General Information:

Id: 3,363
Diseases: Diabetes mellitus, type II - [OMIM]
Hypothyroidism
Insulin resistance
Rattus norvegicus
pre-diabetic Zucker diabetic fatty (ZDF) rats
article
Reference: Yi SS et al.(2010) Effects of hypothyroidism on cell proliferation and neuroblasts in the hippocampal dentate gyrus in a rat model of type 2 diabetes Anat Cell Biol 43: 185-193 [PMID: 21212858]

Interaction Information:

Comment At 12 weeks of age, corticosterone levels were significantly increased in the ZDF rats compared to those in the control (Zucker lean control, ZLC) rats.
Formal Description
Interaction-ID: 30868

organism model

ZDF rat

increases_activity of

phenotype

increased circulating corticosterone level

Comment Methimazole (methi) treatment in the ZDF rats (ZDF-methi rats) significantly decreased corticosterone levels.
Formal Description
Interaction-ID: 30869

drug/chemical compound

Thiamazole

decreases_activity of

phenotype

increased circulating corticosterone level

in ZDF rats
Comment Methimazole (methi) treatment in the ZDF rats (ZDF-methi rats) significantly decreased corticosterone levels.
Formal Description
Interaction-ID: 30870

drug/chemical compound

Thiamazole

decreases_activity of

gene/protein

TPO

in thyroid gland
Drugbank entries Show/Hide entries for TPO
Comment Methimazole (methi) treatment in the ZDF rats (ZDF-methi rats) significantly decreased corticosterone levels.
Formal Description
Interaction-ID: 30871

drug/chemical compound

Thiamazole

decreases_activity of

tissue/cell line

thyroid gland

Comment Methimazole (methi) treatment in the ZDF rats (ZDF-methi rats) significantly decreased the diabetes-induced hypertrophy of adrenal glands.
Formal Description
Interaction-ID: 30872

drug/chemical compound

Thiamazole

decreases_activity of

phenotype

enlarged adrenal glands

Comment Methimazole (methi) treatment in the ZDF rats (ZDF-methi rats) significantly decreased the diabetes-induced hypertrophy of adrenal glands.
Formal Description
Interaction-ID: 30873

disease

Diabetes mellitus, type II

increases_activity of

phenotype

enlarged adrenal glands

Comment The ZDF rat is a well-characterized genetic model of non-insulin-dependent (type 2) diabetes and obesity. ZDF rats have a defective leptin receptor. Treatment with methimazole in ZDF rats decreased the serum blood glucose levels.
Formal Description
Interaction-ID: 30874

drug/chemical compound

Thiamazole

decreases_activity of

phenotype

hyperglycemia

in ZDF rats
Comment Methimazole rescued the diabetes-induced reduction of Ki67- and DCX-immunoreactive cells. The rescue of cell proliferation and neuronal differentiation may be associated with the hypothyroidism-related reduction of corticosterone.
Formal Description
Interaction-ID: 30875

drug/chemical compound

Thiamazole

affects_activity of

process

cell population proliferation

in the hippocampal dentate gyrus
Comment Methimazole rescued the diabetes-induced reduction of Ki67- and DCX-immunoreactive cells. The rescue of cell proliferation and neuronal differentiation may be associated with the hypothyroidism-related reduction of corticosterone.
Formal Description
Interaction-ID: 30876

drug/chemical compound

Thiamazole

affects_activity of

process

cell morphogenesis involved in neuron differentiation

in the hippocampal dentate gyrus