|
2,976
|
| 27105 |
young coconut juice supplementation
|
|
increases_quantity of
|
Estradiol
|
|
|
21114897
|
|
3,792
|
| 37652 |
Estradiol
|
|
decreases_quantity of
|
Glutathione disulfide
|
if increase in oxidized glutathione is AGE-induced
|
|
19464758
|
|
4,560
|
| 45480 |
Estradiol
|
|
increases_phosphorylation of
|
GSK3B
|
|
| 45484 |
Estradiol
|
|
increases_quantity of
|
CTNNB1
|
(a modest increase)
|
| 45488 |
Estradiol
|
|
affects_activity of
|
GSK3B
|
in the adult female rat hippocampus; a transient activation, followed by an inhibition
|
| 45490 |
Estradiol
|
|
increases_quantity of
|
CTNNB1-GSK3B-MAPT-PIK3R complex
|
|
| 85063 |
Estradiol
|
|
decreases_activity of
|
GSK3B
|
in the adult female rat hippocampus; after a transient activation
|
| 85064 |
Estradiol
|
|
decreases_activity of
|
GSK3A
|
in the adult female rat hippocampus; after a transient activation
|
| 85065 |
Estradiol
|
|
increases_phosphorylation of
|
GSK3A
|
in the adult female rat hippocampus
|
| 151346 |
Estradiol
|
|
affects_activity of
|
GSK3A
|
in the adult female rat hippocampus; a transient activation, followed by an inhibition
|
| 151350 |
Estradiol
|
|
increases_phosphorylation of
|
MAPT
|
in primary hippocampal neurons of female rats
|
|
15033165
|
|
7,322
|
| 71997 |
menopause
|
|
decreases_quantity of
|
Estradiol
|
|
|
24470773
|
|
7,454
|
| 73378 |
Estradiol
|
|
increases_activity of
|
Alzheimer disease
|
in carriers of apolipoprotein E4 (ApoE4)
|
| 73381 |
Estradiol
|
|
decreases_activity of
|
Alzheimer disease
|
in carriers of apolipoprotein E2/3 (ApoE2 and ApoE3)
|
|
17077142
|
|
7,459
|
| 73444 |
APOD
|
|
interacts (colocalizes) with
|
Estradiol
|
|
|
21423873
|
|
7,461
|
| 73430 |
Estradiol
|
|
increases_activity of
|
mossy fiber sprouting
|
in dentate gyrus
|
| 73432 |
APOE-null
|
|
decreases_activity of
|
Estradiol
|
in dentate gyrus
|
| 73435 |
Estradiol
|
|
increases_expression of
|
CLU
|
; in EC-lesioned WT mice
|
|
9547226
|
|
7,868
|
| 102069 |
APOE (isoform E4)
|
|
affects_activity of
|
Estradiol
|
in ovariectomized EFAD mice treated with estradiol; extracellular amyloid plaque and Abeta deposition is increased with APOE4
|
| 102072 |
Estradiol
|
|
increases_quantity of
|
Amyloid beta peptide
|
in cortex of E4FAD mice; forming extracellular plaque
|
| 102073 |
APOE
|
|
affects_activity of
|
Estradiol
|
concerning the effect of estrogen therapy on Abeta accumulation in EFAD-Tg mice
|
| 102082 |
APOE (isoform E3)
|
|
affects_activity of
|
Estradiol
|
in ovariectomized EFAD mice treated with estradiol; extracellular amyloid plaque and Abeta deposition is decreased with APOE2 and APOE3
|
| 102083 |
APOE (isoform E2)
|
|
affects_activity of
|
Estradiol
|
in ovariectomized EFAD mice treated with estradiol; extracellular amyloid plaque and Abeta deposition is decreased with APOE2 and APOE3
|
| 102087 |
Estradiol
|
|
increases_quantity of
|
Amyloid beta peptide (42, insoluble)
|
in cortex of E4FAD mice
|
| 102089 |
Estradiol
|
|
increases_quantity of
|
amyloid beta deposits
|
in cortex of E4FAD mice; forming extracellular plaque
|
| 102090 |
Estradiol
|
NOT |
affects_quantity of
|
Amyloid beta peptide (insoluble)
|
in hippocampus of E4FAD mice
|
|
24368217
|
|
8,023
|
| 79407 |
Estradiol
|
|
increases_quantity of
|
ATP
|
in mutant tau cells
|
|
26198711
|
|
8,026
|
| 79350 |
Estradiol
|
|
decreases_quantity of
|
amyloid beta deposits
|
in recently postmenopausal women; Transdermal 17beta-estradiol therapy;
particularly in APOE4 carriers
|
| 84824 |
APOE (isoform E4)
|
|
increases_activity of
|
Estradiol
|
in recently postmenopausal women; concerning Transdermal 17beta-estradiol therapy; particularly in APOE4 carriers
|
|
27163830
|
|
8,158
|
| 81935 |
Estradiol
|
|
interacts (colocalizes) with
|
Estrogen receptor
|
in neuronal membrane; triggering neuroprotective responses by anchoring to scaffolding caveolin-1 complexed with other proteins
|
|
27814578
|
|
8,362
|
| 84822 |
Alzheimer disease
|
|
decreases_quantity of
|
Estradiol
|
in AD cerebrospinal fluid
|
|
11427315
|
|
8,658
|
| 89833 |
menopause
|
|
decreases_quantity of
|
Estradiol
|
at frontal cortical brain areas
|
| 89838 |
Estradiol
|
|
affects_activity of
|
membrane raft
|
|
| 89879 |
Estradiol
|
|
increases_quantity of
|
myelin sheath
|
|
| 89880 |
Estradiol
|
|
increases_activity of
|
amyloid-beta clearance
|
in Alzheimer
|
| 89881 |
Estradiol
|
|
increases_activity of
|
myelination
|
through direct actions in Schwann and oligodendroglial cells
|
| 89889 |
Estradiol
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
in brain areas related to memory and cognition
|
| 89890 |
Estradiol
|
|
increases_activity of
|
Raf/MEK/ERK signaling
|
enhances neuroprotection following ischemic brain injury, stroke and Abeta- and glutamate-induced toxicities
|
| 89894 |
Estradiol
|
|
increases_phosphorylation of
|
VDAC
|
in neurons; preventing VDAC channel dephosphorylationvia binding of E2 to ERa signalosome
|
| 89900 |
Estradiol
|
|
decreases_activity of
|
response to oxidative stress
|
in mitochondria; via acting as regulator of bioenergetics circuits, counteracting
the oxidative stress and glucose hypometabolism
|
| 89901 |
Estradiol
|
|
decreases_activity of
|
decreased glucose level
|
in mitochondria; via acting as regulator of bioenergetics circuits, counteracting
the oxidative stress and glucose hypometabolism
|
| 89904 |
Estradiol
|
|
increases_activity of
|
PI3K/AKT/GSK3 signaling
|
in brain areas related to memory and cognition
|
| 89905 |
Estradiol
|
|
decreases_activity of
|
VDAC channel dephosphorylation
|
in neurons; of VDAC channel via binding of E2 to ERa signalosome
|
| 90172 |
Estradiol
|
|
increases_quantity of
|
Docosahexaenoic acid
|
via converting alpha-linolenic acid (ALA) to DHA; increasing the uptake of DHA into the plasma membrane
|
| 90178 |
docosahexaenoic acid supplementation
|
|
increases_quantity of
|
Estradiol
|
in cerebral cortex
|
| 90182 |
Estradiol
|
|
affects_activity of
|
cholesterol biosynthetic process
|
in hippocampus; via modulation in expression of 3-hydroxy 3-methylglutaryl
coenzyme A reductase (HMG-CoAR) and acetyl-coenzyme A acetyltransferase (ACAT) genes
|
| 90186 |
Estradiol
|
|
increases_activity of
|
DHA uptake
|
in both the maternal and fetal brain; during pregnancy
|
| 93133 |
Estradiol
|
|
increases_activity of
|
PI3K/AKT signaling
|
in brain areas related to memory and cognition
|
| 139516 |
Estradiol
|
|
decreases_activity of
|
glucose hypometabolism
|
in mitochondria; via acting as regulator of bioenergetics circuits, counteracting
the oxidative stress and glucose hypometabolism
|
| 149967 |
Estradiol
|
|
increases_activity of
|
myelinating Schwann cell
|
enhancing the synthesis of myelin basic protein and myelin sheet formation
|
| 149968 |
Estradiol
|
|
increases_activity of
|
oligodendrocyte
|
enhancing the synthesis of myelin basic protein and myelin sheet formation
|
|
29559883
|
|
8,746
|
| 91060 |
Estradiol
|
|
increases_expression of
|
APP695
|
in adult male and female mice after gonadectomy; concerning APP695 mRNA
|
| 91076 |
Estradiol
|
|
decreases_expression of
|
APP695
|
in old female mice after gonadectomy; concerning APP695 mRNA;
|
| 91080 |
Estradiol
|
NOT |
affects_expression of
|
APP695
|
in old male mice after gonadectomy; concerning APP695 mRNA;
|
| 139792 |
Estradiol
|
|
affects_expression of
|
APP (splice variant)
|
in the mice brain cortex; through its effects on alternative splicing, concerning the mRNAs
|
|
15882808
|
|
8,751
|
| 91088 |
Estradiol
|
|
decreases_activity of
|
impaired spatial memory
|
in OVX Sprague-Dawley rats; after ovariectomy
|
|
15357665
|
|
8,904
|
| 92990 |
Estradiol
|
|
interacts (colocalizes) with
|
Estrogen receptor
|
at the neuronal membrane
|
| 93153 |
Estradiol
|
|
increases_phosphorylation of
|
VDAC
|
through the activation of protein kinase A (PKA) and Src-kinase
|
| 93155 |
Estradiol
|
|
increases_activity of
|
G protein-coupled receptor signaling pathway
|
at the neuronal membrane
|
| 93156 |
Estradiol
|
|
increases_activity of
|
Ionotropic receptor
|
at the neuronal membrane
|
|
21354436
|
|
8,991
|
| 94397 |
Estradiol
|
|
increases_expression of
|
IDE
|
in primary cultures of rat hippocampal neurons; in both mRNA and protein levels in a time-dependent manner
|
| 94410 |
Estradiol
|
|
decreases_activity of
|
ovariectomy
|
in the hippocampus; concerning the ovariectomy (OVX) induced significant decline in IDE expression
|
| 94411 |
Estradiol
|
NOT |
affects_expression of
|
IDE
|
in the cerebellum
|
| 136235 |
Estradiol
|
|
increases_quantity of
|
IDE
|
in primary cultures of rat hippocampal neurons; in both mRNA and protein levels in a time-dependent manner
|
|
20053478
|
|
9,026
|
| 94408 |
Estradiol
|
|
decreases_activity of
|
amyloid beta deposits
|
in 3xTg-AD female OVX mice
|
| 94412 |
Estradiol
|
|
decreases_quantity of
|
amyloid beta deposits
|
in 3xTg-AD female OVX mice
|
| 94415 |
Estradiol
|
|
increases_expression of
|
IDE
|
in hippocampus in 12-month-old 3xTg-AD OVX mice
|
|
20053478
|
|
12,556
|
| 122261 |
Testosterone
|
|
increases_quantity of
|
Estradiol
|
|
| 122262 |
Dihydrotestosterone
|
NOT |
affects_quantity of
|
Estradiol
|
|
| 139511 |
Dihydrotestosterone
|
NOT |
affects_quantity of
|
Estradiol
|
|
|
12077215
|
|
12,827
|
| 123170 |
Estradiol
|
|
increases_activity of
|
ESR1
|
in adult female rat hippocampi
|
| 123200 |
Estradiol
|
|
increases_expression of
|
APOE
|
in astrocytes and microglia and in neurons
|
| 123226 |
Estradiol
|
|
increases_activity of
|
ESR2
|
in mouse HT-22 cells; ERbeta is activated by E2
|
|
17077142
|
|
12,865
|
| 123371 |
Estradiol
|
|
increases_activity of
|
ESR1
|
with ERalpha, E2 activated transcription
|
| 123372 |
Estradiol
|
|
increases_activity of
|
mRNA transcription
|
with ERalpha, E2 activated transcription
|
| 123373 |
Estradiol
|
|
decreases_activity of
|
mRNA transcription
|
with ERbeta, E2 inhibited transcription
|
| 123374 |
Estradiol
|
|
increases_activity of
|
ESR2
|
with ERbeta, E2 inhibited transcription
|
| 123375 |
Estradiol
|
|
interacts (colocalizes) with
|
ESR2
|
when ERbeta is bound by E2, it may function as a negative regulator
|
| 123376 |
Estradiol
|
|
interacts (colocalizes) with
|
ESR1
|
when E2 was complexed with ERalpha, E2 activated transcription
|
|
9278514
|
|
12,867
|
| 123380 |
Estradiol
|
|
affects_activity of
|
amyloidosis
|
regulating Abeta accumulation
|
| 123381 |
Estradiol
|
|
increases_expression of
|
IDE
|
in cultured neurons and in vivo ; expression of insulin-degrading enzyme is significantly increased by both hormones and is inversely associated with the soluble Abeta levels
|
| 123387 |
Estradiol
|
|
decreases_expression of
|
ACE
|
in primary neuron cultures; concerning mRNA level
|
| 123393 |
Progesterone
|
|
decreases_activity of
|
Estradiol
|
concerning the up-regulation of IDE mRNA by continuous E2; continuous E2 was blocked by continuous P4 but not by cyclic P4
|
| 123404 |
Estradiol
|
|
increases_expression of
|
MME
|
in uterus as well as in rat brain and a neuroblastoma cell line
|
| 123436 |
Estradiol
|
|
increases_expression of
|
TTR
|
in choroid plexus and in an AD transgenic mouse model
|
| 123443 |
Estradiol
|
|
increases_activity of
|
Phosphatidylinositol 3-kinase
|
|
| 123450 |
Estradiol
|
|
decreases_expression of
|
ECE2
|
in primary neuron cultures; concerning mRNA level
|
| 123453 |
Estradiol
|
NOT |
affects_expression of
|
MME
|
in primary neuron cultures; concerning mRNA level
|
| 123458 |
Estradiol
|
NOT |
affects_expression of
|
ECE1
|
in primary neuron cultures; concerning mRNA level
|
| 123459 |
Estradiol
|
NOT |
affects_expression of
|
TTR
|
in primary neuron cultures; concerning mRNA level
|
| 123471 |
Estradiol
|
|
increases_quantity of
|
IDE
|
concerning the protein level
|
| 123496 |
Estradiol
|
|
decreases_quantity of
|
ACE
|
in various tissues, including heart, lung, kidney, and brain
|
|
22962256
|
|
13,862
|
| 131447 |
Estradiol
|
|
increases_expression of
|
SLC2A1
|
in the BBB of ovarectomized female rats and in the brain of ovarectomized female rhesus monkeys
|
| 131537 |
Estradiol
|
|
increases_expression of
|
SLC2A3
|
in brain of ovarectomized female rhesus monkeys
|
| 131538 |
Estradiol
|
|
increases_expression of
|
SLC2A4
|
in brain of ovarectomized female rhesus monkeys
|
|
32789766
|
|
14,021
|
| 132622 |
menopause transition
|
|
increases_quantity of
|
Estradiol
|
in serum of the 9‚Äď10 month regular and irregular cyclers ; serum E2 was not correlated with cortex E2 at the same endocrine stage
|
| 132627 |
menopause transition
|
|
decreases_quantity of
|
Estradiol
|
in cortex of 6 month to 9‚Äď10 month rats; serum E2 was not correlated with cortex E2 at the same endocrine stage
|
|
25921624
|
|
14,058
|
| 132900 |
Estradiol
|
|
increases_expression of
|
SLC2A1
|
in primate cerebral cortex; concerning the mRNA
|
| 132902 |
Estradiol
|
|
increases_expression of
|
SLC2A3
|
in primate cerebral cortex; concerning the mRNA
|
| 132903 |
Estradiol
|
|
increases_activity of
|
HK
|
in aged female rat brain
|
|
24244584
|
|
14,253
|
| 134494 |
Estradiol
|
|
interacts (colocalizes) with
|
APP
|
one of the top 10 E2 interacting genes in AD
|
| 134495 |
Estradiol
|
|
interacts (colocalizes) with
|
APOE
|
one of the top 10 E2 interacting genes in AD
|
| 134496 |
Estradiol
|
|
interacts (colocalizes) with
|
ATP5F1A
|
one of the top 10 E2 interacting genes in AD
|
| 134497 |
Estradiol
|
|
interacts (colocalizes) with
|
CALM1
|
one of the top 10 E2 interacting genes in AD
|
| 134498 |
Estradiol
|
|
interacts (colocalizes) with
|
CASP3
|
one of the top 10 E2 interacting genes in AD
|
| 134499 |
Estradiol
|
|
interacts (colocalizes) with
|
GSK3B
|
one of the top 10 E2 interacting genes in AD
|
| 134500 |
Estradiol
|
|
interacts (colocalizes) with
|
IL1B
|
one of the top 10 E2 interacting genes in AD
|
| 134501 |
Estradiol
|
|
interacts (colocalizes) with
|
MAPT
|
one of the top 10 E2 interacting genes in AD
|
| 134502 |
Estradiol
|
|
interacts (colocalizes) with
|
PSEN2
|
one of the top 10 E2 interacting genes in AD
|
| 134503 |
Estradiol
|
|
interacts (colocalizes) with
|
TNF
|
one of the top 10 E2 interacting genes in AD
|
|
27983596
|
AlzNet-DB