|
908
|
| 5418 |
Reactive oxygen species
|
|
increases_activity of
|
Alzheimer disease
|
|
| 5419 |
Amyloid beta peptide
|
|
increases_quantity of
|
Reactive oxygen species
|
in neuron; through an NMDA receptor-dependent process
|
| 5421 |
Reactive oxygen species
|
|
increases_activity of
|
abnormal mitochondrial physiology
|
in astrocytes
|
| 5423 |
Reactive oxygen species
|
|
increases_activity of
|
inflammatory response
|
in astrocytes; if ROS production is Abeta-induced
|
| 5430 |
Reactive oxygen species
|
|
increases_activity of
|
cytokine production
|
in astrocytes; if ROS production is Abeta-induced
|
| 5432 |
Reactive oxygen species
|
|
increases_activity of
|
nitric oxide production involved in inflammatory response
|
in astrocytes; if ROS production is Abeta-induced
|
| 5435 |
Reactive oxygen species
|
|
increases_activity of
|
icosanoid metabolic process
|
in astrocytes; if ROS production is Abeta-induced
|
| 5441 |
Reactive oxygen species
|
|
increases_activity of
|
neuron death
|
in astrocytes; if ROS production is Abeta-induced
|
| 10999 |
Reactive oxygen species
|
|
increases_activity of
|
Parkinson disease
|
|
|
19191039
|
|
999
|
| 6204 |
amyloid beta deposits
|
|
increases_quantity of
|
Reactive oxygen species
|
|
|
17086105
|
|
1,068
|
| 6840 |
CDK5
|
|
affects_quantity of
|
Reactive oxygen species
|
depending of glutamate stimulation
|
| 6841 |
Glutamate
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 6843 |
Amyloid beta peptide (25-35)
|
|
increases_quantity of
|
Reactive oxygen species
|
2.5-fold increase in ROS levels, Cdk5-dependent
|
|
18691386
|
|
1,107
|
| 7574 |
Curcumin
|
|
decreases_activity of
|
Reactive oxygen species
|
|
|
20462385
|
|
1,184
|
| 7859 |
Amyloid beta peptide (fibrillar)
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 7860 |
NADPH oxidase complex
|
|
increases_quantity of
|
Reactive oxygen species
|
in microglia; via amyloid beta peptide
|
| 8347 |
NADPH oxidase complex
|
|
affects_quantity of
|
Reactive oxygen species
|
if ROS production is Abeta-induced
|
|
17094809
|
|
1,309
|
| 8998 |
Ibuprofen
|
|
decreases_quantity of
|
Reactive oxygen species
|
in primary microglia; if ROS-production is stimulated by fibrillar amyloid beta peptides
|
|
20696495
|
|
1,377
|
| 9527 |
Reactive oxygen species
|
|
increases_quantity of
|
Amyloid beta peptide (phenoxy radical Tyr-10)
|
|
| 9773 |
response to hypoxia
|
|
increases_quantity of
|
Reactive oxygen species
|
via the mitochondrial transport chain, specifically by the function of complex III
|
|
20552043
|
|
1,566
|
| 11205 |
microglial cell activation
|
|
increases_activity of
|
Reactive oxygen species
|
|
| 11206 |
NADPH oxidase complex
|
|
increases_quantity of
|
Reactive oxygen species
|
|
|
19090996
|
|
1,576
|
| 11353 |
Reactive oxygen species
|
|
increases_expression of
|
BACE1
|
if ROS is overexpressed
|
| 11354 |
Reactive oxygen species
|
|
increases_expression of
|
PSEN1
|
if ROS is overexpressed; mediated through the activation of the JNK pathway;
|
|
20442493
|
|
1,588
|
| 11456 |
innate immune response
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 11658 |
microglial cell activation
|
|
increases_quantity of
|
Reactive oxygen species
|
Activated microglia can produce and release ROS.
|
| 11681 |
Reactive oxygen species
|
|
increases_activity of
|
cellular response to DNA damage stimulus
|
in mitochondria; ROS can cause damage to essential components of the mitochondria such as mitochondrial DNA.
|
| 11683 |
Reactive oxygen species
|
|
decreases_activity of
|
mitochondrion
|
ROS can cause damage to essential components of the mitochondria such as mitochondrial DNA.
|
|
20463396
|
|
1,608
|
| 11833 |
mitochondrion
|
|
increases_quantity of
|
Reactive oxygen species
|
in mitochondria from AD platelets
|
|
20463408
|
|
1,646
|
| 12108 |
Amyloid beta peptide
|
|
increases_quantity of
|
Reactive oxygen species
|
|
|
17088888
|
|
1,667
|
| 12293 |
Alzheimer disease
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 12296 |
Mitochondrial respiratory chain complex IV
|
|
affects_quantity of
|
Reactive oxygen species
|
|
|
14675736
|
|
1,862
|
| 14087 |
APP
|
|
increases_quantity of
|
Reactive oxygen species
|
if APP is overexpressed
|
|
19050078
|
|
1,884
|
| 14315 |
aging
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 14318 |
Reactive oxygen species
|
|
affects_activity of
|
immune system process
|
|
|
18692159
|
|
1,957
|
| 15183 |
Reactive oxygen species
|
|
increases_activity of
|
response to oxidative stress
|
|
| 15197 |
tricarboxylic acid cycle
|
|
increases_quantity of
|
Reactive oxygen species
|
in mitochondria; originating from multiple reactions in the tricarboxylic acid (TCA) cycle and/or the respiratory chain
|
| 15202 |
respiratory electron transport chain
|
|
increases_quantity of
|
Reactive oxygen species
|
in mitochondria; originating from multiple reactions in the tricarboxylic acid (TCA) cycle and/or the respiratory chain
|
| 15236 |
altered metabolic process
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 15323 |
decreased DLST level
|
|
increases_quantity of
|
Reactive oxygen species
|
concerning H2O2-induced increase in ROS and cell death
|
| 15325 |
H2O2
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 15327 |
Reactive oxygen species
|
|
increases_activity of
|
neuron death
|
|
|
19076444
|
|
1,994
|
| 15744 |
SAD cybrid cell
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 15759 |
Puerarin
|
|
decreases_activity of
|
Reactive oxygen species
|
|
|
20933077
|
|
2,192
|
| 18341 |
Olmesartan
|
|
decreases_quantity of
|
Reactive oxygen species
|
in brain microvessels; (Olmesartan is an antihypertensive drug)
|
|
19805638
|
|
3,012
|
| 27478 |
MAPT-proc (1-421)
|
|
increases_quantity of
|
Reactive oxygen species
|
in cortical neurons in mitochondria; with TAU truncated at Asp-421
|
|
19389700
|
|
3,761
|
| 37299 |
Amyloid beta peptide (oligomer)
|
|
increases_quantity of
|
Reactive oxygen species
|
in neurons; through an NMDA (N-methyl-d-aspartate)-dependent pathway
|
| 37317 |
microglia
|
|
increases_quantity of
|
Reactive oxygen species
|
extracellular ROS is toxic to neurons
|
| 37321 |
Reactive oxygen species
|
|
increases_activity of
|
neuroinflammation
|
via extracellular ROS produced by microglia
|
| 37323 |
Reactive oxygen species
|
|
increases_quantity of
|
Proinflammatory cytokine
|
in microglia; such as TNF-alpha, prostaglandin E2, and IL-1beta
|
| 37326 |
Reactive oxygen species
|
|
increases_quantity of
|
TNF
|
in microglia
|
| 37328 |
Reactive oxygen species
|
|
increases_quantity of
|
Prostaglandin E2
|
in microglia
|
| 37330 |
Reactive oxygen species
|
|
increases_quantity of
|
IL1B
|
in microglia
|
| 48849 |
Reactive oxygen species
|
|
increases_activity of
|
inflammatory response
|
intracellular ROS function as a signaling mechanism in microglia
|
|
22970774
|
|
3,768
|
| 36747 |
CD14
|
|
affects_quantity of
|
Reactive oxygen species
|
stimulated by fAbeta
|
| 36748 |
TLR4
|
|
affects_quantity of
|
Reactive oxygen species
|
stimulated by fAbeta
|
| 36749 |
TLR2
|
|
affects_quantity of
|
Reactive oxygen species
|
stimulated by fAbeta
|
| 36750 |
p38 MAPK
|
|
affects_quantity of
|
Reactive oxygen species
|
|
|
19776284
|
|
3,792
|
| 37646 |
Advanced glycation end-product
|
|
increases_quantity of
|
Reactive oxygen species
|
in both microglial (CHME-5) and astroglial cells (U373MG)
|
|
19464758
|
|
6,540
|
| 63213 |
Amyloid beta peptide
|
|
increases_quantity of
|
Reactive oxygen species
|
intracellular; resulting in increased intracellular ROS accumulation
|
|
26515689
|
|
8,979
|
| 94330 |
4-Hydroxynonenal
|
|
increases_quantity of
|
Reactive oxygen species
|
in mitochondria; and caused concentration-dependent decreases in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, and reduced cellular ATP levels significantly
|
| 94338 |
Amyloid beta peptide
|
|
increases_quantity of
|
Reactive oxygen species
|
in mitochondria; and caused concentration-dependent decreases in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, and reduced cellular ATP levels significantly
|
| 94340 |
FeSO4
|
|
increases_quantity of
|
Reactive oxygen species
|
in mitochondria; and caused concentration-dependent decreases in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, and reduced cellular ATP levels significantly
|
|
9202320
|
|
8,986
|
| 93790 |
Reactive oxygen species
|
|
increases_activity of
|
abnormal mitochondrial physiology
|
|
| 94126 |
increased glycolytic flux
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 94127 |
decreased mitochondrial pyruvate uptake
|
|
decreases_quantity of
|
Reactive oxygen species
|
|
| 94136 |
NADPH depletion
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 94153 |
increased NADH/NAD+ ratio
|
|
increases_quantity of
|
Reactive oxygen species
|
|
|
26047665
|
|
10,849
|
| 111021 |
Reactive oxygen species
|
|
increases_activity of
|
lipid peroxidation
|
in neurons ; elevated ROS induces lipid peroxidation, triggering subsequent efflux of lipids that accumulate as lipid droplets in neighboring astrocytes
|
|
30804776
|
|
11,294
|
| 113456 |
increased sterol level
|
|
increases_quantity of
|
Reactive oxygen species
|
oxidizing ACAT2 at the Cys277 (C277) residue, stabilizing the protein by competitively blocking its ubiquitylation and proteasomal degradation and thereby promoting cholesterol storage and/or export
|
| 113494 |
increased fatty acid level
|
|
increases_quantity of
|
Reactive oxygen species
|
oxidizing ACAT2 at the Cys277 (C277) residue, stabilizing the protein by competitively blocking its ubiquitylation and proteasomal degradation and thereby promoting cholesterol storage and/or export
|
| 113495 |
Reactive oxygen species
|
|
increases_activity of
|
SOAT1
|
via oxidizing ACAT2 at the Cys277 (C277) residue, stabilizing the protein by competitively blocking its ubiquitylation and proteasomal degradation and thereby promoting cholesterol storage and/or export
|
|
31848472
|
|
11,419
|
| 114184 |
APOE (isoform E4)
|
|
increases_quantity of
|
Reactive oxygen species
|
in apoE4 cells
|
|
30883359
|
|
11,492
|
| 114817 |
Amyloid beta peptide (oligomer)
|
|
increases_quantity of
|
Reactive oxygen species
|
|
|
18478527
|
|
11,639
|
| 115822 |
sex, female
|
|
decreases_quantity of
|
Reactive oxygen species
|
in cardiomyocytes from female rats; compared to males
|
| 115823 |
female brain mitochondria
|
|
decreases_quantity of
|
Reactive oxygen species
|
in female brains; with higher capacity of antioxidant defenses, compared to males
|
| 115851 |
female liver mitochondria
|
|
decreases_quantity of
|
Reactive oxygen species
|
in female liver; with higher capacity of antioxidant defenses, compared to males
|
| 115852 |
female heart mitochondria
|
|
decreases_quantity of
|
Reactive oxygen species
|
in female heart; with higher capacity of antioxidant defenses, compared to males
|
| 153290 |
O2-
|
|
increases_quantity of
|
Reactive oxygen species
|
by-product of electron transport, essentially at complex I and III of the respiratory chain
|
| 153291 |
H2O2
|
|
increases_quantity of
|
Reactive oxygen species
|
by-product of electron transport, essentially at complex I and III of the respiratory chain
|
| 153292 |
Hydroxyl radical
|
|
increases_quantity of
|
Reactive oxygen species
|
by-product of electron transport, essentially at complex I and III of the respiratory chain
|
| 153293 |
Mitochondrial respiratory chain complex I
|
|
increases_quantity of
|
Reactive oxygen species
|
by-product of electron transport, essentially at complex I and III of the respiratory chain
|
| 153294 |
Mitochondrial respiratory chain complex III
|
|
increases_quantity of
|
Reactive oxygen species
|
by-product of electron transport, essentially at complex I and III of the respiratory chain
|
|
28424375
|
AlzNet-DB