General Information:

Id: 5,454 (click here to show other Interactions for entry)
Diseases: Metabolic
N-acetylglutamate synthase deficiency - [OMIM]
Homo sapiens
review
Reference: Haberle J(2011) Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency Ther Clin Risk Manag 7: 327-332 [PMID: 21941437]

Interaction Information:

Comment NAGS catalyzes the conversion of glutamate and acetyl Co-enzyme A to N-acetylglutamate, which serves as the allosteric activator of the first enzyme of the urea cycle, carbamoylphosphate synthetase 1. (cited information)
Formal Description
Interaction-ID: 53229

gene/protein

NAGS

decreases_quantity of

drug/chemical compound

Glutamate

Drugbank entries Show/Hide entries for NAGS