General Information:

Id: 1,126
Diseases: Parkinson disease
Rattus norvegicus
BTO:0001311 corpus striatum; BTO:0000143 substantia nigra
article
Reference: Chung CY et al.(2009) Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy J Neurosci 29: 3365-3373 [PMID: 19295143]

Interaction Information:

Comment A53T alpha-synuclein overexpression causes dystrophic and bulging axons.
Formal Description
Interaction-ID: 7275

gene/protein mutant

SNCA-p.A53T

increases_activity of

phenotype

axonal dystrophy

Comment Overexpression of A53T alpha-synuclein decreases striatal levels of synaptic proteins like rabphilin 3A and syntaxin.
Formal Description
Interaction-ID: 7279

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

gene/protein

RPH3A

in striatum
Comment Overexpression of A53T alpha-synuclein decreases striatal levels of synaptic proteins like rabphilin 3A and syntaxin.
Formal Description
Interaction-ID: 7280

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

gene/protein

STX1A

in striatum
Comment Overexpression of A53T alpha-synuclein decreases striatal levels of synaptic proteins like rabphilin 3A and syntaxin.
Formal Description
Interaction-ID: 7282

gene/protein

RPH3A

affects_activity of

process

chemical synaptic transmission

Comment Overexpression of A53T alpha-synuclein decreases striatal levels of synaptic proteins like rabphilin 3A and syntaxin.
Formal Description
Interaction-ID: 7283

gene/protein

STX1A

affects_activity of

process

chemical synaptic transmission

Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7284

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

gene/protein

KIF1A

in striatum
Drugbank entries Show/Hide entries for KIF1A
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7285

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

gene/protein

KIF1B

in striatum
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7286

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

gene/protein

KIF2A

in striatum
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7287

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

gene/protein

KIF3A

in striatum
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7289

gene/protein

KIF1A

affects_activity of

process

anterograde axonal transport

Drugbank entries Show/Hide entries for KIF1A
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7290

gene/protein

KIF1B

affects_activity of

process

anterograde axonal transport

Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7292

gene/protein

KIF2A

affects_activity of

process

anterograde axonal transport

Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7293

gene/protein

KIF3A

affects_activity of

process

anterograde axonal transport

Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7294

gene/protein mutant

SNCA-p.A53T

increases_quantity of

complex/PPI

Dynein complex

in striatum
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7295

gene/protein mutant

SNCA-p.A53T

increases_quantity of

gene/protein

DCTN1

in striatum
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7296

gene/protein mutant

SNCA-p.A53T

increases_quantity of

gene/protein

DCTN2

in striatum
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7297

complex/PPI

Dynein complex

affects_activity of

process

retrograde axonal transport

Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7298

gene/protein

DCTN1

affects_activity of

process

retrograde axonal transport

Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7299

gene/protein

DCTN2

affects_activity of

process

retrograde axonal transport

Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7300

gene/protein mutant

SNCA-p.A53T

increases_quantity of

gene/protein

KIF1A

in substantia nigra
Drugbank entries Show/Hide entries for KIF1A
Comment After overexpression of A53T alpha-synuclein levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and dynactin1) were increased. In contrast to reduced levels in the striatum, KIF1A and KIF2A levels were elevated in the SN.
Formal Description
Interaction-ID: 7301

gene/protein mutant

SNCA-p.A53T

increases_quantity of

gene/protein

KIF2A

in substantia nigra
Comment Overexpression of A53T alpha-synuclein causes changes in cytoskeletal protein levels, with actin levels increased and alpha-/gamma-tubulin levels reduced.
Formal Description
Interaction-ID: 7305

gene/protein mutant

SNCA-p.A53T

increases_quantity of

gene/protein

Actin

in striatum
Comment Overexpression of A53T alpha-synuclein causes changes in cytoskeletal protein levels, with actin levels increased and alpha-/gamma-tubulin levels reduced.
Formal Description
Interaction-ID: 7306

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

gene/protein

TUBA

in striatum
Comment Overexpression of A53T alpha-synuclein causes changes in cytoskeletal protein levels, with actin levels increased and alpha-/gamma-tubulin levels reduced.
Formal Description
Interaction-ID: 7308

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

gene/protein

TUBG

in striatum
Comment After transfection with A53T alpha-synuclein a neuroinflammatory response was observed at 8 weeks in the striatum, but not in the SN, demonstrated by increased levels of Iba-1, activated microglia and increased levels of proinflammatory cytokines, including IL-1beta, IFN-gamma and TNFalpha.
Formal Description
Interaction-ID: 7310

gene/protein mutant

SNCA-p.A53T

increases_activity of

process

inflammatory response

in striatum, but not in substantia nigra
Comment After transfection with A53T alpha-synuclein a neuroinflammatory response was observed at 8 weeks in the striatum, but not in the SN, demonstrated by increased levels of Iba-1, activated microglia and increased levels of proinflammatory cytokines, including IL-1beta, IFN-gamma and TNFalpha.
Formal Description
Interaction-ID: 7313

gene/protein mutant

SNCA-p.A53T

increases_activity of

process

microglial cell activation

in striatum, but not in substantia nigra