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General Information:

Id:	1,985
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Rattus norvegicus
Gender:	male
Publication type:	article
Reference:	Carlsson PO et al.(1998) Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats Diabetologia 41: 127-133 [PMID: 9498644]

Interaction Information:

Comment	Infusion of ATII induced a dose-dependent and pronounced hypertension in all animals.
Formal Description Interaction-ID: 15574	gene/protein Angiotensin II increases_activity of phenotype hypertension

Comment	Administration of the two highest doses of ATII led to a slight hyperglycaemia.
Formal Description Interaction-ID: 15575	gene/protein Angiotensin II increases_activity of phenotype hyperglycemia if given in high doses

Comment	ATII caused a dose-dependent decrease in both whole pancreatic and islet blood flow.
Formal Description Interaction-ID: 15576	gene/protein Angiotensin II increases_activity of phenotype decreased blood flow velocity in pancreas, in pancreatic islets

Comment	Administration of enalaprilate did not affect mean arterial blood pressure or blood glucose concentrations when compared with saline-injected rats.
Formal Description Interaction-ID: 15577	drug/chemical compound Enalaprilat NOT affects_activity of process regulation of blood pressure

Comment	Administration of enalaprilate did not affect mean arterial blood pressure or blood glucose concentrations when compared with saline-injected rats.
Formal Description Interaction-ID: 15578	drug/chemical compound Enalaprilat NOT affects_quantity of drug/chemical compound Glucose in blood

Comment	After administration of enalaprilate no changes in whole pancreatic blood flow could be observed. However, the islet blood flow was markedly increased, leading to an almost doubling of the fraction of whole pancreatic blood flow being diverted through the islets.
Formal Description Interaction-ID: 15579	drug/chemical compound Enalaprilat NOT affects_activity of phenotype decreased blood flow velocity in pancreas

Comment	After administration of enalaprilate no changes in whole pancreatic blood flow could be observed. However, the islet blood flow was markedly increased, leading to an almost doubling of the fraction of whole pancreatic blood flow being diverted through the islets.
Formal Description Interaction-ID: 15580	drug/chemical compound Enalaprilat increases_activity of phenotype increased blood flow velocity in pancreatic islets

Comment	Enalaprilate is an inhibitor of angiotensin converting enzyme.
Formal Description Interaction-ID: 15581	drug/chemical compound Enalaprilat decreases_activity of gene/protein ACE
Drugbank entries	Show/Hide entries for ACE
Drugbank DB00178	Ramipril inhibitor ACE
Drugbank DB00492	Fosinopril inhibitor ACE
Drugbank DB00519	Trandolapril inhibitor ACE
Drugbank DB00542	Benazepril inhibitor ACE
Drugbank DB00584	Enalapril inhibitor ACE
Drugbank DB00616	Candoxatril inhibitor ACE
Drugbank DB00691	Moexipril inhibitor ACE
Drugbank DB00722	Lisinopril inhibitor ACE
Drugbank DB00790	Perindopril inhibitor ACE
Drugbank DB00881	Quinapril inhibitor ACE
Drugbank DB01180	Rescinnamine inhibitor ACE
Drugbank DB01197	Captopril inhibitor ACE
Drugbank DB01340	Cilazapril inhibitor ACE
Drugbank DB01348	Spirapril inhibitor ACE
Drugbank DB02032	1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrol ... not specified ACE
Drugbank DB03740	2-(Acetylamino)-2-Deoxy-a-D-Glucopyranos ... not specified ACE
Drugbank DB00178	Ramipril inhibitor ACE
Drugbank DB00492	Fosinopril inhibitor ACE
Drugbank DB00519	Trandolapril inhibitor ACE
Drugbank DB00542	Benazepril inhibitor ACE
Drugbank DB00584	Enalapril inhibitor ACE
Drugbank DB00691	Moexipril inhibitor ACE
Drugbank DB00722	Lisinopril inhibitor ACE
Drugbank DB00790	Perindopril inhibitor ACE
Drugbank DB00881	Quinapril inhibitor ACE
Drugbank DB01180	Rescinnamine inhibitor ACE
Drugbank DB02032	1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrol ... not specified ACE
Drugbank DB03740	2-(Acetylamino)-2-Deoxy-a-D-Glucopyranos ... not specified ACE

Comment	Saralasin is a competitive inhibitor of angiotensin II.
Formal Description Interaction-ID: 15582	drug/chemical compound Saralasin decreases_activity of gene/protein Angiotensin II

Comment	Saralasin selectively increased islet blood flow at the higher dose, whereas at the lower dose both whole pancreatic and islet blood flow were increased.
Formal Description Interaction-ID: 15583	drug/chemical compound Saralasin increases_activity of phenotype increased blood flow velocity in pancreas, in pancreatic islets

Comment	Mean arterial blood pressure and blood glucose concentrations were not affected by saralasin administration.
Formal Description Interaction-ID: 15584	drug/chemical compound Saralasin NOT affects_activity of process regulation of blood pressure

Comment	Mean arterial blood pressure and blood glucose concentrations were not affected by saralasin administration.
Formal Description Interaction-ID: 15585	drug/chemical compound Saralasin NOT affects_quantity of drug/chemical compound Glucose in blood

Comment	Enalaprilate affected neither basal nor glucose-stimulated insulin release, whereas angiotensin II delayed the first phase of insulin release in response to glucose. The effect of angiotensin II was probably due to initial marked vasoconstriction. The retardation of insulin release could be avoided by adding angiotensin II to the perfusion medium 20 min before glucose administration, i. e. so that the vasoconstriction had disappeared when glucose-stimulation began.
Formal Description Interaction-ID: 15586	drug/chemical compound Enalaprilat NOT affects_activity of process insulin secretion in pancreas

Comment	Enalaprilate affected neither basal nor glucose-stimulated insulin release, whereas angiotensin II delayed the first phase of insulin release in response to glucose. The effect of angiotensin II was probably due to initial marked vasoconstriction. The retardation of insulin release could be avoided by adding angiotensin II to the perfusion medium 20 min before glucose administration, i. e. so that the vasoconstriction had disappeared when glucose-stimulation began.
Formal Description Interaction-ID: 15587	gene/protein Angiotensin II affects_activity of process regulation of insulin secretion in pancreas