDX1 rs193929377
|
|
increases_activity of
|
MODY, type IV
|
|
|
|
Diabetes mellitus, type II
Insulin resistance
MODY, type IV
|
|
2,966
|
| 27021 |
PDX1
|
|
affects_activity of
|
Diabetes mellitus, type II
|
in response to high-fat diet
|
| 27023 |
PDX1
|
|
affects_activity of
|
type B pancreatic cell proliferation
|
|
|
19855005
|
Diabetes mellitus, type II
Insulin resistance
MODY, type IV
|
|
2,971
|
| 27052 |
PDX1
|
|
affects_activity of
|
endocrine pancreas development
|
|
|
19487809
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,973
|
| 27089 |
PDX1
|
|
increases_activity of
|
insulin secretion involved in cellular response to glucose stimulus
|
|
|
19656489
|
Diabetes mellitus, type II
Insulin resistance
MODY, type IV
|
|
5,738
|
| 54273 |
PDX1 rs193929377
|
|
increases_activity of
|
increased circulating insulin level
|
|
| 54276 |
PDX1 rs193929377
|
|
increases_activity of
|
Obesity
|
|
| 132500 |
PDX1 rs193929377
|
|
increases_activity of
|
MODY, type IV
|
|
| 132502 |
PDX1
|
|
affects_activity of
|
Pancreatic agenesis 1
|
|
|
20621032
|
Diabetes mellitus, type II
Insulin resistance
MODY, type IV
|
|
5,741
|
| 54363 |
PDX1 rs193929377
|
|
decreases_activity of
|
pancreas development
|
|
|
8988180
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,742
|
| 54278 |
PDX1 rs193929377
|
|
increases_activity of
|
abnormal pancreatic beta cell physiology
|
in pancreas, in pancreatic islets
|
| 54385 |
PDX1 rs193929377
|
|
decreases_activity of
|
insulin secretion involved in cellular response to glucose stimulus
|
in pancreas, in pancreatic beta cells
|
|
11078452
|
Diabetes mellitus, type II
Insulin resistance
MODY, type IV
|
|
5,744
|
| 54280 |
PDX1 rs193929377
|
|
increases_activity of
|
Diabetes mellitus, permanent neonatal
|
in a homozygous mutation carrier
|
|
19496967
|
Diabetes mellitus, type II
Diabetes mellitus, permanent neonatal
Insulin resistance
|
|
5,770
|
| 54424 |
PDX1 rs137852787
|
|
increases_activity of
|
MODY, type IV
|
in Indo-Trinidadians
|
| 54504 |
PDX1 rs137852787
|
|
decreases_activity of
|
PDX1
|
|
|
14764823
|
Diabetes mellitus, type II
Insulin resistance
MODY, type IV
|
|
5,794
|
| 54666 |
PDX1
|
|
increases_expression of
|
SLC2A2
|
|
| 54669 |
PDX1
|
|
increases_activity of
|
insulin secretion involved in cellular response to glucose stimulus
|
|
|
11781323
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,795
|
| 54682 |
PDX1
|
|
increases_expression of
|
GCK
|
in mature pancreas
|
|
17659992
|
Diabetes mellitus, type II
Insulin resistance
|
|
7,531
|
| 74963 |
PDX1
|
|
decreases_expression of
|
GCG
|
in pancreatic beta cells; via binding to the G1 element
|
| 75141 |
PDX1
|
|
increases_expression of
|
INS
|
|
|
28275047
|
Diabetes mellitus, type II
Insulin resistance
|
|
13,888
|
| 131130 |
PDX1
|
|
affects_activity of
|
MODY, type IV
|
|
|
33292863
|
MODY
|
|
13,933
|
| 131647 |
PDX1-p.P63Rfs
|
|
increases_activity of
|
MODY, type IV
|
|
| 131648 |
PDX1 rs368507502
|
|
increases_activity of
|
MODY, type IV
|
|
|
31595705
|
MODY
|
|
13,966
|
| 131975 |
PDX1-p.V177M
|
|
increases_activity of
|
MODY, type IV
|
|
|
25041077
|
MODY
|
|
14,029
|
| 132503 |
PDX1-p.P63Rfs
|
|
increases_activity of
|
MODY, type IV
|
|
| 132504 |
PDX1-p.P63Rfs
|
|
increases_activity of
|
absent dorsal pancreas
|
|
|
28436541
|
MODY, type IV
|
CIDeRplus