| 419 |
GSK3B
|
|
increases_phosphorylation of
|
APP
|
activated by amyloid beta peptide
|
| 420 |
GSK3B
|
|
increases_phosphorylation of
|
APC
|
|
| 445 |
GSK3B
|
|
increases_phosphorylation of
|
IRS1
|
|
| 446 |
GSK3B
|
|
increases_phosphorylation of
|
MBP
|
|
| 447 |
GSK3B
|
|
increases_phosphorylation of
|
MAP1B
|
|
| 450 |
GSK3B
|
|
increases_phosphorylation of
|
MAP2
|
|
| 452 |
GSK3B
|
|
increases_phosphorylation of
|
NIN
|
|
| 453 |
GSK3B
|
|
increases_phosphorylation of
|
MAPT
|
|
| 454 |
GSK3B
|
|
increases_phosphorylation of
|
JUN
|
|
| 455 |
GSK3B
|
|
decreases_quantity of
|
CTNNB1
|
by phosphorylating beta-catenin, targeting it for degradation;
|
| 456 |
GSK3B
|
|
increases_phosphorylation of
|
CEBPA
|
|
| 457 |
GSK3B
|
|
increases_phosphorylation of
|
CREB1
|
|
| 458 |
GSK3B
|
|
decreases_activity of
|
HSF1
|
|
| 459 |
GSK3B
|
|
increases_phosphorylation of
|
MYC
|
the serine residues 38, 42, and 62, and threonine residue 58 within the transactivation domain of Myc.
|
| 463 |
canonical Wnt signaling pathway
|
|
affects_activity of
|
GSK3B
|
|
| 464 |
GSK3B
|
|
increases_phosphorylation of
|
AXIN1
|
|
| 465 |
GSK3B
|
|
interacts (colocalizes) with
|
APC-AXIN1-CTNNB1 complex
|
|
| 480 |
Protein phosphatase 2A
|
|
increases_activity of
|
GSK3B
|
|
| 481 |
GSK3B
|
|
increases_phosphorylation of
|
APP
|
at Thr743
|
| 482 |
GSK3B
|
|
increases_processing of
|
APP
|
|
| 487 |
GSK3B
|
|
affects_quantity of
|
Amyloid beta peptide
|
|
| 491 |
PRKAR2A
|
|
increases_phosphorylation of
|
GSK3B
|
at Ser9
|
| 492 |
GSK3B
|
|
increases_phosphorylation of
|
ACLY
|
|
| 493 |
GSK3B
|
|
increases_phosphorylation of
|
PPP1R2
|
|
| 494 |
Lithium
|
|
decreases_activity of
|
GSK3B
|
|
| 495 |
GSK3B
|
|
increases_phosphorylation of
|
EIF2B5
|
at Ser540, hereby inhibiting EIF2B5.
|
| 496 |
GSK3B
|
|
decreases_activity of
|
EIF2B5
|
by phosphorylation at Ser540.
|
| 593 |
Maleimide
|
|
decreases_activity of
|
GSK3B
|
|
| 594 |
Indirubin
|
|
decreases_activity of
|
GSK3B
|
|
| 618 |
response to heat
|
|
increases_quantity of
|
GSK3B
|
in nucleus
|
| 620 |
response to oxidative stress
|
|
decreases_activity of
|
GSK3B
|
|
| 646 |
PRKCA
|
|
increases_phosphorylation of
|
GSK3B
|
|
| 647 |
PRKCA
|
|
decreases_activity of
|
GSK3B
|
|
| 648 |
PRKCB
|
|
increases_phosphorylation of
|
GSK3B
|
hereby inactivating GSK3B.
|
| 649 |
PRKCB
|
|
decreases_activity of
|
GSK3B
|
|
| 650 |
PRKCG
|
|
increases_phosphorylation of
|
GSK3B
|
|
| 651 |
PRKCG
|
|
decreases_activity of
|
GSK3B
|
|
| 652 |
PRKCE
|
NOT |
affects_phosphorylation of
|
GSK3B
|
|
| 653 |
PRKCE
|
NOT |
decreases_activity of
|
GSK3B
|
|
| 671 |
AKT1-phosSer473Thr308
|
|
increases_phosphorylation of
|
GSK3B
|
at Ser-9, hereby reducing the activity of GSK3B.
|
| 672 |
AKT1-phosSer473Thr308
|
|
decreases_activity of
|
GSK3B
|
by phosphorylation of GSK3B at Ser9
|
| 678 |
IGF1
|
|
decreases_activity of
|
GSK3B
|
by increased Ser9 phosphorylation
|
| 679 |
EDN1
|
|
decreases_activity of
|
GSK3B
|
in myocytes; by phosphorylation of GSK3B at Ser9
|
| 680 |
EDN1
|
|
increases_phosphorylation of
|
GSK3B
|
at Ser9, hereby inhibiting GSK3B.
|
| 686 |
GBP
|
|
interacts (colocalizes) with
|
GSK3B
|
This is an important mechanism for the inhibitory control of GSK3B activity.
|
| 687 |
AXIN1
|
|
increases_activity of
|
GSK3B
|
|
| 754 |
GSK3B
|
|
increases_phosphorylation of
|
CTNNB1
|
in the absence of Wnt and if GSK3B is complexed with Axin and APC;
|
| 760 |
FRAT1
|
|
interacts (colocalizes) with
|
GSK3B
|
|
| 761 |
FRAT1
|
|
decreases_activity of
|
GSK3B
|
|
| 805 |
GSK3B
|
|
increases_phosphorylation of
|
NFATC1
|
|
| 865 |
GSK3B
|
|
increases_phosphorylation of
|
Pyruvate dehydrogenase complex
|
|
| 908 |
PSEN1
|
|
interacts (colocalizes) with
|
GSK3B
|
|
| 911 |
GSK3B
|
|
increases_activity of
|
apoptotic process
|
|
| 919 |
GSK3B
|
|
decreases_activity of
|
CREB1
|
|
| 12873 |
GSK3B
|
|
increases_phosphorylation of
|
PDP1
|
|
| 12875 |
GSK3B
|
|
interacts (colocalizes) with
|
APC
|
|
| 12876 |
GSK3B
|
|
interacts (colocalizes) with
|
AXIN1
|
|
| 12923 |
GSK3B
|
|
affects_activity of
|
MYC
|
via phosphorylation
|
| 12925 |
PRKAR2A
|
|
decreases_activity of
|
GSK3B
|
if GSK3B is phosphorylated at Ser9.
|
| 12927 |
H2O2
|
|
decreases_activity of
|
GSK3B
|
|
| 12929 |
response to heat
|
|
decreases_activity of
|
GSK3B
|
|
| 12930 |
IGF1
|
|
increases_phosphorylation of
|
GSK3B
|
at Ser9
|
| 12947 |
GSK3B
|
|
decreases_activity of
|
NFATC1
|
|
| 12948 |
GSK3B
|
|
increases_transport of
|
NFATC1
|
GSK3B phosphorylates, deactivates, and induces nuclear export of NFATc.
|
| 12957 |
GSK3B
|
|
affects_quantity of
|
Acetylcholine
|
|
| 14051 |
Amyloid beta peptide
|
|
increases_activity of
|
GSK3B
|
|
| 50125 |
IGF1
|
|
increases_phosphorylation of
|
GSK3B
|
at Ser9
|
| 72065 |
GSK3B
|
|
decreases_activity of
|
Pyruvate dehydrogenase complex
|
via phosphorylation
|
| 133776 |
GSK3B
|
|
increases_quantity of
|
PDP1-phos
|
|
| 153728 |
GSK3B
|
|
increases_quantity of
|
CREB1-phos
|
|
| 153729 |
GSK3B
|
|
increases_activity of
|
increased CREB1-phos level
|
|
AlzNet-DB