General Information:

Id: 9,161 (click here to show other Interactions for entry)
Diseases: Major depressive disorder - [OMIM]
Neurological
Homo sapiens
306 MDD patients treated with citalopram or escitalopram
article/cited
Reference: Gupta M et al.(2016) TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics Mol. Psychiatry 21: 1717-1725 [PMID: 26903268]

Interaction Information:

Comment When TSPAN5 was knocked down more than 70% in SK-N-BE(2) cells, there was a significant decrease of mRNA and protein levels for the serotonin pathway enzymes TPH1, TPH2, DDC, MAOA, as well as the serotonin transporter SLC6A4.
Formal Description
Interaction-ID: 136240

phenotype

decreased TSPAN5 level

decreases_quantity of

gene/protein

TPH2

in SK-N-BE(2) cells; when TSPAN5 was knocked down; concerning mRNA and protein levels for the serotonin pathway enzymes TPH1, TPH2, DDC, MAOA