|
3,792
|
| 38231 |
Estrogen
|
|
decreases_activity of
|
Alzheimer disease
|
probabely only effective in very early stages of the disease
|
|
19464758
|
|
7,322
|
| 71998 |
Estrogen
|
|
increases_activity of
|
negative regulation of neuron death
|
|
| 72002 |
Estrogen
|
|
decreases_activity of
|
abnormal mitochondrial physiology
|
estrogen has neuroprotective effects
|
| 72062 |
Estrogen
|
|
increases_activity of
|
hippocampus
|
in the CA1 region
|
| 72063 |
Estrogen
|
|
increases_quantity of
|
ESR1
|
in the CA1 region of the hippocampus
|
| 85050 |
oophorectomy
|
|
decreases_quantity of
|
Estrogen
|
if bilateral and prior to menopause
|
| 115232 |
Estrogen
|
|
increases_activity of
|
synapse formation
|
on hippocampal dendritic spines; estrogen has neuroprotective effects
|
| 115233 |
Estrogen
|
|
increases_activity of
|
maintaining hippocampal function during aging
|
estrogen has neuroprotective effects
|
| 115234 |
Estrogen
|
|
increases_activity of
|
increased brain blood flow rate
|
estrogen has neuroprotective effects
|
| 115235 |
Estrogen
|
|
increases_activity of
|
glucose metabolic process
|
estrogen has neuroprotective effects
|
| 115236 |
Estrogen
|
|
increases_activity of
|
CHAT
|
in the basal forebrain and hippocampus; estrogen has neuroprotective effects
|
| 115237 |
Estrogen
|
|
decreases_quantity of
|
amyloid beta deposits
|
and associated neurotoxicity; estrogen has neuroprotective effects
|
| 115238 |
Estrogen
|
|
decreases_activity of
|
neuron death
|
via reducing amyloid-beta aggregations; estrogen has neuroprotective effects
|
|
24470773
|
|
7,871
|
| 79139 |
Estrogen
|
|
decreases_activity of
|
Alzheimer disease
|
|
|
26708713
|
|
8,023
|
| 79409 |
Estrogen
|
|
decreases_activity of
|
MAPT-hyperphos
|
in mutant tau cells
|
| 79411 |
Estrogen
|
|
decreases_activity of
|
Tauopathy
|
in mutant tau cells
|
|
26198711
|
|
8,158
|
| 95979 |
Estrogen
|
|
increases_phosphorylation of
|
VDAC1
|
through binding to mERalpha
|
| 95984 |
Estrogen
|
|
increases_activity of
|
channel phosphorylation
|
in neuronal cultures; when estrogen is bound to mERalpha/ESR1,
through rapid activation of PKA and Src-kinase signal transduction pathways
|
| 96015 |
Estrogen
|
|
decreases_activity of
|
VDAC1
|
through binding to mERalpha and via phosphorylation of VDAC1
|
| 96016 |
Estrogen
|
|
interacts (colocalizes) with
|
ESR1
|
hereby enhancing plasma membrane VDAC1 phosphorylation and inactivation
|
|
27814578
|
|
8,575
|
| 88291 |
Estrogen
|
|
increases_activity of
|
negative regulation of neuron death
|
|
| 88298 |
Estrogen
|
|
increases_expression of
|
DHCR24
|
|
|
15954227
|
|
8,658
|
| 89839 |
Estrogen
|
|
increases_activity of
|
brain lipid matrix stability
|
together with docosahexaenoic acid (DHA)via synergistic effects
|
| 90169 |
Estrogen
|
|
is localized in
|
hippocampus
|
via local production
|
|
29559883
|
|
8,991
|
| 94396 |
Estrogen
|
|
affects_expression of
|
IDE
|
in normal, menopausal and early-stage AD brains.
|
|
20053478
|
|
11,639
|
| 115867 |
Estrogen
|
|
increases_activity of
|
female heart mitochondria
|
in female heart mitochondria; estrogens protect heart mitochondria from high calcium-induced release of cytochrome c
|
| 115868 |
Estrogen
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
in female heart mitochondria; estrogens protect heart mitochondria from high calcium-induced release of cytochrome c
|
|
28424375
|
|
12,066
|
| 118527 |
Estrogen
|
|
increases_activity of
|
electron transport chain
|
|
| 118531 |
Estrogen
|
|
increases_activity of
|
positive regulation of mitochondrial membrane potential
|
stabilizing the MMP
|
| 118532 |
Estrogen
|
|
decreases_quantity of
|
Reactive oxygen species
|
Estrogen has been shown to prevent the ROS production
|
| 118533 |
Estrogen
|
|
increases_activity of
|
basal respiration
|
Estrogen has been shown to ameliorate the basal respiration
|
| 118537 |
Estrogen
|
|
increases_quantity of
|
ATP
|
Estrogen has been shown to ameliorate the ATP production
|
|
29755342
|
|
12,556
|
| 122271 |
Estrogen
|
NOT |
affects_activity of
|
Alzheimer disease
|
in most studies
|
| 122305 |
Estrogen
|
NOT |
affects_activity of
|
Alzheimer disease
|
in most studies; estrogen treatment was unable to slow the progression of AD
|
| 122306 |
Estrogen
|
NOT |
affects_activity of
|
cognition
|
in elderly women with APOE4 allele; estrogen had no beneficial effect on cognitive function
|
| 122314 |
Estrogen
|
|
decreases_activity of
|
Alzheimer disease
|
some studies suggested that estrogen may delay or prevent the onset of AD
|
|
12077215
|
|
12,827
|
| 123198 |
Estrogen
|
|
decreases_activity of
|
cognitive impairment
|
in ApoE4-negative women; concerning current estrogen use, compared with never users
|
| 123211 |
Estrogen
|
NOT |
affects_activity of
|
cognitive impairment
|
in ApoE4-positive females / women
|
|
17077142
|
|
12,840
|
| 123234 |
Estrogen
|
|
decreases_activity of
|
cognitive impairment
|
in APOE4-negative women; compared with never users, but not in APOE4-positive women
|
| 123238 |
Estrogen
|
NOT |
affects_activity of
|
cognitive impairment
|
in APOE4-positive women; compared with never users
|
| 123241 |
Estrogen
|
|
decreases_activity of
|
carotid artery wall thickening
|
in APOE4-negative women; but not in APOE4-positive women
|
|
10822435
|
|
13,024
|
| 124146 |
CYP19A1
|
|
increases_quantity of
|
Estrogen
|
influencing the final step in the biosynthesis of estrogen
|
|
27583919
|
|
13,714
|
| 128877 |
Testosterone
|
|
increases_quantity of
|
Estrogen
|
in women; estrogen is made from testosterone and other adrenal hormones
|
|
28655134
|
|
13,729
|
| 129261 |
Estrogen
|
|
decreases_activity of
|
BACE1
|
in female APP23 mice with a genetic deficiency of aromatase, in which the brain contains non-detectable levels of estrogen (APP/Ar+/‚Äď); administration of estrogen, but not testosterone, may prevent the Abeta production by inhibiting BACE1 activity
|
|
28655134
|
|
13,811
|
| 129823 |
Estrogen
|
|
affects_activity of
|
regulation of vascular tone
|
the actions of estrogens and androgens often oppose each other
|
| 129825 |
Estrogen
|
|
affects_activity of
|
angiogenesis
|
the actions of estrogens and androgens often oppose each other
|
| 129827 |
Estrogen
|
|
affects_activity of
|
endothelial cell survival
|
the actions of estrogens and androgens often oppose each other
|
| 129829 |
Estrogen
|
|
affects_activity of
|
response to oxidative stress
|
the actions of estrogens and androgens often oppose each other
|
| 129831 |
Estrogen
|
|
affects_activity of
|
inflammatory response
|
in cerebral blood vessels; the actions of estrogens and androgens often oppose each other
|
|
|
|
14,021
|
| 132509 |
Estrogen
|
|
affects_activity of
|
glucose metabolic process
|
|
| 132626 |
Estrogen
|
|
decreases_activity of
|
Alzheimer disease
|
in AD brain; by reducing beta-amyloid production and enhancing its clearance, protecting against apoptosis, supporting neuronal function and signaling
|
|
25921624
|
|
14,221
|
| 134249 |
Estrogen
|
|
interacts (colocalizes) with
|
GSK3B
|
lowering its activity and resulting in decreased hyperphosphorylation of tau
|
|
30394676
|
|
14,876
|
| 139564 |
Estrogen
|
NOT |
affects_activity of
|
cognitive function
|
in older women
|
|
10573435
|
AlzNet-DB