General Information:

Id: 15,704
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
HeLa cells; human CSF
article
Reference: [PMID: 31641056]

Interaction Information:

Comment Human CSF from APOE4/APOE4 carriers showed a lower ability to induce ABCA1-mediated cholesterol efflux activity and greater percentage of aggregated ApoE protein compared with CSF from APOE3/APOE3 carriers.
Formal Description
Interaction-ID: 148676

gene/protein mutant

APOE (genotype E4/E4)

decreases_activity of

process

ABCA1-mediated cholesterol efflux

in human CSF; compared with CSF from APOE3/APOE3 carriers
Comment Human CSF from APOE4/APOE4 carriers showed a lower ability to induce ABCA1-mediated cholesterol efflux activity and greater percentage of aggregated ApoE protein compared with CSF from APOE3/APOE3 carriers.
Formal Description
Interaction-ID: 148680

gene/protein mutant

APOE (genotype E4/E4)

increases_activity of

process

APOE aggregation

in human CSF; compared with CSF from APOE3/APOE3 carriers