|
7,322
|
| 85052 |
oophorectomy
|
|
decreases_quantity of
|
Testosterone
|
if bilateral and prior to menopause
|
|
24470773
|
|
7,457
|
| 73412 |
Testosterone
|
|
increases_activity of
|
verbal episodic memory
|
in ApoE4+ carriers in a group of participants in the Vietnam Era Twin Study of Aging
|
| 73416 |
Testosterone
|
NOT |
affects_activity of
|
verbal episodic memory
|
in ApoE4- carriers in a group of participants in the Vietnam Era Twin Study of Aging
|
|
24444806
|
|
7,459
|
| 73442 |
APOD
|
|
interacts (colocalizes) with
|
Testosterone
|
|
|
21423873
|
|
7,522
|
| 74177 |
Testosterone
|
|
increases_activity of
|
spartial memory
|
in APOA4 female mice
|
| 74183 |
Testosterone
|
|
interacts (colocalizes) with
|
AR
|
|
|
18395206
|
|
8,023
|
| 79399 |
Testosterone
|
|
decreases_activity of
|
Amyloid beta peptide
|
|
| 79412 |
Testosterone
|
|
increases_activity of
|
oxidative phosphorylation
|
when Abeta-induced
|
|
26198711
|
|
8,658
|
| 90183 |
Testosterone
|
NOT |
affects_quantity of
|
Docosahexaenoic acid
|
via precursor alpha-linolenic acid (ALA)
|
|
29559883
|
|
8,746
|
| 91062 |
Testosterone
|
NOT |
affects_expression of
|
APP695
|
in adult male mice after gonadectomy; concerning APP695 mRNA
|
| 91081 |
Testosterone
|
|
increases_expression of
|
APP695
|
in old male and adult female mice after gonadectomy; concerning APP695 mRNA;
|
| 91082 |
Testosterone
|
|
decreases_expression of
|
APP695
|
in old female mice after gonadectomy; concerning APP695 mRNA;
|
|
15882808
|
|
8,808
|
| 92024 |
Rheumatoid arthritis
|
|
decreases_quantity of
|
Testosterone
|
in men
|
|
10718932
|
|
12,544
|
| 121994 |
Testosterone
|
|
increases_activity of
|
inflammatory response
|
testosterone can promote inflammatory signals via interaction with microglia
|
| 121997 |
Testosterone
|
|
increases_activity of
|
increased supernatant nitrite leve
|
after treatment of microglia and peritoneal macrophages,
indicative of a pro-inflammatory effect
|
| 122004 |
APOE (isoform E4)
|
|
decreases_quantity of
|
Testosterone
|
in normal males / men who are APOE4 carriers; compared to males / men who are not APOE4 carriers
|
|
17395708
|
|
12,549
|
| 122045 |
APOE (isoform E4)
|
|
increases_activity of
|
Testosterone
|
in middle-aged APOE4 carriers ; free testosterone was positively associated with one indicator of verbal episodic memory performance; in APOE4 non-carriers no association was observed
|
| 122047 |
Testosterone
|
|
increases_activity of
|
verbal episodic memory
|
in middle-aged male APOE4 carriers ; free testosterone was positively associated with one indicator of verbal episodic memory performance; in APOE4 non-carriers no association was observed
|
| 129165 |
Testosterone
|
NOT |
affects_activity of
|
verbal episodic memory
|
in middle-aged male APOE4 non-carriers ; free testosterone was positively associated with one indicator of verbal episodic memory performance; in APOE4 non-carriers no association was observed
|
|
24444806
|
|
12,556
|
| 122212 |
sex
|
|
affects_quantity of
|
Testosterone
|
in plasma
|
| 122259 |
Testosterone
|
|
increases_quantity of
|
AR
|
in the neocortex of female apoE4 mice
|
| 122261 |
Testosterone
|
|
increases_quantity of
|
Estradiol
|
|
| 122270 |
Testosterone
|
|
decreases_activity of
|
abnormal spatial working memory
|
in female apoE4 mice; but not in female apoE3 mice
|
| 122272 |
aging
|
|
decreases_quantity of
|
Testosterone
|
in males / men and females / women; concerning plasma testosterone levels
|
| 122285 |
Testosterone
|
|
decreases_activity of
|
APOE (isoform E4)
|
in female apoE4 mice; but not in female apoE3 mice, concerning spatial learning and memory
|
| 122286 |
Testosterone
|
NOT |
affects_activity of
|
APOE (isoform E3)
|
in female apoE3 mice; concerning spatial learning and memory
|
| 122307 |
Testosterone
|
|
increases_activity of
|
cognition
|
in women rendered menopausal by surgery ; testosterone therapy improved cognition
|
| 122308 |
Testosterone
|
|
increases_activity of
|
learning or memory
|
in adult female apoE4 mice
|
| 124543 |
APOE (isoform E4)
|
|
increases_activity of
|
Testosterone
|
in the neocortex of female apoE4 mice; concerning increased AR levels via testosterone and dihydrotestosterone
|
| 139509 |
sex, female
|
|
increases_activity of
|
Testosterone
|
in the neocortex of female apoE4 mice; concerning increased AR levels via testosterone and dihydrotestosterone
|
|
12077215
|
|
13,075
|
| 124381 |
APOE (isoform E4)
|
|
interacts (colocalizes) with
|
Testosterone
|
concerning hippocampal volume
|
| 128880 |
Testosterone
|
|
interacts (colocalizes) with
|
AR
|
reduced in mice that express the APOE4 allele
|
| 128887 |
Testosterone
|
|
is_part_of
|
Testosterone-AR interaction
|
in APOE4 mice
|
|
20819998
|
|
13,668
|
| 128541 |
Testosterone
|
|
increases_activity of
|
increased mitochondrial bioenergetics
|
|
|
32444841
|
|
13,714
|
| 128770 |
aging
|
|
decreases_quantity of
|
Testosterone
|
in aging men; an age-related gradual loss of testosterone and an increase in testosterone resistance has been shown
|
| 128775 |
premenopause
|
|
affects_activity of
|
Testosterone
|
in premenopausal women; increased testosterone levels induces insulin resistance
|
| 128780 |
menopause
|
NOT |
affects_quantity of
|
Testosterone
|
in women; natural menopause
|
| 128781 |
Testosterone
|
|
decreases_activity of
|
GSK3B
|
in female rats; testosterone prevents heat-shock induced over-activation of GSK3B
|
| 128782 |
Testosterone
|
|
increases_activity of
|
insulin secretion
|
in human pancreatic beta cells and male mouse islet; via AR
|
| 128785 |
Testosterone
|
|
affects_expression of
|
MME
|
|
| 128787 |
Testosterone
|
|
increases_expression of
|
MME
|
in neurons; through an AR-dependent mechanism which in turn decreases Abeta, upregulation of IDE and NEP may also have a beneficial effect on the levels, toxicity or fibrillization of amylin
|
| 128788 |
Testosterone
|
|
increases_expression of
|
IDE
|
in hyperinsulinemic castrated rats; upregulation of IDE and NEP may also have a beneficial effect on the levels, toxicity or fibrillization of amylin
|
| 128856 |
sex, female
|
|
affects_activity of
|
Testosterone
|
in premenopausal women
|
| 128857 |
sex, male
|
|
affects_activity of
|
Testosterone
|
in aging men
|
| 128875 |
Testosterone
|
|
affects_activity of
|
sex, male
|
in men
|
| 128876 |
Testosterone
|
|
affects_activity of
|
sex, female
|
in women
|
| 128877 |
Testosterone
|
|
increases_quantity of
|
Estrogen
|
in women; estrogen is made from testosterone and other adrenal hormones
|
| 128878 |
Testosterone
|
|
decreases_phosphorylation of
|
MAPT
|
in female rats; via preventing heat-shock induced over-activation of GSK3B
|
| 128879 |
Testosterone
|
|
is localized in
|
brain
|
in female rats; via the blood brain barrier using a receptor-mediated transport system
|
| 128888 |
Testosterone
|
|
increases_activity of
|
AR
|
in human pancreatic beta cells and male mouse islet; testosterone activated AR-enhancing insulin secretion is through the interaction between extranuclear AR and the glucagon-like peptide 1
|
| 128912 |
Testosterone
|
|
affects_activity of
|
IAPP
|
upregulation of IDE and NEP via testosterone may have a beneficial effect on the levels, toxicity or fibrillization of amylin
|
|
28655134
|
|
13,729
|
| 128931 |
Testosterone
|
|
affects_activity of
|
SLC2A4
|
by modification of GLUT4 and increased expression of insulin receptor protein
|
| 128932 |
Testosterone
|
|
increases_activity of
|
AR
|
in the brain, skeletal muscle, liver, adipose tissue, and pancreatic islet beta-cells for maintenance in glucose homeostasis; concerning sex-specific activation of the AR, for maintenance in glucose homeostasis
|
| 128935 |
Testosterone
|
|
increases_expression of
|
INSR
|
by modification of GLUT4 and increased expression of insulin receptor protein
|
| 128936 |
Testosterone
|
|
increases_activity of
|
glucose homeostasis
|
in the brain, skeletal muscle, liver, adipose tissue, and pancreatic islet beta-cells for maintenance in glucose homeostasis; concerning sex-specific activation of the AR
|
| 128938 |
Testosterone
|
|
increases_activity of
|
glucose import
|
in adipocytes; via LKB1/STK11 -AMPK signaling
|
| 128939 |
Testosterone
|
|
increases_activity of
|
SLC2A4 translocation
|
in adipocytes; via LKB1/STK11 -AMPK signaling
|
| 129141 |
sex, female
|
|
increases_activity of
|
Testosterone
|
in APOE4 female mice; compared to APOE4 male mice
|
| 129143 |
Testosterone
|
|
increases_activity of
|
memory
|
in APOE4 female mice
|
| 129147 |
Testosterone
|
|
decreases_activity of
|
response to oxidative stress
|
in the SAMP8 mouse model of aging; potentially via upregulating expression of SIRT1
|
| 129148 |
Testosterone
|
|
affects_activity of
|
cell redox homeostasis
|
|
| 129164 |
sex, male
|
|
decreases_activity of
|
Testosterone
|
in APOE4 male mice; compared to APOE4 female mice
|
| 129260 |
Testosterone
|
|
decreases_activity of
|
BACE1
|
in male APP23 transgenic mice (ArKO √ó APP23); by genetically targeting aromatase
|
|
28655134
|
|
13,811
|
| 129817 |
Testosterone
|
|
increases_activity of
|
positive regulation of mitochondrial membrane potential
|
in the CNS in a human astrocyte cell model; acting via positive regulation of neuroglobin
|
| 129819 |
Testosterone
|
|
decreases_activity of
|
nuclear fragmentation involved in apoptotic nuclear change
|
in the CNS in a human astrocyte cell model; acting via positive regulation of neuroglobin
|
| 129820 |
Testosterone
|
|
affects_activity of
|
Reactive oxygen species
|
the effects of testosterone upon oxidative status are still controversial, ranging from ROS generation to scavenging or chain breaking of ROS and RNS
|
| 129821 |
Testosterone
|
|
increases_activity of
|
brain capillary
|
guaranteeing cerebral homeostasis in males
|
|
|
|
14,875
|
| 139562 |
APOE (isoform E4)
|
|
affects_activity of
|
Testosterone
|
in male APOE4 carriers; both low serum testosterone and the interaction between testosterone and APOE4 were associated with AD
|
|
12325053
|
|
14,876
|
| 139563 |
Testosterone
|
|
increases_activity of
|
increased cognitive function
|
in older women
|
|
10573435
|
AlzNet-DB