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Field	Query

	Field	Term

General Information:

Id:	2,496
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Homo sapiens
Publication type:	article
Reference:	Orho-Melander M et al.(2008) Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 57: 3112-3121 [PMID: 18678614]

Interaction Information:

Comment	GCKR rs780094 is associated with opposite effects on fasting plasma triglyceride and glucose concentrations. In addition, we confirmed recent reports that the same SNP is associated with C-reactive protein (CRP) level.
Formal Description Interaction-ID: 23259	SNP GCKR rs780094 increases_activity of phenotype increased circulating triglyceride level

Comment	GCKR rs780094 is associated with opposite effects on fasting plasma triglyceride and glucose concentrations. In addition, we confirmed recent reports that the same SNP is associated with C-reactive protein (CRP) level.
Formal Description Interaction-ID: 23263	SNP GCKR rs780094 decreases_activity of phenotype hyperglycemia

Comment	GCKR rs780094 is associated with opposite effects on fasting plasma triglyceride and glucose concentrations. In addition, we confirmed recent reports that the same SNP is associated with C-reactive protein (CRP) level.
Formal Description Interaction-ID: 23264	SNP GCKR rs780094 increases_activity of phenotype increased circulating C-reactive protein level

Comment	Both fine-mapping approaches revealed a common missense GCKR variant (rs1260326, Pro446Leu) which was strongly associated with CRP levels.
Formal Description Interaction-ID: 23265	SNP GCKR rs1260326 increases_activity of phenotype increased circulating C-reactive protein level

Comment	GCKR coding SNP rs1260326 (Pro446Leu) gave the strongest signal for triglyceride concentrations in the associated interval on chromosome 2p23.
Formal Description Interaction-ID: 23266	SNP GCKR rs1260326 increases_activity of phenotype increased circulating triglyceride level

Comment	Neither rs780094 nor rs1260326 predicted CVD. The results were similar when age, sex, LDL cholesterol, HDL cholesterol, triglycerides, BMI, sBP, dBP, smoking, family history of myocardial infarction, lipid-lowering medication, antihypertensive medication, and CRP were included as covariates.
Formal Description Interaction-ID: 23267	SNP GCKR rs780094 NOT affects_activity of disease Cardiovascular disease

Comment	Neither rs780094 nor rs1260326 predicted CVD. The results were similar when age, sex, LDL cholesterol, HDL cholesterol, triglycerides, BMI, sBP, dBP, smoking, family history of myocardial infarction, lipid-lowering medication, antihypertensive medication, and CRP were included as covariates.
Formal Description Interaction-ID: 23268	SNP GCKR rs1260326 NOT affects_activity of disease Cardiovascular disease

Comment	In a modest number of liver samples (n = 60), neither rs780094 nor Pro446Leu genotype was associated with transcript levels of GCK or GCKR.
Formal Description Interaction-ID: 23269	SNP GCKR rs780094 NOT affects_expression of gene/protein GCK in liver
Drugbank entries	Show/Hide entries for GCK
Drugbank DB02379	Beta-D-Glucose not specified GCK
Drugbank DB07358	2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5- ... not specified GCK
Drugbank DB07359	3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl ... not specified GCK
Drugbank DB08118	2-(methylamino)-N-(4-methyl-1,3-thiazol- ... not specified GCK
Drugbank DB08210	2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZO ... not specified GCK
Drugbank DB02379	Beta-D-Glucose not specified GCK

Comment	In a modest number of liver samples (n = 60), neither rs780094 nor Pro446Leu genotype was associated with transcript levels of GCK or GCKR.
Formal Description Interaction-ID: 23270	SNP GCKR rs1260326 NOT affects_expression of gene/protein GCK in liver
Drugbank entries	Show/Hide entries for GCK
Drugbank DB02379	Beta-D-Glucose not specified GCK
Drugbank DB07358	2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5- ... not specified GCK
Drugbank DB07359	3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl ... not specified GCK
Drugbank DB08118	2-(methylamino)-N-(4-methyl-1,3-thiazol- ... not specified GCK
Drugbank DB08210	2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZO ... not specified GCK
Drugbank DB02379	Beta-D-Glucose not specified GCK

Comment	In a modest number of liver samples (n = 60), neither rs780094 nor Pro446Leu genotype was associated with transcript levels of GCK or GCKR.
Formal Description Interaction-ID: 23271	SNP GCKR rs780094 NOT affects_expression of gene/protein GCKR in liver

Comment	In a modest number of liver samples (n = 60), neither rs780094 nor Pro446Leu genotype was associated with transcript levels of GCK or GCKR.
Formal Description Interaction-ID: 23272	SNP GCKR rs1260326 NOT affects_expression of gene/protein GCKR in liver

Comment	At GCKR Pro446Leu, the variant allele is associated with higher triglycerides and higher CRP levels but also with a favorable metabolic marker, namely decreased glucose.
Formal Description Interaction-ID: 23273	SNP GCKR rs1260326 decreases_activity of phenotype hyperglycemia

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