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Field	Query

	Field	Term

General Information:

Id:	7,164
Diseases:	COACH syndrome Ciliopathy Joubert syndrome 6 - [OMIM] Meckel syndrome, type 3 - [OMIM] Nephronophthisis 11 - [OMIM]
Organism:	Mus musculus
Publication type:	article
Reference:	[PMID: 26035863]

Interaction Information:

Comment	TMEM67 (meckelin) is essential for phosphorylation of the non-canonical Wnt receptor ROR2 (receptor-tyrosine-kinase-like orphan receptor 2) upon stimulation with Wnt5a-conditioned medium. ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone.
Formal Description Interaction-ID: 70409	gene/protein TMEM67 increases_phosphorylation of gene/protein ROR2

Comment	TMEM67 (meckelin) is essential for phosphorylation of the non-canonical Wnt receptor ROR2 (receptor-tyrosine-kinase-like orphan receptor 2) upon stimulation with Wnt5a-conditioned medium. ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone.
Formal Description Interaction-ID: 70525	gene/protein TMEM67 interacts (colocalizes) with gene/protein ROR2 at the ciliary transition zone

Comment	The extracellular N-terminal domain of TMEM67 preferentially binds to Wnt5a in an in vitro binding assay.
Formal Description Interaction-ID: 70526	gene/protein TMEM67 interacts (colocalizes) with gene/protein WNT5A

Comment	Wnt5a inhibited both the Shh and canonical Wnt/beta-catenin signalling pathways in wild-type embryonic lung.
Formal Description Interaction-ID: 70527	gene/protein WNT5A decreases_activity of process smoothened signaling pathway in embryonic lung

Comment	Wnt5a inhibited both the Shh and canonical Wnt/beta-catenin signalling pathways in wild-type embryonic lung.
Formal Description Interaction-ID: 70528	gene/protein WNT5A decreases_activity of process canonical Wnt signaling pathway in embryonic lung

Comment	TMEM67 is a receptor that has a main role in non-canonical Wnt signalling, mediated by Wnt5a and ROR2, and normally represses Shh signalling.
Formal Description Interaction-ID: 70529	gene/protein TMEM67 increases_activity of process non-canonical Wnt signaling pathway

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