|
61
|
| 188 |
MAPT
|
|
interacts (colocalizes) with
|
SNCA
|
in Lewy bodies
|
|
12722831
|
|
64
|
| 197 |
Insulin
|
|
increases_phosphorylation of
|
MAPT
|
|
|
9930729
|
|
122
|
| 453 |
GSK3B
|
|
increases_phosphorylation of
|
MAPT
|
|
| 685 |
GBP
|
|
decreases_phosphorylation of
|
MAPT
|
GBP binding inhibited GSK3B-mediated phosphorylation of the intact tau protein.
|
| 64421 |
Lithium
|
|
decreases_phosphorylation of
|
MAPT
|
|
|
11527574
|
|
236
|
| 980 |
GSK3B
|
|
interacts (colocalizes) with
|
MAPT
|
|
| 981 |
MAPT
|
|
decreases_expression of
|
CTNNB1
|
if MAPT is overexpressed
|
| 14039 |
MAPT
|
|
increases_activity of
|
CTNNB1
|
if cotranfected with GSK3B
|
|
1899151
|
|
397
|
| 1707 |
NIR KO mouse
|
|
increases_phosphorylation of
|
MAPT
|
in brain; at Thr231
|
| 1708 |
NIR KO mouse
|
NOT |
increases_phosphorylation of
|
MAPT
|
in brain; at Ser202
|
|
14981233
|
|
418
|
| 1983 |
Alzheimer disease
|
|
increases_phosphorylation of
|
MAPT
|
|
|
19144826
|
|
574
|
| 3041 |
GSK3B
|
|
increases_phosphorylation of
|
MAPT
|
|
| 3048 |
MAPT
|
|
interacts (colocalizes) with
|
PSEN1
|
|
|
17298085
|
|
658
|
| 3532 |
FYN
|
|
interacts (colocalizes) with
|
MAPT
|
|
|
19337449
|
|
786
|
| 4400 |
HSP70
|
|
affects_activity of
|
MAPT
|
|
| 4407 |
HSP70
|
|
interacts (colocalizes) with
|
MAPT
|
|
| 4408 |
HSP70
|
|
affects_quantity of
|
MAPT
|
|
|
19793966
|
|
792
|
| 4685 |
HSPB1
|
NOT |
interacts (colocalizes) with
|
MAPT
|
|
| 4687 |
HSPB1
|
|
increases_phosphorylation of
|
MAPT
|
at Ser262
|
| 4690 |
MAPT
|
|
interacts (colocalizes) with
|
HSP70
|
|
| 4697 |
AKT1
|
|
affects_phosphorylation of
|
MAPT
|
|
|
19449461
|
|
812
|
| 151286 |
HSP70
|
|
decreases_phosphorylation of
|
MAPT
|
in various cellular models
|
| 151287 |
HSP90
|
|
decreases_phosphorylation of
|
MAPT
|
in various cellular models
|
|
12522269
|
|
814
|
| 4704 |
STUB1
|
|
affects_ubiquitination/sumoylation of
|
MAPT
|
|
| 4705 |
STUB1
|
|
affects_quantity of
|
MAPT
|
|
| 4706 |
HSP70
|
|
affects_ubiquitination/sumoylation of
|
MAPT
|
|
| 4707 |
HSP70
|
|
affects_quantity of
|
MAPT
|
|
|
14962978
|
|
822
|
| 4753 |
HSPB1
|
|
increases_phosphorylation of
|
MAPT
|
if HSPB1/HSP27 is overexpressed
|
| 4754 |
CRYAB
|
|
decreases_phosphorylation of
|
MAPT
|
if alphaB-crystallin is overexpressed
|
|
18061943
|
|
865
|
| 145060 |
HSPB1
|
NOT |
interacts (colocalizes) with
|
MAPT
|
concerning non-phosphorylated tau
|
|
14963027
|
|
887
|
| 5233 |
MAPT
|
NOT |
interacts (colocalizes) with
|
HSPA8
|
|
| 5240 |
MAPT
|
|
is localized in
|
microtubule
|
via carboxyl end of TAU
|
| 110476 |
p25
|
|
increases_phosphorylation of
|
MAPT
|
in transgenic mouse; endogenous tau was hyperphosphorylated
|
| 110477 |
p25
|
|
increases_quantity of
|
MAPT
|
in transgenic mouse; aggregated MAPT/TAU accumulated
|
|
15615647
|
|
895
|
| 5286 |
GSK3B
|
|
increases_phosphorylation of
|
MAPT
|
|
| 5293 |
CDK5
|
|
increases_phosphorylation of
|
MAPT
|
|
| 5332 |
UBE2D2
|
|
increases_ubiquitination/sumoylation of
|
MAPT
|
|
| 87307 |
MAPT
|
|
is_part_of
|
STUB1-HSPA8-MAPT-UBE2D2 complex
|
if TAU/MAPT is hyperphosphorylated
|
|
14612456
|
|
905
|
| 5386 |
CASP1
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
| 5390 |
CASP3
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
| 5391 |
CASP6
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
| 5392 |
CASP7
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
| 5393 |
CASP8
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
| 118837 |
Amyloid beta peptide (fibrillar)
|
|
increases_processing of
|
MAPT
|
in cortical rat neurons; concerning tau proteolysis at Asp421
|
|
12888622
|
|
907
|
| 5404 |
CASP3
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
| 5406 |
CASP6
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
|
20357768
|
|
1,007
|
| 6287 |
decreased SIRT1 level
|
|
increases_quantity of
|
MAPT
|
in cerebral cortex of AD patients
|
|
19104446
|
|
1,051
|
| 6597 |
CSNK1D
|
|
interacts (colocalizes) with
|
MAPT
|
|
|
10924763
|
|
1,073
|
| 6768 |
CDK5-p25 complex
|
|
increases_phosphorylation of
|
MAPT
|
hyperphosphorylation of TAU
|
|
10604467
|
|
1,635
|
| 11981 |
MAPT
|
|
affects_activity of
|
Amyloid beta peptide
|
|
| 11982 |
MAPT
|
|
is localized in
|
microtubule
|
|
| 11983 |
MAPT
|
|
affects_activity of
|
microtubule cytoskeleton
|
|
| 11984 |
MAPT
|
|
interacts (colocalizes) with
|
FYN
|
compare CORUM: PPI=6059
|
| 11985 |
MAPT
|
|
interacts (colocalizes) with
|
DLG4
|
|
| 11986 |
MAPT
|
|
is localized in
|
axon
|
|
| 41794 |
MAPT
|
|
affects_activity of
|
FYN
|
|
|
20655099
|
|
1,636
|
| 11988 |
MAPT
|
|
is localized in
|
axon
|
|
| 11989 |
MAPT
|
|
interacts (colocalizes) with
|
microtubule
|
|
| 11993 |
Alzheimer disease
|
|
affects transport of
|
MAPT
|
from axons to neurons
|
| 11994 |
MAPT
|
|
interacts (colocalizes) with
|
neuron
|
in AD
|
| 11995 |
MAPT
|
|
interacts (colocalizes) with
|
FYN
|
|
| 11998 |
MAPT
|
|
affects_activity of
|
protein targeting
|
of Fyn to dendrites
|
|
20691893
|
|
1,780
|
| 13380 |
MAPT
|
|
affects_activity of
|
Mitochondrial respiratory chain complex I
|
|
|
19897719
|
|
1,839
|
| 13923 |
Alzheimer disease
|
|
affects_folding of
|
MAPT
|
|
|
16599941
|
|
1,870
|
| 14192 |
TTBK1
|
|
affects_phosphorylation of
|
MAPT
|
|
| 14198 |
TTBK1-Tg mouse
|
|
increases_phosphorylation of
|
MAPT
|
|
|
19118186
|
|
2,005
|
| 15910 |
MAPT
|
|
increases_activity of
|
neurodegeneration
|
isolated from AD cortex; if overexpressed
|
| 82436 |
Amyloid beta peptide (42, soluble, homodimer)
|
|
increases_phosphorylation of
|
MAPT
|
isolated from AD cortex; soluble amyloid beta-protein dimers
|
|
21421841
|
|
2,117
|
| 17339 |
high-fat diet
|
|
increases_quantity of
|
MAPT
|
|
|
18926603
|
|
2,181
|
| 18251 |
Amyloid beta peptide (endogenous)
|
|
increases_phosphorylation of
|
MAPT
|
|
|
19628305
|
|
2,246
|
| 19177 |
Simvastatin
|
NOT |
affects_quantity of
|
MAPT
|
in CSF
|
|
18376061
|
AlzNet-DB