General Information:

Id: 44
Diseases: Parkinson disease
Synucleinopathy
Tauopathy
Homo sapiens
article
Reference: Giasson BI et al.(2003) Initiation and synergistic fibrillization of tau and alpha-synuclein Science 300: 636-640 [PMID: 12714745]

Interaction Information:

Comment Alpha-synuclein induces fibrillization of tau (MAPT).
Formal Description
Interaction-ID: 114

gene/protein

SNCA

increases_quantity of

phenotype

tau protein deposits

Comment Coincubation of tau (MAPT) and alpha-synuclein synergistically promotes fibrillization of both proteins.
Formal Description
Interaction-ID: 115

gene/protein

MAPT

increases_quantity of

phenotype

alpha-synuclein inclusion body

Comment Coincubation of beta-synuclein with tau does not promote fibrillization of tau.
Formal Description
Interaction-ID: 116

gene/protein

SNCB

NOT increases_quantity of

phenotype

tau protein deposits

Comment Alpha-synuclein induces fibrillization of tau (MAPT).
Formal Description
Interaction-ID: 118

gene/protein

SNCA

increases_folding of

gene/protein

MAPT

Comment Coincubation of tau (MAPT) and alpha-synuclein synergistically promotes fibrillization of both proteins.
Formal Description
Interaction-ID: 119

gene/protein

MAPT

increases_folding of

gene/protein

SNCA

Comment Coincubation of beta-synuclein with tau does not promote fibrillization of tau.
Formal Description
Interaction-ID: 120

gene/protein

SNCB

NOT increases_folding of

gene/protein

MAPT