|
381
|
| 1552 |
BACE1
|
|
increases_processing of
|
APP
|
|
| 21379 |
BACE1
|
|
affects_activity of
|
amyloid-beta formation
|
|
|
12048259
|
|
952
|
| 5813 |
Insulin
|
|
affects_activity of
|
BACE1
|
|
| 5822 |
LEP
|
|
affects_activity of
|
BACE1
|
|
|
20385830
|
|
1,008
|
| 6321 |
COL25A1 TG mouse
|
|
increases_expression of
|
BACE1
|
if COL25A1 is overexpressed
|
|
19548013
|
|
1,281
|
| 8724 |
mir-107
|
|
decreases_expression of
|
BACE1
|
|
| 8725 |
Alzheimer disease
|
|
increases_quantity of
|
BACE1
|
|
|
20413881
|
|
1,377
|
| 9452 |
Oxidizing agent
|
|
increases_expression of
|
BACE1
|
|
| 9453 |
lipid oxidation
|
|
increases_expression of
|
BACE1
|
|
| 9551 |
response to oxidative stress
|
|
increases_expression of
|
BACE1
|
|
| 9552 |
Gamma-secretase complex
|
|
increases_expression of
|
BACE1
|
in a positive feedback loop
|
| 9706 |
response to hypoxia
|
|
increases_expression of
|
BACE1
|
|
| 9707 |
response to hypoxia
|
|
increases_activity of
|
BACE1
|
|
| 9740 |
HIF1A
|
|
increases_expression of
|
BACE1
|
in neuronal cells; if HIF1A is overexpressed, via binding to BACE1 promoter;
|
|
20552043
|
|
1,520
|
| 10786 |
BACE1
|
|
affects_quantity of
|
Amyloid beta peptide
|
|
| 10787 |
response to oxidative stress
|
|
increases_expression of
|
BACE1
|
|
| 10788 |
Alzheimer disease
|
|
increases_expression of
|
BACE1
|
in AD brain
|
| 10790 |
PSEN1
|
|
increases_expression of
|
BACE1
|
Oxidative stress-induced BACE1 expression is reduced in presenilin-1 (gamma-secretase)-deficient cells
|
| 10799 |
BACE1
|
|
increases_activity of
|
Alzheimer disease
|
in AD brain; Levels of beta-secretase activities were greater in brain tissue samples from AD patients compared to non-demented control subjects
|
| 10803 |
Gamma-secretase complex
|
|
affects_expression of
|
BACE1
|
at the transcriptional level
|
|
18687504
|
|
1,522
|
| 10800 |
Gamma-secretase complex
|
|
increases_expression of
|
BACE1
|
in brain; of 3xTgAD mouse
|
|
18687504
|
|
1,576
|
| 11352 |
Alzheimer disease
|
|
affects_quantity of
|
BACE1
|
|
| 11353 |
Reactive oxygen species
|
|
increases_expression of
|
BACE1
|
if ROS is overexpressed
|
| 11355 |
Gamma-secretase complex
|
|
increases_activity of
|
BACE1
|
|
|
20442493
|
|
1,831
|
| 13844 |
mir-29a
|
|
affects_expression of
|
BACE1
|
|
| 13851 |
mir-29b-1
|
|
affects_expression of
|
BACE1
|
|
| 13852 |
mir-9
|
|
affects_expression of
|
BACE1
|
|
| 13855 |
Alzheimer disease
|
|
increases_expression of
|
BACE1
|
|
|
18434550
|
|
1,935
|
| 14887 |
BACE1
|
|
increases_processing of
|
APP
|
|
| 14932 |
BACE1
|
|
increases_activity of
|
amyloid-beta formation
|
|
|
16025111
|
|
1,957
|
| 15248 |
2-Deoxy-D-glucose
|
|
increases_quantity of
|
BACE1
|
in Tg2576 transgenic mice
|
| 15249 |
Insulin
|
|
increases_quantity of
|
BACE1
|
in Tg2576 transgenic mice
|
| 15250 |
beta-Nitropropanoate
|
|
increases_quantity of
|
BACE1
|
in Tg2576 transgenic mice
|
| 15251 |
Kainic acid
|
|
increases_quantity of
|
BACE1
|
in Tg2576 transgenic mice
|
|
19076444
|
|
2,130
|
| 17532 |
NOS3
|
|
decreases_quantity of
|
BACE1
|
|
|
21127294
|
|
2,136
|
| 17742 |
BACE1
|
|
increases_quantity of
|
Amyloid beta peptide (15)
|
experimentally concluded via treatment with alpha- and beta-secretase inhibitors.
|
| 17743 |
BACE1
|
|
increases_quantity of
|
Amyloid beta peptide (14)
|
experimentally concluded via treatment with alpha- and beta-secretase inhibitors.
|
| 17749 |
BACE1
|
|
increases_quantity of
|
sAPP-alpha
|
|
| 17750 |
BACE1
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
compared with vehicle or untreated cells.
|
| 17751 |
BACE1
|
|
decreases_quantity of
|
Amyloid beta peptide (40)
|
compared with vehicle or untreated cells.
|
| 17752 |
BACE1
|
|
decreases_quantity of
|
Amyloid beta peptide (38)
|
compared with vehicle or untreated cells.
|
| 17753 |
BACE1
|
|
decreases_quantity of
|
Amyloid beta peptide (14)
|
compared with vehicle or untreated cells.
|
| 17812 |
BACE1
|
|
decreases_quantity of
|
Amyloid beta peptide (15)
|
compared with vehicle or untreated cells.
|
| 17813 |
BACE1
|
|
decreases_quantity of
|
Amyloid beta peptide (16)
|
compared with vehicle or untreated cells.
|
|
19604603
|
|
2,249
|
| 19236 |
Atorvastatin
|
|
decreases_quantity of
|
BACE1
|
|
|
21536132
|
|
2,269
|
| 19403 |
Cholesterol
|
|
increases_activity of
|
BACE1
|
in aged dog brains; BACE1 protein levels and activity decreased and correlated with reduced brain cholesterol
|
| 19404 |
Cholesterol
|
|
increases_quantity of
|
BACE1
|
in aged dog brains; BACE1 protein levels and activity decreased and correlated with reduced brain cholesterol
|
|
20847439
|
|
2,278
|
| 19542 |
Pioglitazone
|
|
decreases_expression of
|
BACE1
|
in APP transgenic mice
|
| 28111 |
BACE1
|
|
affects_processing of
|
APP
|
|
| 28112 |
BACE1
|
|
increases_quantity of
|
sAPP-beta
|
|
|
21345168
|
|
2,309
|
| 19935 |
ST101
|
NOT |
affects_quantity of
|
BACE1
|
|
|
21416488
|
|
2,351
|
| 20578 |
NGF
|
|
decreases_expression of
|
BACE1
|
through binding to the NGF high affinity receptor TrkA
|
|
21321391
|
|
2,533
|
| 23825 |
Cholesterol
|
|
increases_activity of
|
BACE1
|
|
| 24060 |
BACE1
|
|
interacts (colocalizes) with
|
membrane raft
|
Cholesterol depletion decreases the association of BACE1 with lipid rafts.
|
| 24086 |
BACE1
|
|
interacts (colocalizes) with
|
APP
|
in lipid raft domains; promoted by cholesterol
|
| 24130 |
Sphingolipid
|
|
affects_activity of
|
BACE1
|
|
|
21448224
|
|
2,587
|
| 24431 |
Myricetin
|
|
decreases_activity of
|
BACE1
|
by direct binding and inhibition
|
| 82427 |
Myricetin
|
|
interacts (colocalizes) with
|
BACE1
|
|
|
17722071
|
|
2,593
|
| 24465 |
Bepridil
|
|
decreases_activity of
|
BACE1
|
|
| 24466 |
Amiodarone
|
|
decreases_activity of
|
BACE1
|
|
| 24472 |
pH elevation
|
|
decreases_activity of
|
BACE1
|
|
| 24473 |
BACE1
|
|
increases_processing of
|
APP
|
in the acidic endosomes
|
| 82428 |
response to acidic pH
|
|
increases_activity of
|
BACE1
|
in the acidic endosomes
|
| 82429 |
BACE1
|
|
decreases_quantity of
|
APP
|
in the acidic endosomes; via cleaving APP
|
| 124622 |
pH reduction
|
|
increases_activity of
|
BACE1
|
in the acidic endosomes
|
|
20592218
|
|
2,600
|
| 24593 |
EIF2A-P
|
|
increases_expression of
|
BACE1
|
EIF2A-P is activated form of EIF2A
|
| 24607 |
Salubrinal
|
|
increases_quantity of
|
BACE1
|
|
|
19109907
|
|
2,673
|
| 25115 |
BACE1
|
|
increases_processing of
|
APLP2
|
|
| 82430 |
BACE1
|
|
decreases_quantity of
|
APLP2
|
|
|
21695060
|
|
3,079
|
| 28298 |
Heparan sulfate
|
|
decreases_activity of
|
BACE1
|
|
|
21715329
|
|
3,093
|
| 28388 |
PRNP
|
|
interacts (colocalizes) with
|
BACE1
|
with the prodomain of the immature Golgi-localized form of BACE1
|
| 28391 |
BACE1
|
|
interacts (colocalizes) with
|
cell surface
|
|
| 28428 |
BACE1
|
|
interacts (colocalizes) with
|
endosome
|
|
| 28429 |
BACE1
|
|
increases_processing of
|
APP
|
at cell surface, in endosomes, and Golgi; depending on the interaction of PrPC and BACE1
|
| 28430 |
BACE1
|
|
is localized in
|
trans-Golgi network
|
|
| 28432 |
PRNP
|
|
affects_activity of
|
BACE1
|
by binding to the prodomain of the immature Golgi-localized form of BACE1
|
|
21795680
|
|
3,104
|
| 28485 |
PRNP
|
|
interacts (colocalizes) with
|
BACE1
|
|
| 28493 |
PRNP
|
|
decreases_activity of
|
BACE1
|
This decreases both Abeta and AICD (amyloid intracellular domain) production.
|
| 29033 |
Alzheimer disease
|
|
affects_activity of
|
BACE1
|
|
|
19887909
|
|
3,212
|
| 29666 |
12/15-Lipoxygenase
|
|
affects_expression of
|
BACE1
|
BACE1 mRNA expression level is regulated via the activation of the transcription factor Sp1
|
| 29667 |
SP1
|
|
affects_expression of
|
BACE1
|
BACE1 mRNA expression level is regulated via the activation of the transcription factor Sp1.
|
| 29669 |
BACE1
|
|
affects_quantity of
|
Amyloid beta peptide
|
transcriptionally regulated by by 12/15-lipoxygenase
|
| 29670 |
BACE1
|
|
affects_activity of
|
cognitive impairment
|
transcriptionally regulated by 12/15-lipoxygenase.
|
|
22275252
|
|
3,374
|
| 31373 |
mir-124
|
|
affects_expression of
|
BACE1
|
|
|
22178568
|
|
3,382
|
| 31475 |
BACE1
|
|
affects_activity of
|
regulation of proteolysis
|
of APP
|
| 31482 |
BACE1
|
|
increases_activity of
|
membrane protein ectodomain proteolysis
|
of APP
|
| 111482 |
BACE1
|
|
increases_processing of
|
APP
|
via catalyzing the extracellular cleavage
|
| 143840 |
BACE1
|
|
increases_activity of
|
APP ectodomain proteolysis
|
|
|
22506131
|
|
3,414
|
| 31699 |
aging
|
|
increases_activity of
|
BACE1
|
|
| 31846 |
APP (intracellular domain AICD)
|
|
increases_expression of
|
BACE1
|
|
| 52845 |
BACE1
|
|
increases_quantity of
|
APP (CTF-C99)
|
|
| 52859 |
Alzheimer disease
|
|
increases_activity of
|
BACE1
|
|
|
22122663
|
AlzNet-DB