|
5,786
|
| 54599 |
LRP5
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
The amount of LRP5 is associated with disease progression and severity.
|
| 56108 |
LRP6
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 58365 |
LRP5
|
|
increases_activity of
|
canonical Wnt signaling pathway
|
|
| 58366 |
LRP6
|
|
increases_activity of
|
canonical Wnt signaling pathway
|
|
|
24921217
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,787
|
| 54625 |
LRP5
|
|
increases_quantity of
|
TGFB1
|
in alveolar type 2 cells and leukocytes
|
|
24921217
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,792
|
| 54632 |
TERT
|
|
increases_activity of
|
telomere maintenance
|
|
| 54636 |
TERC
|
|
increases_activity of
|
telomere maintenance
|
|
| 54638 |
SFTPA2
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 54639 |
SFTPC
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 54650 |
MUC5B
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 54651 |
MUC5B rs35705950
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
the risk allele is T.
The mutation exists in approximately 50‚Äď60% of individuals with FIP or IPF and is estimated to increase the disease risk for heterozygotes 6-fold and 20-fold for homozygotes.
|
| 57654 |
MUC5B rs35705950
|
|
increases_expression of
|
MUC5B
|
the risk allele is T.
|
|
24429156
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,816
|
| 54917 |
TGFB1
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
|
|
21642472
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,824
|
| 55006 |
cigarette smoking
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 55007 |
aerosol exposure
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
|
|
24424167
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,963
|
| 56112 |
ABCA3
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 56115 |
SFTPC
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
|
20656946
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,964
|
| 56117 |
SFTPA2
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 56121 |
SFTPA2
|
|
increases_activity of
|
response to host defenses
|
|
| 58347 |
SFTPA2
|
|
increases_activity of
|
surfactant homeostasis
|
|
|
19100526
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,965
|
| 56122 |
TERT
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
via maintaining telomere length
|
| 56124 |
TERC
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
via maintaining telomere length
|
| 56140 |
TERT
|
|
is_part_of
|
Telomerase RNP complex
|
|
| 56141 |
TERC
|
|
is_part_of
|
Telomerase RNP complex
|
telomerase RNA template component of the telomerase complex
|
| 56142 |
Telomerase RNP complex
|
|
increases_activity of
|
telomere maintenance
|
|
| 58350 |
telomere maintenance
|
|
decreases_activity of
|
abnormal telomere length
|
|
|
17392301
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,967
|
| 56145 |
DKC1
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 56154 |
abnormal telomere length
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 56156 |
DKC1
|
|
increases_quantity of
|
TERC
|
in lymphoblastoid cells
|
|
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,968
|
| 56159 |
TINF2
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 56162 |
TINF2
|
|
is_part_of
|
Shelterin complex
|
|
| 56163 |
Shelterin complex
|
|
increases_activity of
|
telomere maintenance
|
|
|
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,971
|
| 56212 |
RTEL1
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 56221 |
RTEL1
|
|
increases_activity of
|
telomere maintenance
|
via telomerase
|
|
25607374
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
5,977
|
| 56241 |
TERC
|
|
affects_quantity of
|
SFTPC
|
expressed in alveolar epithelial cells
|
|
18952756
|
Metabolic
Lung disease
|
|
6,011
|
| 56356 |
DKC1
|
|
affects_activity of
|
Pulmonary fibrosis, idiopathic
|
|
|
24072216
|
Pulmonary fibrosis, idiopathic
Dyskeratosis congenita, X-linked
Lung disease
|
|
6,013
|
| 56377 |
Pulmonary fibrosis, idiopathic
|
|
increases_expression of
|
MUC5B
|
|
|
23583980
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,023
|
| 58349 |
SFTPC
|
|
increases_activity of
|
surfactant homeostasis
|
|
|
23268535
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,027
|
| 56474 |
SFTPC
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
if C-terminal BRICHOS domain is mutated resulting in missfolded SFTPC propeptide within the ER leading to ER-stress and unfolded protein response
|
|
15778495
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,030
|
| 56493 |
Pulmonary fibrosis, idiopathic
|
|
increases_quantity of
|
ATF6
|
in alveolar epithelial cells, type II (AEC2)
|
| 56494 |
Pulmonary fibrosis, idiopathic
|
|
increases_quantity of
|
ATF4
|
in alveolar epithelial cells, type II (AEC2)
|
| 56496 |
Pulmonary fibrosis, idiopathic
|
|
increases_expression of
|
XBP1
|
in alveolar epithelial cells, type II (AEC2)
|
| 56497 |
ATF6
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
| 56498 |
ATF4
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
| 56500 |
XBP1
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
|
18635891
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,031
|
| 56508 |
SFTPA2
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
|
|
20466729
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,033
|
| 56530 |
TGFB1
|
|
increases_activity of
|
epithelial to mesenchymal transition
|
|
| 73193 |
transforming growth factor beta receptor signaling pathway
|
|
increases_activity of
|
epithelial to mesenchymal transition
|
|
|
21498628
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,036
|
| 56548 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
epithelial to mesenchymal transition
|
in alveolar epithelial cells, type II
|
|
21757695
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,068
|
| 56752 |
Pulmonary fibrosis, idiopathic
|
|
increases_activity of
|
canonical Wnt signaling pathway
|
|
| 56755 |
CCN4
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 56766 |
canonical Wnt signaling pathway
|
|
increases_expression of
|
CCN4
|
|
| 57124 |
CCN4
|
|
increases_activity of
|
Pulmonary fibrosis, idiopathic
|
|
| 58357 |
CCN4
|
|
increases_activity of
|
ECM deposition
|
|
|
19287097
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,109
|
| 58351 |
canonical Wnt signaling pathway
|
|
increases_expression of
|
TERT
|
|
|
22723415
|
Metabolic
Lung disease
|
|
6,112
|
| 57159 |
Pulmonary fibrosis, idiopathic
|
|
increases_quantity of
|
PSMD11
|
in myofibroblasts and hyperplastic alveolar epithelial cells overlying fibroblast foci of IPF patients
|
| 57179 |
Pulmonary fibrosis, idiopathic
|
|
increases_activity of
|
proteasome-mediated ubiquitin-dependent protein catabolic process
|
in myofibroblasts and hyperplastic alveolar epithelial cells overlying fibroblast foci of IPF patients
|
|
26207697
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,113
|
| 57171 |
PSMD11
|
|
increases_activity of
|
proteasome-mediated ubiquitin-dependent protein catabolic process
|
in lung fibroblasts (CCL206 cells)
|
|
26207697
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,114
|
| 57182 |
FOXO3
|
|
increases_activity of
|
autophagy
|
|
| 57183 |
Pulmonary fibrosis, idiopathic
|
|
decreases_expression of
|
FOXO3
|
in fibroblasts
|
|
26186945
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,115
|
| 57219 |
TGFB1
|
|
increases_expression of
|
SERPINE2
|
in pulmonary fibroblasts
|
| 57223 |
SERPINE2
|
|
decreases_activity of
|
Thrombin
|
in pulmonary fibroblasts
|
| 57230 |
SERPINE2
|
|
increases_expression of
|
FN1
|
in pulmonary fibroblasts
|
| 58344 |
FN1
|
|
increases_activity of
|
ECM deposition
|
in pulmonary fibroblasts
|
|
25199049
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,117
|
| 57240 |
Pulmonary fibrosis, idiopathic
|
|
increases_quantity of
|
NOX4
|
in fibroblastic foci
|
|
19701206
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,124
|
| 57263 |
Pulmonary fibrosis, idiopathic
|
|
increases_quantity of
|
NOX4
|
in fibroblasts
|
| 57264 |
Pulmonary fibrosis, idiopathic
|
|
decreases_quantity of
|
NFE2L2
|
in fibroblasts within fibroblastic foci
|
| 57266 |
NOX4
|
|
increases_quantity of
|
Reactive oxygen species
|
in fibroblasts
|
| 57267 |
NFE2L2
|
|
decreases_quantity of
|
Reactive oxygen species
|
in fibroblasts within fibroblastic foci
|
|
24718857
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,138
|
| 58358 |
mir-21
|
|
increases_activity of
|
ECM deposition
|
|
|
20643828
|
Lung disease
|
|
6,141
|
| 57467 |
Pulmonary fibrosis, idiopathic
|
|
increases_expression of
|
mir-21
|
in myofibroblasts
|
|
20643828
|
Pulmonary fibrosis, idiopathic
Lung disease
|
CIDeRplus