| 77788 |
N-Acylsphingosine
|
|
increases_activity of
|
sphingomyelin biosynthetic process
|
|
| 80768 |
N-Acylsphingosine
|
|
increases_quantity of
|
Sphingosine
|
via deacylation of ceramide
|
| 80770 |
N-Acylsphingosine
|
|
increases_quantity of
|
Sphingomyelin
|
|
| 80771 |
N-Acylsphingosine
|
|
increases_activity of
|
glycosphingolipid biosynthetic process
|
via addition of one or more sugar residues, joined with a alpha-glycosidic linkage at the 1-hydroxyl position
|
| 80800 |
Dihydroceramide desaturase
|
|
increases_quantity of
|
N-Acylsphingosine
|
ceramide de novo synthesis
|
| 80863 |
sphingomyelin catabolic process
|
|
increases_quantity of
|
N-Acylsphingosine
|
via catabolism of sphingomyelin via a family of sphingomyelinases
|
| 80866 |
Sphingomyelinase
|
|
increases_quantity of
|
N-Acylsphingosine
|
catabolism of sphingomyelin, via hydrolyzing the phosphodiester bond of sphingomyelin
|
| 80884 |
Glycerophosphocholine
|
|
decreases_quantity of
|
N-Acylsphingosine
|
via transferring a phosphocholine head group from phosphatidylcholine (Glycerophosphocholine) onto ceramide by the enzyme phosphatidylcholine transferase (sphingomyelin synthase)
|
| 80889 |
Phosphatidylcholine
|
|
decreases_quantity of
|
N-Acylsphingosine
|
via transferring a phosphocholine head group from phosphatidylcholine (Glycerophosphocholine) onto ceramide by the enzyme phosphatidylcholine transferase (sphingomyelin synthase)
|
| 80912 |
Sphingomyelin synthase
|
|
decreases_quantity of
|
N-Acylsphingosine
|
|
| 80922 |
Ceramidase
|
|
decreases_quantity of
|
N-Acylsphingosine
|
|
| 81218 |
N-Acylsphingosine
|
|
is localized in
|
membrane raft
|
Ceramide is a major bioactive component of lipid rafts.
|
| 81331 |
sphingolipid metabolic process
|
|
affects_quantity of
|
N-Acylsphingosine
|
|
| 81345 |
N-Acylsphingosine
|
|
is localized in
|
membrane raft
|
in neuron
|
| 81547 |
TNF
|
|
increases_quantity of
|
N-Acylsphingosine
|
|
| 81548 |
response to oxidative stress
|
|
increases_quantity of
|
N-Acylsphingosine
|
|
| 81549 |
N-Acylsphingosine
|
|
increases_activity of
|
pro-apoptotic pathway
|
if there is a sustained or excessive increase of ceramide
|
| 81552 |
IL1
|
|
increases_quantity of
|
N-Acylsphingosine
|
|
| 81553 |
FAS
|
|
increases_quantity of
|
N-Acylsphingosine
|
Fas/FasL are potent inducers of ceramide production
|
| 81554 |
FASLG
|
|
increases_quantity of
|
N-Acylsphingosine
|
Fas/FasL are potent inducers of ceramide production
|
| 81555 |
N-Acylsphingosine
|
|
increases_quantity of
|
IL2
|
if concentration of ceramide is increased
|
| 81556 |
N-Acylsphingosine
|
|
increases_quantity of
|
IL6
|
if concentration of ceramide is increased
|
| 81557 |
Acetylcysteine
|
|
decreases_quantity of
|
N-Acylsphingosine
|
if induced by TNFalpha and Fas-ligand
|
| 81558 |
Pyrrolidine dithiocarbamate
|
|
decreases_quantity of
|
N-Acylsphingosine
|
if induced by TNFalpha and Fas-ligand
|
| 81559 |
Glutathione
|
|
decreases_quantity of
|
N-Acylsphingosine
|
if induced by TNFalpha and Fas-ligand
|
| 81560 |
alpha-Tocopherol
|
|
decreases_quantity of
|
N-Acylsphingosine
|
if induced by TNFalpha and Fas-ligand
|
| 81561 |
Fas signaling pathway
|
|
increases_quantity of
|
N-Acylsphingosine
|
Fas/FasL are potent inducers of ceramide production
|
| 81564 |
Sphingomyelinase
|
|
increases_quantity of
|
N-Acylsphingosine
|
if there is a caspase8-dependent increase in SMase activity
|
AlzNet-DB