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Field	Query

	Field	Term

General Information:

Id:	10,504
Diseases:	Metabolic
Organism:	Homo sapiens
Tissue/Cell line:	HeLa cells
Publication type:	article
Reference:	Yamaji T et al.(2019) A CRISPR Screen Identifies LAPTM4A and TM9SF Proteins as Glycolipid-Regulating Factors iScience 11: 409-424 [PMID: 30660999]

Interaction Information:

Comment	Loss of LAPTM4A decreased endogenous globotriaosylceramide (Gb3) synthase activity (A4GalT) in a post-transcriptional mechanism, resulting in accumulation of its precursor lactosylceramide. Gb3 is the Shiga toxin (STx) receptor. STx is produced by enterohemorrhagic Escherichia coli and Shigella dysenteriae.
Formal Description Interaction-ID: 108494	gene/protein LAPTM4A increases_quantity of drug/chemical compound Gb3Cer by increasing endogenous Gb3 synthase activity (A4GalT) in a post-transcriptional mechanism

Comment	Loss of TM9SF2 genes reduced globotriaosylceramide (Gb3) biosynthesis, resulting in accumulation of its precursor lactosylceramide. Loss of TM9SF2 did not affect Gb3 synthase activity but instead disrupted localization of Gb3 synthase.
Formal Description Interaction-ID: 108503	gene/protein TM9SF2 increases_quantity of drug/chemical compound Gb3Cer by regulating the localization of Gb3 synthase (A4GalT)

Comment	Loss of LAPTM4A decreased endogenous globotriaosylceramide (Gb3) synthase activity (A4GalT) in a post-transcriptional mechanism, resulting in accumulation of its precursor lactosylceramide. Gb3 is the Shiga toxin (STx) receptor.
Formal Description Interaction-ID: 108504	gene/protein A4GALT decreases_quantity of drug/chemical compound Lactosylceramide

Comment	Loss of TM9SF2 genes reduced globotriaosylceramide (Gb3) biosynthesis, resulting in accumulation of its precursor, lactosylceramide. Loss of TM9SF2 did not affect Gb3 synthase activity but instead disrupted localization of Gb3 synthase.
Formal Description Interaction-ID: 108505	gene/protein TM9SF2 increases_activity of gene/protein A4GALT by regulating the localization of Gb3 synthase (A4GalT)

Comment	Loss of LAPTM4A decreased endogenous globotriaosylceramide (Gb3) synthase activity (A4GalT) in a post-transcriptional mechanism. Gb3 is the Shiga toxin (STx) receptor.
Formal Description Interaction-ID: 108507	gene/protein LAPTM4A increases_activity of gene/protein A4GALT by increasing endogenous Gb3 synthase activity (A4GalT) in a post-transcriptional mechanism

Comment	Loss of LAPTM4A decreased endogenous globotriaosylceramide (Gb3) synthase activity (A4GalT) in a post-transcriptional mechanism. Gb3 is the Shiga toxin (STx) receptor.
Formal Description Interaction-ID: 108509	gene/protein A4GALT increases_quantity of drug/chemical compound Gb3Cer

Comment	Loss of LAPTM4A decreased endogenous globotriaosylceramide (Gb3) synthase activity (A4GalT) in a post-transcriptional mechanism, resulting in accumulation of its precursor lactosylceramide. Gb3 is the Shiga toxin (STx) receptor. STx is produced by enterohemorrhagic Escherichia coli and Shigella dysenteriae.
Formal Description Interaction-ID: 108529	drug/chemical compound Gb3Cer affects_activity of process response to toxic substance since it is a receptor for Shiga toxin

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