Robust expression of RCN2 in PVN neurons in human hypothalamus sections was found and the peak of plasma Raptin aligned with the sleep period, notably at ZT18 (1 AM). Raptin is a fragment of RCN2, spanning amino acids 28-249 of RCN2.
Robust expression of RCN2 in PVN neurons in human hypothalamus sections was found and the peak of plasma Raptin aligned with the sleep period, notably at ZT18 (1 AM). Raptin is a fragment of RCN2, spanning amino acids 28-249 of RCN2.
An RCN2 nonsense mutation contributes to night-eating syndrome. The conditioned medium from hypothalamic neurons overexpressing WT RCN2 promoted downstream AKT signaling, but this effect disappeared in neurons expressing the mutant RCN2. All three patients with obesity carrying this variant suffered from night-eating syndrome (NES), characterized by nocturnal awakenings for food intake in a fully conscious state, as reported in the questionnaires. This variant was associated with an increase in BMI, waist-to-hip ratio (WHR), and body fat in patients with NES within this family. Additionally, their serum triglycerides were elevated compared to the unaffected controls. Compared to age- and BMI-matched participants with obesity, the three patients with NES showed lower plasma Raptin levels during the night sleep phase.
An RCN2 nonsense mutation contributes to night-eating syndrome. The conditioned medium from hypothalamic neurons overexpressing WT RCN2 promoted downstream AKT signaling, but this effect disappeared in neurons expressing the mutant RCN2. All three patients with obesity carrying this variant suffered from night-eating syndrome (NES), characterized by nocturnal awakenings for food intake in a fully conscious state, as reported in the questionnaires. This variant was associated with an increase in BMI, waist-to-hip ratio (WHR), and body fat in patients with NES within this family. Additionally, their serum triglycerides were elevated compared to the unaffected controls. Compared to age- and BMI-matched participants with obesity, the three patients with NES showed lower plasma Raptin levels during the night sleep phase.
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