|
2,533
|
| 24095 |
Sphingomyelin
|
|
is localized in
|
membrane raft
|
|
| 24099 |
Sphingomyelinase
|
|
decreases_quantity of
|
Sphingomyelin
|
|
| 77660 |
Sphingomyelin
|
|
decreases_activity of
|
Gamma-secretase complex
|
|
| 77661 |
Sphingomyelin
|
|
decreases_activity of
|
Abeta secretion
|
due to inhibition of gamma-secretase activity
|
| 79969 |
sphingomyelin catabolic process
|
|
decreases_quantity of
|
Sphingomyelin
|
|
|
21448224
|
|
7,238
|
| 71213 |
Sphingomyelin
|
|
increases_activity of
|
Alzheimer disease
|
in plasma; among men in the Baltimore Longitudinal Study of Aging;
|
| 71215 |
Sphingomyelin
|
|
decreases_activity of
|
Alzheimer disease
|
in plasma; among women, most pronounced among APOE (isoform E4) carriers, in the Baltimore Longitudinal Study of Aging;
|
| 71258 |
sex
|
|
affects_activity of
|
Sphingomyelin
|
in plasma; concerning the risk of AD among men and women in the Baltimore Longitudinal Study of Aging;
|
| 71264 |
APOE (isoform E4)
|
NOT |
affects_activity of
|
Sphingomyelin
|
in plasma; concerning the risk of AD among men in the Baltimore Longitudinal Study of Aging;
|
|
|
|
7,757
|
| 77658 |
Sphingomyelin
|
|
is localized in
|
myelin sheath
|
of neurons and lipid rafts of cell membranes
|
| 77659 |
Sphingomyelin synthase
|
|
increases_quantity of
|
Sphingomyelin
|
There are two sphingomyelin synthases: SGMS1 and SGMS2
|
| 77662 |
Sphingomyelinase
|
|
decreases_quantity of
|
Sphingomyelin
|
via degrading SM and forming Cer and choline
|
| 77669 |
Sphingomyelin
|
|
increases_quantity of
|
Ceramide
|
Catabolism of SM forms Ceramide
|
|
25938590
|
|
7,815
|
| 77883 |
aging
|
|
affects_quantity of
|
Sphingomyelin
|
in CSF
|
| 77885 |
sex
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in CSF
|
| 77888 |
Vitamin
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in CSF
|
| 77890 |
blood pressure medication
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in CSF
|
| 77892 |
increased body mass index
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in CSF
|
| 77894 |
fasting serum cholesterol
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in CSF
|
| 77896 |
Triacylglycerol
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in CSF
|
| 77898 |
Glucose
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in CSF
|
| 77903 |
Sphingomyelin
|
|
affects_quantity of
|
MAPT
|
in CSF; positively correlated; increased by aging and APOE4
|
| 77904 |
Sphingomyelin
|
|
affects_quantity of
|
MAPT-phos181
|
in CSF; positively correlated
|
| 77905 |
Sphingomyelin
|
|
affects_activity of
|
MAPT/Abeta42 ratio
|
in CSF; positively correlated
|
|
24952994
|
|
7,820
|
| 77787 |
Alzheimer disease, prodromal
|
|
increases_quantity of
|
Sphingomyelin
|
in CSF
|
|
20953867
|
|
7,821
|
| 80770 |
N-Acylsphingosine
|
|
increases_quantity of
|
Sphingomyelin
|
|
| 80856 |
sphingomyelin catabolic process
|
|
decreases_quantity of
|
Sphingomyelin
|
catabolism of sphingomyelin
|
| 80864 |
Sphingomyelinase
|
|
decreases_quantity of
|
Sphingomyelin
|
catabolism of sphingomyelin, via hydrolyzing the phosphodiester bond of sphingomyelin
|
| 80888 |
Glycerophosphocholine
|
|
increases_quantity of
|
Sphingomyelin
|
via transferring a phosphocholine head group from phosphatidylcholine (Glycerophosphocholine) onto ceramide by the enzyme phosphatidylcholine transferase (sphingomyelin synthase)
|
| 80890 |
Phosphatidylcholine
|
|
increases_quantity of
|
Sphingomyelin
|
via transferring a phosphocholine head group from phosphatidylcholine (Glycerophosphocholine) onto ceramide by the enzyme phosphatidylcholine transferase (sphingomyelin synthase)
|
| 80891 |
Sphingomyelin synthase
|
|
increases_quantity of
|
Sphingomyelin
|
|
| 81336 |
Sphingomyelin
|
|
is localized in
|
membrane raft
|
in neuron
|
| 81551 |
Myriocin
|
|
decreases_quantity of
|
Sphingomyelin
|
|
| 81567 |
sphingomyelin catabolic process
|
|
decreases_quantity of
|
Sphingomyelin
|
e.g. via acid sphingomyelin hydrolysis
|
|
20452460
|
|
7,824
|
| 78101 |
Alzheimer disease
|
|
decreases_quantity of
|
Sphingomyelin
|
|
| 78136 |
Sphingomyelin
|
|
is localized in
|
membrane fraction
|
of both normal and AD brain
|
|
18547682
|
|
7,825
|
| 79576 |
SGMS1
|
|
increases_quantity of
|
Sphingomyelin
|
|
|
17342407
|
|
7,827
|
| 79460 |
Alzheimer disease
|
|
increases_quantity of
|
Sphingomyelin
|
in the middle frontal gyrus of AD patients, not decreased in the cerebellum
|
|
14970312
|
|
7,848
|
| 78311 |
Alzheimer disease
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in the middle frontal gyrus white matter of AD patients compared to normal subjects
|
|
17888544
|
|
8,037
|
| 79485 |
Amyloid beta peptide (42)
|
|
decreases_quantity of
|
SM C24:0
|
in cultured hippocampal neurons
|
|
14970312
|
|
8,197
|
| 82454 |
aging
|
|
decreases_quantity of
|
Sphingomyelin
|
and in AD brain
|
| 82711 |
Sphingomyelin
|
|
increases_activity of
|
CHRNA7
|
|
| 82717 |
Alzheimer disease
|
|
increases_processing of
|
Sphingomyelin
|
early in AD, excessive SMase-mediated
|
| 82734 |
Sphingomyelin
|
|
increases_activity of
|
NMDA receptor complex
|
|
| 82735 |
Sphingomyelin
|
|
increases_activity of
|
NTRK2
|
|
| 82736 |
Sphingomyelin
|
|
increases_activity of
|
HTR1A
|
|
| 82737 |
Sphingomyelin
|
|
increases_activity of
|
PLAUR
|
|
|
22737128
|
|
8,658
|
| 90024 |
Alzheimer disease
|
|
decreases_quantity of
|
Sphingomyelin
|
in frontal cortex; together with low levels of estrogen in menopause, in Alzheimer’s disease at late stages (ADV-VI)
|
| 90053 |
double-transgenic APP/presenilin mouse
|
|
increases_quantity of
|
Sphingomyelin
|
in aged (14 months old) mice, in neocortex; highly significant
|
|
29559883
|
|
10,849
|
| 111007 |
Alzheimer disease
|
|
affects_quantity of
|
Sphingomyelin
|
it is unclear whether these changes in lipid metabolism are a cause or an effect of AD
|
|
30804776
|
|
11,172
|
| 112931 |
APOE (isoform E4)
|
|
increases_quantity of
|
Sphingomyelin
|
relative to APOE3/APOE3; linked with increased AD risk among males over the age of 55
|
| 112932 |
Sphingomyelin
|
|
increases_activity of
|
Alzheimer disease
|
in males; SM is linked with increased AD risk among males over the age of 55
|
|
31640095
|
|
15,758
|
| 149696 |
Alzheimer disease
|
|
decreases_quantity of
|
Sphingomyelin
|
|
|
|
AlzNet-DB