|
322
|
| 1268 |
NCSTN-mut
|
|
increases_quantity of
|
Amyloid beta peptide (42)
|
increased gamma-secretase cleavage by missense mutations in a conserved hydrophilic domain of nicastrin (NCSTN);
|
|
10993067
|
|
381
|
| 14074 |
NCSTN
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
|
| 21385 |
amyloid-beta formation
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
|
|
12048259
|
|
427
|
| 1884 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
AKT1-PDPK1 interaction
|
interaction of PDK with Akt1 is interrupted by intracellular beta-amyloid42
|
| 2001 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
AKT1
|
concerning activity of Akt1 on the GSK substrate
|
| 134774 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
Insulin
|
in cell culture; concerning intraneuronal beta-amyloid
|
|
19144826
|
|
520
|
| 2586 |
Gamma-secretase complex
|
|
increases_quantity of
|
Amyloid beta peptide (42)
|
|
|
12846562
|
|
574
|
| 3018 |
Amyloid beta peptide (42)
|
|
increases_quantity of
|
amyloid beta deposits
|
|
|
17298085
|
|
580
|
| 26738 |
GSK3A
|
|
increases_quantity of
|
Amyloid beta peptide (42)
|
|
| 64426 |
GSK3B
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
|
12761548
|
|
658
|
| 3512 |
Amyloid beta peptide (42)
|
|
increases_quantity of
|
amyloid beta deposits
|
|
| 3528 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
mitochondrion
|
|
| 80152 |
Amyloid beta peptide (42)
|
|
increases_quantity of
|
Amyloid beta peptide (fibrillar)
|
|
|
19337449
|
|
704
|
| 3868 |
Amyloid beta peptide (42)
|
|
interacts (colocalizes) with
|
Amyloid beta peptide (42)
|
dimerisation of amyloid beta(42) peptide
|
| 3871 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
Abeta (42) homodimerization
|
|
|
15659604
|
|
717
|
| 10902 |
Lithium
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
| 10903 |
Valproic acid
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
|
15170327
|
|
718
|
| 5839 |
Lithium
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
| 5840 |
Valproic acid
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
|
15170327
|
|
750
|
| 4225 |
SOD1
|
|
interacts (colocalizes) with
|
Amyloid beta peptide (42)
|
|
| 4227 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
Amyloid beta peptide (42)
|
|
| 4240 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
SOD1
|
|
| 4242 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
SOD1-p.G93A
|
|
|
19478559
|
|
792
|
| 4546 |
APP-mut
|
|
increases_processing of
|
Amyloid beta peptide (42)
|
in extracellular milieu; if APP-mut is overexpressed
|
| 4547 |
PSEN1-mut
|
|
increases_processing of
|
Amyloid beta peptide (42)
|
in extracellular milieu; if PSEN1-mut is overexpressed
|
|
19449461
|
|
908
|
| 10906 |
response to oxidative stress
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
|
|
19191039
|
|
948
|
| 5833 |
Ginsenoside Re
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
in brain
|
| 5834 |
Ginsenoside Rg1
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
in brain
|
| 5835 |
Ginsenoside Rg3
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
in brain
|
|
16636099
|
|
949
|
| 5767 |
Ginsenoside Rg1
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
| 5769 |
Ginsenoside Re
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
| 5770 |
Ginsenoside F11
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
| 5771 |
Ginsenoside Rg3
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
| 5773 |
Ginsenoside Rb1
|
NOT |
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
| 5774 |
Ginsenoside Rb2
|
NOT |
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
| 5778 |
American ginseng
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
Panax quinquefolius (American ginseng)
|
| 5779 |
Chinese ginseng
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
|
16636099
|
|
950
|
| 5841 |
Allium sativum (garlic) supplementation
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
|
|
15277073
|
|
990
|
| 6147 |
TgCRND8 mouse
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
|
|
17380553
|
|
1,001
|
| 6216 |
pomegranate juice supplementation
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
in hippocampus
|
|
17010630
|
|
1,057
|
| 6704 |
PS cDKO mouse
|
|
decreases_expression of
|
Amyloid beta peptide (42)
|
in cerebral cortex
|
|
15345711
|
|
1,107
|
| 154871 |
Amyloid beta peptide (42)
|
|
increases_quantity of
|
amyloid beta deposits
|
in AD brain
|
|
20462385
|
|
1,183
|
| 11489 |
CSNK1E
|
|
increases_quantity of
|
Amyloid beta peptide (42)
|
in brain (BTO:0000142); if CSNK1E is overexpressed
|
| 11490 |
IC261
|
|
decreases_quantity of
|
Amyloid beta peptide (42)
|
in brain (BTO:0000142)
|
|
17360493
|
|
1,190
|
| 7937 |
Amyloid beta peptide (42)
|
|
increases_expression of
|
mir-376b
|
|
| 7938 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-409-3p
|
|
| 7939 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-20b
|
|
| 7940 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-9
|
|
| 7941 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-181c
|
|
| 7942 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
let-7i
|
|
| 7943 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-30c
|
|
| 7944 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-148b
|
|
| 7945 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-182
|
|
| 7946 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-137
|
|
| 7947 |
Amyloid beta peptide (42)
|
|
decreases_expression of
|
mir-361
|
|
|
20552018
|
|
1,257
|
| 8504 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
GLUL
|
in cytosolic fractions of brain homogenates and in cultured hippocampal neurons and astrocytes
|
| 8506 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
Creatine kinase
|
|
| 8507 |
alpha-Tocopherol
|
|
decreases_activity of
|
Amyloid beta peptide (42)
|
|
| 8513 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
Alzheimer disease
|
|
| 8514 |
APP-mut
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
|
| 8515 |
PSEN1-mut
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
|
| 8516 |
PSEN2-mut
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
|
| 8517 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
neuron death
|
|
|
11733217
|
|
1,333
|
| 9114 |
PSEN1-mut
|
|
increases_quantity of
|
Amyloid beta peptide (42)
|
|
| 9122 |
PSEN1-mut
|
NOT |
increases_activity of
|
Amyloid beta peptide (42)
|
|
|
20594619
|
|
1,511
|
| 10762 |
Amyloid beta peptide (42)
|
|
interacts (colocalizes) with
|
Zn2+
|
|
| 10875 |
Amyloid beta peptide (42)
|
|
interacts (colocalizes) with
|
Cu2+
|
|
| 10877 |
Amyloid beta peptide (42)
|
|
interacts (colocalizes) with
|
Fe3+
|
|
| 10910 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
metal ion binding
|
|
| 10911 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
copper ion binding
|
|
| 10912 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
zinc ion binding
|
|
| 10913 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
iron ion binding
|
|
|
16205720
|
|
1,582
|
| 11391 |
Amyloid beta peptide (42)
|
|
is localized in
|
mitochondrial matrix
|
|
| 11394 |
Amyloid beta peptide (42)
|
|
is localized in
|
mitochondrial inner membrane
|
|
| 11412 |
Amyloid beta peptide (42)
|
|
increases_quantity of
|
amyloid beta deposits
|
|
|
16551656
|
|
1,628
|
| 11920 |
TOM complex, mitochondrial
|
|
increases_transport of
|
Amyloid beta peptide (42)
|
into mitochondrial cristae
|
| 11940 |
Amyloid beta peptide (42)
|
|
is localized in
|
mitochondrial crista
|
transported via TOM complex
|
|
18757748
|
|
1,630
|
| 11943 |
TOM complex, mitochondrial
|
|
increases_transport of
|
Amyloid beta peptide (42)
|
into mitochondria
|
| 11947 |
Amyloid beta peptide (42)
|
|
is localized in
|
mitochondrial crista
|
|
|
18757748
|
|
1,688
|
| 12714 |
mir-17
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
and thus effects Abeta x-42/Alpha beta x-40 peptide ratio
|
|
20888417
|
|
1,820
|
| 13642 |
Amyloid beta peptide (42)
|
|
decreases_activity of
|
astroglial cell
|
|
| 13677 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
response to stress
|
|
|
20937840
|
AlzNet-DB