|
487
|
| 2303 |
Glucose
|
|
affects_activity of
|
learning or memory
|
|
|
15094077
|
|
569
|
| 2966 |
Glucose
|
|
affects_quantity of
|
APP
|
in plasma
|
| 2969 |
Glucose
|
|
increases_quantity of
|
Insulin
|
|
|
10670439
|
|
6,481
|
| 62247 |
Glucose
|
|
affects_quantity of
|
Insulin
|
|
|
25998028
|
|
7,815
|
| 77897 |
Glucose
|
NOT |
affects_quantity of
|
Ceramide
|
in CSF
|
| 77898 |
Glucose
|
NOT |
affects_quantity of
|
Sphingomyelin
|
in CSF
|
|
24952994
|
|
8,985
|
| 94082 |
Proline
|
|
decreases_quantity of
|
Glucose
|
in rats; when proline level is increased; through inhibition of liver glucose production secondary to an inhibition of hepatic glycogenolysis and gluconeogenesis
|
| 94087 |
Pyruvate
|
|
affects_quantity of
|
Glucose
|
in liver; via mediobasal hypothalamus lactate-pyruvate regulation
|
| 94108 |
Glucose
|
|
affects_activity of
|
glucose metabolic process
|
LDH-dependent hypothalamic modulator of glucose metabolism
|
| 94209 |
glycogen catabolic process
|
|
increases_quantity of
|
Glucose
|
|
| 94210 |
gluconeogenesis
|
|
increases_quantity of
|
Glucose
|
|
|
23274895
|
|
9,087
|
| 95683 |
Glucose
|
|
is localized in
|
neuron
|
|
| 95730 |
Glucose
|
|
is localized in
|
astrocyte
|
|
| 95731 |
Glucose
|
|
increases_quantity of
|
Acetyl-CoA
|
in neurons
|
|
23340677
|
|
9,095
|
| 126140 |
SLC2A4
|
|
increases_transport of
|
Glucose
|
across cell membrane; stored in vesicles in the cytoplasm of cells
|
|
26402005
|
|
9,101
|
| 95445 |
HK1
|
|
decreases_quantity of
|
Glucose
|
via conversion of glucose to glucose-6-phosphat
|
| 95466 |
HK2
|
|
decreases_quantity of
|
Glucose
|
via conversion of glucose to glucose-6-phosphat
|
|
29967007
|
|
10,915
|
| 111217 |
aerobic glycolysis
|
|
decreases_quantity of
|
Glucose
|
in cancer cells, but also in non-cancerous cells; aerobic glycolysis is the preferential conversion of glucose to lactate, even in the presence of oxygen
|
|
30804776
|
|
13,416
|
| 126461 |
Glucose
|
|
increases_activity of
|
increased rate of ATP generation
|
in neurons; compared to adipose tissue-derived fatty acids as fuel, in periods of extended continuous and rapid neuronal firing
|
| 126494 |
Glucose
|
|
increases_quantity of
|
ATP
|
|
|
23921897
|
|
13,764
|
| 129527 |
SLC2A3
|
|
increases_transport of
|
Glucose
|
in neuron cells; where glucose is phosphorylated by hexokinase to G6P
|
| 129533 |
Glucose
|
|
increases_quantity of
|
Glucose 6-phosphate
|
in neuron cells; via phosphorylating glucose by hexokinase to G6P
|
| 129535 |
HK
|
|
decreases_quantity of
|
Glucose
|
in neuron cells; via phosphorylating glucose by hexokinase to G6P
|
| 129566 |
astrocyte
|
|
increases_transport of
|
Glucose
|
via GLUT1
|
| 129580 |
SLC2A1
|
|
increases_transport of
|
Glucose
|
into astrocytes
|
|
28438892
|
|
13,848
|
| 130184 |
hypoglycemia
|
|
increases_transport of
|
Glucose
|
across BBB; concerning chronic hypoglycemia, resulting from a concomitant increase in GLUT-1 transcription and expression on lumenal side of brain capillaries
|
| 130189 |
SLC2A1
|
|
increases_transport of
|
Glucose
|
to CNS
|
| 130200 |
SLC5A1
|
|
increases_transport of
|
Glucose
|
sodium-dependent glucose transporter (2Na+/Glucose)
|
|
24708805
|
|
13,856
|
| 130293 |
tight junction
|
NOT |
affects transport of
|
Glucose
|
the hydrophilic compound D-glucose cannot transverse tight junctions
|
| 130294 |
SLC2A1
|
|
increases_transport of
|
Glucose
|
across the BBB
|
| 130298 |
SLC2A3
|
|
increases_transport of
|
Glucose
|
into neurons
|
| 130301 |
Glucose
|
|
increases_activity of
|
canonical glycolysis
|
in neurons; further metabolized by oxidative phosphorylation
|
| 130304 |
transport across blood-brain barrier
|
|
increases_quantity of
|
Glucose
|
in brain interstitium or brain ventricles; via passing BBB between choroid plexus and CSF in brain ventricles (=the barrier between brain interstitium and brain ventricles), or passing BBB between CVOs and brain ventricles
|
| 130446 |
Glucose
|
|
is localized in
|
neuron
|
in brain ; via GLUT3/SLC2A3 glucose transporter
|
| 130504 |
SLC2A4
|
|
increases_transport of
|
Glucose
|
|
|
32789766
|
|
13,861
|
| 130549 |
Glucose
|
|
increases_activity of
|
canonical glycolysis
|
concerning intracellular glucose
|
| 130550 |
Glucose
|
|
increases_activity of
|
mitochondrion
|
concerning intracellular glucose
|
| 130592 |
SLC2A6
|
|
increases_transport of
|
Glucose
|
|
| 130606 |
SLC2A8
|
|
increases_transport of
|
Glucose
|
|
|
32789766
|
|
13,862
|
| 131363 |
GCK
|
|
increases_phosphorylation of
|
Glucose
|
followed by oxidative phosphorylation and blockage of an octameric ATP-sensitive K+channel
|
| 131364 |
GCK
|
|
decreases_quantity of
|
Glucose
|
via phosphorylation of glucose
|
| 131424 |
Glucose
|
|
decreases_activity of
|
ATP-sensitive potassium channel complex
|
via blockage of an octameric ATP-sensitive K+channel, resulting in a depolarization of the plasma membrane
|
| 131436 |
Glucose
|
|
interacts (colocalizes) with
|
TAS1R2-TAS1R3 complex
|
activation of intracellular signal cascades that finally increase neuronal activity
|
| 131437 |
SLC5A1
|
|
increases_transport of
|
Glucose
|
in human; sensing low D-glucose concentrations
|
| 131438 |
SLC5A4
|
|
increases_transport of
|
Glucose
|
in human; sensing high D-glucose concentrations
|
| 131456 |
glucose concentration gradient
|
|
increases_transport of
|
Glucose
|
between blood and brain interstitium across capillary endothelial cells into astrocytes
|
| 131489 |
epileptic seizures
|
|
increases_transport of
|
Glucose
|
across the BBB
|
| 131494 |
neuronal activation
|
|
increases_transport of
|
Glucose
|
into astrocytes; GLUT1 mediated
|
| 131496 |
neuronal activation
|
NOT |
affects transport of
|
Glucose
|
into neurons; mainly mediated by uptake of released glutamate via the Na+ -glutamate cotransporter that leads to an increase of intracellular Na+ which triggers increase of intracellular Ca2+
|
| 139383 |
glucose import
|
|
increases_transport of
|
Glucose
|
from blood into brain
|
| 139384 |
glucose import
|
|
increases_quantity of
|
Glucose
|
in brain
|
|
32789766
|
|
13,968
|
| 132006 |
neuron
|
NOT |
affects_quantity of
|
Glucose
|
brain neurons are unable to synthesize or store glucose
|
| 132015 |
transport across blood-brain barrier
|
|
increases_quantity of
|
Glucose
|
in brain neurons
|
|
18174027
|
|
14,058
|
| 132840 |
aging
|
|
decreases transport of
|
Glucose
|
in both nonTg and 3xTgAD female brain; between 6-9 months of age just prior to the transition into reproductive senescence
|
| 132859 |
reproductive senescence
|
|
decreases transport of
|
Glucose
|
in both nonTg and 3xTgAD female brain
|
|
24244584
|
AlzNet-DB