|
4,844
|
| 47774 |
IDO1
|
|
decreases_quantity of
|
Tryptophan
|
|
| 47776 |
IDO1
|
|
increases_quantity of
|
Kynurenine
|
|
| 47812 |
Tryptophan
|
|
increases_quantity of
|
Kynurenine
|
|
|
12814390
|
Cardiovascular disease
Coronary heart disease
|
|
7,493
|
| 73939 |
Tetrahydrobiopterin
|
|
decreases_activity of
|
GCH1
|
via feedback regulation
|
| 74081 |
GCH1
|
|
increases_quantity of
|
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine
|
|
| 74094 |
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine
|
|
increases_quantity of
|
6-Pyruvoyltetrahydropterin
|
via 6-pyruvoyltetrahydropterin synthase
|
| 74095 |
GCH1
|
|
decreases_quantity of
|
GTP
|
|
| 74123 |
GTP
|
|
increases_quantity of
|
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine
|
via GTP cyclohydrolase I (GCH1)
|
| 74127 |
PTS
|
|
increases_quantity of
|
6-Pyruvoyltetrahydropterin
|
|
| 74128 |
PTS
|
|
decreases_quantity of
|
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine
|
|
| 74130 |
SPR
|
|
increases_quantity of
|
Tetrahydrobiopterin
|
|
| 74132 |
SPR
|
|
decreases_quantity of
|
6-Pyruvoyltetrahydropterin
|
|
| 74133 |
6-Pyruvoyltetrahydropterin
|
|
increases_quantity of
|
Tetrahydrobiopterin
|
via Sepiapterin (SPR)
|
|
8702680
|
Metabolic
|
|
7,510
|
| 74096 |
Tetrahydrobiopterin
|
|
increases_activity of
|
PAH
|
|
| 74097 |
Tetrahydrobiopterin
|
|
increases_activity of
|
TH
|
|
| 74100 |
Tetrahydrobiopterin
|
|
increases_activity of
|
TPH1
|
|
| 74103 |
Tetrahydrobiopterin
|
|
decreases_activity of
|
GCH1
|
together with GCHFR (GFRP, p35)
|
|
8502995
|
Metabolic
|
|
7,514
|
| 74137 |
GCHFR
|
|
interacts (colocalizes) with
|
GCH1
|
activity is dependent on the presence of BH4
|
| 74153 |
GCHFR
|
|
decreases_activity of
|
GCH1
|
in the presence of BH4
|
| 74154 |
Phenylalanine
|
|
increases_activity of
|
GCH1
|
in the presence of BH4
|
|
8702680
|
Metabolic
|
|
7,536
|
| 74532 |
PAH
|
|
decreases_quantity of
|
Phenylalanine
|
|
| 74533 |
PAH
|
|
increases_quantity of
|
Tyrosine
|
|
| 74534 |
TH
|
|
decreases_quantity of
|
Tyrosine
|
|
| 74536 |
Phenylalanine
|
|
increases_quantity of
|
Tyrosine
|
|
| 74538 |
TPH1
|
|
decreases_quantity of
|
Tryptophan
|
|
| 74539 |
TPH1
|
|
increases_quantity of
|
5-Hydroxytryptophan
|
|
| 74540 |
Tryptophan
|
|
increases_quantity of
|
5-Hydroxytryptophan
|
|
| 74541 |
5-Hydroxytryptophan
|
|
increases_quantity of
|
Serotonin
|
|
|
26241318
|
Metabolic
|
|
7,537
|
| 74546 |
Phenylketonuria
|
|
increases_activity of
|
Hyperphenylalaninemia
|
|
| 76114 |
Hyperphenylalaninemia
|
|
increases_quantity of
|
Phenylalanine
|
|
| 76115 |
Phenylketonuria
|
|
decreases_activity of
|
PAH
|
|
|
23622399
|
Metabolic
Phenylketonuria
Methylmalonic aciduria
|
|
7,538
|
| 74600 |
Serotonin
|
|
increases_quantity of
|
Melatonin
|
|
|
27513937
|
Metabolic
Phenylketonuria
|
|
7,539
|
| 74557 |
SLC7A5
|
|
increases_transport of
|
Phenylalanine
|
into the brain; via the blood brain barrier
|
| 74587 |
SLC7A5
|
|
increases_transport of
|
Tyrosine
|
into the brain; via the blood brain barrier
|
| 74588 |
SLC7A5
|
|
increases_transport of
|
Tryptophan
|
into the brain; via the blood brain barrier
|
| 74862 |
Phenylalanine
|
|
affects_activity of
|
SLC7A5
|
if the concentration of Phe is high
|
|
19191004
|
Metabolic
Phenylketonuria
|
|
7,543
|
| 74648 |
DDC
|
|
increases_quantity of
|
Serotonin
|
|
| 74649 |
DDC
|
|
decreases_quantity of
|
5-Hydroxytryptophan
|
|
|
27251625
|
Neurological
Inflammation
|
|
7,548
|
| 74699 |
Phenylalanine
|
|
decreases_activity of
|
TH
|
|
| 74710 |
TH
|
|
increases_quantity of
|
3,4-Dihydroxy-L-phenylalanine
|
|
| 74711 |
TH
|
|
decreases_quantity of
|
Tyrosine
|
|
| 74712 |
DDC
|
|
decreases_quantity of
|
3,4-Dihydroxy-L-phenylalanine
|
|
| 74713 |
DDC
|
|
increases_quantity of
|
Dopamine
|
|
| 74714 |
3,4-Dihydroxy-L-phenylalanine
|
|
increases_quantity of
|
Dopamine
|
|
| 74715 |
Tyrosine
|
|
increases_quantity of
|
3,4-Dihydroxy-L-phenylalanine
|
|
|
|
Metabolic
|
|
7,552
|
| 74763 |
DBH
|
|
increases_quantity of
|
Noradrenaline
|
|
| 74764 |
DBH
|
|
decreases_quantity of
|
Dopamine
|
|
| 74765 |
Dopamine
|
|
increases_quantity of
|
Noradrenaline
|
|
|
27778639
|
Neurological
|
|
7,553
|
| 74779 |
Tyrosine
|
|
increases_quantity of
|
3,4-Dihydroxy-L-phenylalanine
|
|
| 74780 |
3,4-Dihydroxy-L-phenylalanine
|
|
increases_quantity of
|
Melanin
|
|
| 74841 |
PNMT
|
|
increases_quantity of
|
Adrenaline
|
|
| 74842 |
PNMT
|
|
decreases_quantity of
|
Noradrenaline
|
|
| 76106 |
Noradrenaline
|
|
increases_quantity of
|
Adrenaline
|
|
|
8204666
|
Metabolic
|
|
7,559
|
| 74812 |
Phenylalanine
|
|
increases_quantity of
|
Phenylpyruvate
|
by phenylalanine (histidine) transaminase
|
| 74821 |
Phenylalanine (histidine) transaminase
|
|
increases_quantity of
|
Phenylpyruvate
|
mainly in liver; and alanine
|
| 74825 |
Phenylalanine (histidine) transaminase
|
|
decreases_quantity of
|
Phenylalanine
|
mainly in liver; by using pyruvate as cofactor
|
| 74850 |
Phenylpyruvate
|
|
increases_quantity of
|
Phenyllactate
|
|
| 74851 |
Phenylpyruvate
|
|
increases_quantity of
|
Phenylacetic acid
|
|
| 74891 |
Phenylpyruvate
|
|
decreases_activity of
|
HMGCR
|
|
| 74892 |
Phenylacetic acid
|
|
decreases_activity of
|
HMGCR
|
|
|
26425393
|
Metabolic
Phenylketonuria
|
|
7,563
|
| 74885 |
HMGCR
|
|
increases_quantity of
|
Cholesterol
|
|
|
10956425
|
Metabolic
Phenylketonuria
|
|
7,608
|
| 76058 |
alpha-Tocopherolquinone
|
|
increases_quantity of
|
Arachidonic acid
|
|
| 76060 |
alpha-Tocopherolquinone
|
|
increases_quantity of
|
Docosahexaenoic acid
|
|
| 76062 |
alpha-Tocopherol
|
|
increases_quantity of
|
alpha-Tocopherolquinone
|
|
| 76063 |
Phenylpyruvate
|
|
decreases_quantity of
|
alpha-Tocopherol
|
by inhibiting 4-hydroxyphenylpyruvate dioxygenase
|
| 76064 |
Phenyllactate
|
|
decreases_quantity of
|
alpha-Tocopherol
|
by inhibiting 4-hydroxyphenylpyruvate dioxygenase
|
|
11243724
|
Metabolic
Phenylketonuria
|
CIDeRplus