CIDeRplusGeneral Information:
| Id: | 15,093 |
| Diseases: |
Ciliary dyskinesia, primary
Ciliopathy |
| Mus musculus | |
| article | |
| Reference: | [PMID: 19305393] |
Interaction Information:
| Comment | In wild-type animals, over 99% of tracheal and ependymal motile cilia showed a typical 9+2 configuration. In contrast, approximately 60% of Fu-/- cilia have abnormal ciliary ultrastructure, two-thirds of which lack the central pair apparatus. The findings indicate that mammalian Fu is dispensable for Hh signalling and specifically participates in the generation of the central pair apparatus in motile cilia axonemes. |
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Formal Description Interaction-ID: 141453 |
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| Comment | Most Fu-/- cilia moved stiffly and had a markedly reduced stroke amplitude; a subset were either immotile or beat in a slow, circular motion. In contrast to wild-type motile cilia, which beat coordinately to produce a metachronic wave, cilia in Fu-/- animals that beat seemed disoriented with respect to their neighbours. |
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Formal Description Interaction-ID: 141454 |
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| Comment | When expressed in HEK 293T cells and mouse tracheal epithelial cells (MTECs), Fu‚ÄďFlag bound strongly to Kif27‚ÄďMyc, but not to Kif7‚ÄďMyc, implicating Kif27 in the generation or regulation of 9+2 cilia. |
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Formal Description Interaction-ID: 141455 |
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| Comment | Fu and Kif27 expression are upregulated during MTEC differentiation, consistent with their essential roles in motile ciliogenesis. |
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Formal Description Interaction-ID: 141456 |
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| Comment | Fu and Kif27 expression are upregulated during MTEC differentiation, consistent with their essential roles in motile ciliogenesis. |
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Formal Description Interaction-ID: 141457 |
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| Comment | Fu‚ÄďFlag efficiently co-immunoprecipitated Spag16‚Äďhaemagglutinin (HA), but not Spag6‚ÄďHA. |
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Formal Description Interaction-ID: 141458 |
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