CIDeRplusGeneral Information:
| Id: | 7,608 (click here to show other Interactions for entry) |
| Diseases: |
Metabolic
Phenylketonuria - [OMIM] |
| Mammalia | |
| review | |
| Reference: | Infante JP and Huszagh VA(2001) Impaired arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria Mol. Genet. Metab. 72: 185-198 [PMID: 11243724] |
Interaction Information:
| Comment | Arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) are synthesized by carnitine-dependent mitochondrial fatty acid desaturases for which alpha-tocopherolquinone is an essential enzyme cofactor. Alpha-tocopherolquinone can be synthesized either de novo or from alpha-tocopherol. The fetus or newborn primarily relies on de novo alpha-TQ synthesis for these mitochondrial fatty acid desaturases because of low maternal transfer of alpha-tocopherol. |
|
Formal Description Interaction-ID: 76060 |
drug/chemical compound alpha-Tocopherolquinone increases_quantity of drug/chemical compound |