|
6,474
|
| 61449 |
TGFB1
|
|
increases_activity of
|
epithelial to mesenchymal transition
|
in human lung epithelial cells (A549)
|
|
26415510
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,491
|
| 61600 |
Lithium
|
|
decreases_activity of
|
GSK3B
|
|
| 61607 |
GSK3B
|
|
increases_phosphorylation of
|
KCNQ2
|
|
| 61608 |
GSK3B
|
|
decreases_activity of
|
KCNQ2
|
|
| 63413 |
Lithium
|
|
increases_activity of
|
KCNQ2
|
via inhibiting GSK3beta activity
|
| 63754 |
KCNQ2
|
|
increases_activity of
|
ion transport
|
|
|
16733521
|
Bipolar disorder
Metabolic
|
|
6,492
|
| 61636 |
Lithium
|
|
decreases_activity of
|
INPP1
|
|
| 61638 |
Lithium
|
|
decreases_activity of
|
FBP
|
|
| 61639 |
Lithium
|
|
decreases_activity of
|
BPNT1
|
|
| 61640 |
Lithium
|
|
decreases_activity of
|
PGM
|
|
| 61659 |
Lithium
|
|
decreases_activity of
|
GSK3B
|
|
| 61663 |
INPP1
|
|
increases_quantity of
|
Inositol
|
|
| 61664 |
Inositol
|
|
increases_quantity of
|
Phosphatidylinositol-4,5-bisphosphate
|
|
| 61708 |
BPNT1
|
|
affects_quantity of
|
Inositol
|
|
| 61814 |
Lithium
|
|
decreases_activity of
|
SLC5A3
|
|
| 61815 |
Lithium
|
|
decreases_expression of
|
SLC5A3
|
|
| 61816 |
SLC5A3
|
|
increases_transport of
|
Inositol
|
|
| 61817 |
Inositol
|
|
increases_activity of
|
phosphatidylinositol-mediated signaling
|
|
| 61983 |
Diacylglycerol
|
|
increases_activity of
|
Protein kinase C
|
|
| 62202 |
Phosphatidylinositol-4,5-bisphosphate
|
|
increases_quantity of
|
Diacylglycerol
|
|
| 62203 |
Phosphatidylinositol-4,5-bisphosphate
|
|
increases_quantity of
|
Inositol 1,4,5-trisphosphate
|
|
| 62345 |
Diacylglycerol
|
|
increases_activity of
|
Protein kinase C
|
|
| 62346 |
Inositol 1,4,5-trisphosphate
|
|
increases_activity of
|
calcium-mediated signaling
|
|
| 62972 |
Lithium
|
|
affects_activity of
|
Adenylate cyclase
|
|
| 63702 |
FBP
|
|
increases_activity of
|
glucose metabolic process
|
|
| 63703 |
PGM
|
|
increases_activity of
|
glucose metabolic process
|
|
|
15471909
|
Metabolic
|
|
6,496
|
| 61697 |
Phosphatidylinositol-4,5-bisphosphate
|
|
interacts (colocalizes) with
|
KCNQ2
|
|
| 61704 |
Phosphatidylinositol-4,5-bisphosphate
|
|
increases_activity of
|
KCNQ2
|
|
|
24277843
|
Metabolic
|
|
6,505
|
| 61794 |
Lithium
|
|
increases_quantity of
|
IMPA1
|
|
|
12551726
|
Metabolic
|
|
6,508
|
| 61821 |
Lithium
|
|
decreases_quantity of
|
AQP2
|
in inner medulla membrane of kidney
|
|
7535800
|
Metabolic
|
|
6,510
|
| 61893 |
Lithium
|
|
increases_activity of
|
autophagy
|
|
| 61920 |
Lithium
|
|
decreases_quantity of
|
ARRB2
|
|
|
23759441
|
Metabolic
Ophtalmological
|
|
6,516
|
| 61954 |
Lithium
|
|
decreases_activity of
|
IMPA1
|
Sensitivity of IMPA2 to lithium is lower than sensitivity of IMPA1 to lithium.
|
| 61956 |
Lithium
|
|
decreases_activity of
|
IMPA2
|
Sensitivity of IMPA2 to lithium is lower than sensitivity of IMPA1 to lithium.
|
| 62086 |
IMPA1
|
|
increases_quantity of
|
Inositol
|
|
| 62087 |
IMPA2
|
|
increases_quantity of
|
Inositol
|
|
|
17068342
|
Metabolic
|
|
6,517
|
| 61967 |
Lithium
|
|
increases_activity of
|
autophagy
|
via inhibiting IMPase activity resulting in lower IP3 levels
|
| 62105 |
Inositol 1,4,5-trisphosphate
|
|
decreases_activity of
|
autophagy
|
|
|
16186256
|
Metabolic
|
|
6,530
|
| 62126 |
Lithium
|
|
decreases_activity of
|
GSK3B
|
in adipocytes
|
|
10364240
|
Metabolic
|
|
6,533
|
| 62141 |
Lithium
|
|
increases_activity of
|
GYS
|
in hepatocytes; in the absence of glucose
|
| 62144 |
Lithium
|
|
increases_activity of
|
PYGL
|
in hepatocytes
|
| 63696 |
GYS
|
|
increases_activity of
|
glucose metabolic process
|
in hepatocytes
|
| 63697 |
PYGL
|
|
affects_activity of
|
glucose metabolic process
|
in hepatocytes
|
|
|
Metabolic
|
|
6,545
|
| 62227 |
AP-1 complex
|
|
increases_expression of
|
TH
|
in frontal cortex, hippocampus, and striatum; After stimulation of AP-1 DNA-binding activity with lithium.
|
|
9523597
|
Neurological
|
|
6,547
|
| 62234 |
Lithium
|
|
increases_activity of
|
AP-1 complex
|
in a PKC-dependent manner
|
| 62237 |
MAPK8
|
|
increases_phosphorylation of
|
JUN
|
|
| 62238 |
Protein kinase C
|
|
increases_activity of
|
MAPK8
|
|
| 62240 |
JUN
|
|
is_part_of
|
AP-1 complex
|
|
| 63642 |
MAPK8
|
|
increases_activity of
|
JUN
|
|
|
10582587
|
Neurological
|
|
6,549
|
| 62258 |
GSK3B
|
|
decreases_activity of
|
JUN
|
|
| 62260 |
Lithium
|
|
increases_activity of
|
JUN
|
in embryos; via inhibition of GSK3beta, an inhibitor of c-Jun activity
|
|
9169052
|
Developmental
|
|
6,551
|
| 62269 |
BPNT1
|
|
increases_quantity of
|
AMP
|
|
| 62271 |
Lithium
|
|
decreases_activity of
|
BPNT1
|
|
|
10675562
|
Metabolic
|
|
6,552
|
| 62278 |
Lithium
|
|
decreases_activity of
|
BPNT1
|
|
|
10347153
|
Metabolic
|
|
6,558
|
| 62313 |
Lithium
|
|
decreases_activity of
|
GNAI1
|
by inhibiting the formation of the GDP.AlF.Gi(alpha)1 complex
|
|
11361143
|
Metabolic
|
|
6,564
|
| 62423 |
Lithium
|
|
decreases_activity of
|
PGM
|
by competing with magnesium, a cofactor of the enzyme
|
| 63695 |
PGM
|
|
increases_activity of
|
glucose metabolic process
|
|
|
11500487
|
Metabolic
|
|
6,565
|
| 62428 |
Lithium
|
|
decreases_quantity of
|
alpha-D-Glucose 1,6-bisphosphate
|
in diaphragm muscle, tibialis anterior muscle and brain, but there is no effect in liver
|
| 62430 |
alpha-D-Glucose 1,6-bisphosphate
|
|
increases_activity of
|
PFK
|
in diaphragm muscle, tibialis anterior muscle and brain, but there is no effect in liver
|
| 62432 |
Lithium
|
|
decreases_activity of
|
PFK
|
in diaphragm muscle, tibialis anterior muscle and brain, but there is no effect in liver
|
| 62434 |
alpha-D-Glucose 1,6-bisphosphate
|
|
increases_activity of
|
PGM
|
in diaphragm muscle, tibialis anterior muscle and brain, but there is no effect in liver
|
| 63693 |
PFK
|
|
increases_activity of
|
glucose metabolic process
|
in diaphragm muscle, tibialis anterior muscle and brain, but there is no effect in liver
|
|
|
Metabolic
|
|
6,566
|
| 62447 |
Lithium
|
|
decreases_activity of
|
PGM
|
in leukocytes
|
| 62471 |
Lithium
|
|
increases_expression of
|
PGM
|
in leukocytes; as a compensatory effect
|
|
16259646
|
Metabolic
|
|
6,567
|
| 62449 |
Lithium
|
|
decreases_activity of
|
PGM
|
in homogenates from cortex, hippocampus, striatum, brainstem and cerebellum
|
| 62491 |
Lithium
|
|
increases_phosphorylation of
|
GYS
|
|
|
20637832
|
Metabolic
|
|
6,568
|
| 62457 |
Lithium
|
|
decreases_activity of
|
FBP
|
in vitro
|
|
8608143
|
Metabolic
|
|
6,569
|
| 62458 |
GSK3B
|
|
decreases_activity of
|
GYS
|
in vitro
|
|
|
Metabolic
|
|
6,570
|
| 62540 |
Lithium
|
|
increases_phosphorylation of
|
GSK3B
|
in HEK293 cells; at Ser-9, via PI3 kinase-dependent activation of protein kinase C
|
| 62543 |
Protein kinase C
|
|
increases_phosphorylation of
|
GSK3B
|
in HEK293 cells; induced by lithium
|
| 62548 |
Phosphatidylinositol 3-kinase
|
|
increases_activity of
|
Protein kinase C
|
induced by lithium
|
| 62550 |
Lithium
|
|
increases_activity of
|
Phosphatidylinositol 3-kinase
|
followed by activation of PRKCA and aubsequent phosphorylation of GSK3beta at Ser-9.
|
|
15456937
|
Metabolic
|
|
6,571
|
| 62541 |
Lithium
|
|
increases_phosphorylation of
|
GSK3B
|
in PC-12 cells; at Ser-9
|
|
15456937
|
Metabolic
|
|
6,572
|
| 62542 |
Lithium
|
|
increases_phosphorylation of
|
GSK3B
|
in hippocampus; at Ser-9, a phosphorylation site known to inhibit GSK activity
|
| 62552 |
Lithium
|
|
increases_activity of
|
Protein kinase C
|
in hippocampus
|
|
15456937
|
Neurological
|
|
6,573
|
| 62555 |
Lithium
|
|
decreases_activity of
|
GSK3B
|
via competing for magnesium
|
| 62556 |
Lithium
|
|
decreases_activity of
|
GSK3A
|
via competing for magnesium
|
|
11162580
|
Metabolic
|
|
6,574
|
| 62557 |
Lithium
|
|
increases_activity of
|
Phosphatidylinositol 3-kinase
|
|
| 63545 |
Phosphatidylinositol 3-kinase
|
|
increases_activity of
|
AKT1
|
|
|
10411946
|
Neurological
|
|
6,575
|
| 62568 |
Protein kinase A
|
|
increases_phosphorylation of
|
CREB1
|
via AKT/GSK-3beta and cAMP/PKA signaling pathways.
|
| 62569 |
Protein kinase A
|
|
increases_activity of
|
CREB1
|
via AKT/GSK-3beta and cAMP/PKA signaling pathways.
|
| 62969 |
CREB1
|
|
increases_expression of
|
BDNF
|
|
| 62970 |
CREB1
|
|
increases_expression of
|
BCL2
|
|
|
18077182
|
Neurological
|
|
6,577
|
| 62574 |
Lithium
|
|
decreases_activity of
|
apoptotic process
|
if apoptosis has been induced by ceramide
|
|
11897496
|
Neurological
|
CIDeRplus