CIDeRplusGeneral Information:
| Id: | 8,191 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Nephropathy, diabetic |
| Mammalia | |
| review | |
| Reference: | Vukovic I et al.(2015) The missing link - likely pathogenetic role of GM3 and other gangliosides in the development of diabetic nephropathy Kidney Blood Press. Res. 40: 306-314 [PMID: 26043887] |
Interaction Information:
| Comment | The AT1 receptor is a G protein-coupled receptor. Commonly, Gq alpha subunit of G protein-coupled receptors activates phospholipase C. Phospholipase C generates DAG as second messenger of AT1 receptor binding, further activating protein kinase C. PKC induction by AT1 is synergistically affected by reactive oxygen species, generated by interactions of AGE and corresponding receptors, which also increases the phospholipase C activity producing more molecular units of DAG. This double pathway PKC activation defines its central role in diabetic nephropathy pathogenesis. |
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Formal Description Interaction-ID: 82511 |
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| Drugbank entries | Show/Hide entries for PLC |