|
1,107
|
| 80460 |
Cholesterol
|
|
increases_activity of
|
Gamma-secretase complex
|
|
|
20462385
|
|
2,245
|
| 19171 |
Cholesterol
|
|
increases_activity of
|
Alzheimer disease
|
concerning serum total cholesterol level
|
|
20413858
|
|
2,249
|
| 19288 |
Cholesterol
|
|
increases_activity of
|
Alzheimer disease
|
at midlife age; concerning total blood cholesterol level
|
|
21536132
|
|
2,269
|
| 19391 |
Atorvastatin
|
|
decreases_quantity of
|
Cholesterol
|
in aged dogs
|
| 19403 |
Cholesterol
|
|
increases_activity of
|
BACE1
|
in aged dog brains; BACE1 protein levels and activity decreased and correlated with reduced brain cholesterol
|
| 19404 |
Cholesterol
|
|
increases_quantity of
|
BACE1
|
in aged dog brains; BACE1 protein levels and activity decreased and correlated with reduced brain cholesterol
|
|
20847439
|
|
2,533
|
| 23822 |
Methyl-beta-cyclodextrin
|
|
decreases_quantity of
|
Cholesterol
|
|
| 23825 |
Cholesterol
|
|
increases_activity of
|
BACE1
|
|
| 23826 |
Cholesterol
|
|
increases_activity of
|
Gamma-secretase complex
|
|
| 23827 |
Cholesterol
|
|
affects_quantity of
|
Amyloid beta peptide
|
|
| 24061 |
Cholesterol
|
|
affects_processing of
|
APP
|
The amyloidogenic processing of APP is affected.
|
| 24063 |
Cholesterol
|
|
affects_activity of
|
amyloidosis
|
|
| 24085 |
Cholesterol
|
|
affects_activity of
|
endocytosis
|
of APP and BACE1
|
| 80188 |
Cholesterol
|
|
increases_activity of
|
Ganglioside GM1
|
|
| 134818 |
Cholesterol
|
|
increases_activity of
|
Gamma-secretase complex
|
Cholesterol and sphingolipids are positive modulators of gamma-secretase activity
|
|
21448224
|
|
3,352
|
| 30774 |
APP
|
|
interacts (colocalizes) with
|
Cholesterol
|
via the flexible transmembrane domain C99
|
|
22654059
|
|
4,032
|
| 41606 |
CYP46A1
|
|
decreases_quantity of
|
Cholesterol
|
by converting cholesterol into the more hydrophilic oxysterol 24S-hydroxycholesterol
|
|
19199127
|
|
5,266
|
| 51332 |
Cholesterol
|
NOT |
affects_activity of
|
canonical Wnt signaling pathway
|
via statins
|
| 51355 |
Statin
|
|
decreases_quantity of
|
Cholesterol
|
via antagonizing HMGCR
|
|
24511465
|
|
7,288
|
| 73923 |
APOE (isoform E4)
|
|
increases_quantity of
|
Cholesterol
|
in men
|
|
11408727
|
|
7,415
|
| 72821 |
APOE KO mouse
|
|
increases_quantity of
|
Cholesterol
|
in liver and plasma; fed with 1.25% cholesterol (high-Chol diet); even when
maintained on normal chow (plasma);
|
|
21857965
|
|
7,416
|
| 72818 |
Phytosterol
|
|
decreases_quantity of
|
Cholesterol
|
in plasma of male apoE-KO mice
|
|
18155511
|
|
7,595
|
| 75814 |
Lanosterol
|
|
affects_quantity of
|
Cholesterol
|
in cytoplasm
|
|
28298292
|
|
7,773
|
| 77653 |
APOE (isoform E4)
|
|
increases_quantity of
|
Cholesterol
|
in plasma
|
|
28697566
|
|
7,818
|
| 80289 |
APOE
|
|
increases_transport of
|
Cholesterol
|
in brain; between neurons and glial cells
|
| 80678 |
APOE
|
|
increases_transport of
|
Cholesterol
|
|
|
22835784
|
|
7,821
|
| 81313 |
Cholesterol
|
|
decreases_activity of
|
Abeta-Glycosphingolipid (2-OH group containing) interaction
|
concerning the interaction of Abeta with glycosphingolipids that contained a 2-OH group
|
| 81314 |
Cholesterol
|
|
increases_activity of
|
Abeta-Glycosphingolipid (nonhydroxylated fatty acid containing) interaction
|
concerning the interaction of Abeta with glycosphingolipids that contained non-hydroxylated fatty acids
|
|
20452460
|
|
7,822
|
| 79511 |
Cholesterol
|
|
is localized in
|
membrane raft
|
|
|
20110596
|
|
7,827
|
| 79449 |
Cholesterol
|
|
is localized in
|
membrane
|
|
| 79450 |
aging
|
|
increases_quantity of
|
Cholesterol
|
in brain cells
|
| 79459 |
Alzheimer disease
|
|
increases_activity of
|
Cholesterol
|
in the middle frontal gyrus of AD patients; free cholesterol was increased
|
| 79473 |
alpha-Tocopherol
|
|
decreases_quantity of
|
Cholesterol
|
in neurons
|
|
14970312
|
|
7,848
|
| 78309 |
Alzheimer disease
|
|
increases_quantity of
|
Cholesterol
|
in the middle frontal gyrus grey matter of AD patients compared to normal subjects
|
| 78329 |
APOE (isoform E4)
|
|
increases_quantity of
|
Cholesterol
|
in the MFG (middle frontal gyrus) grey matter of AD patients (in the cell bodies but not in the fiber tracks); compared with AD patients expressing ApoE3
|
|
17888544
|
|
8,036
|
| 79455 |
aging
|
|
increases_quantity of
|
Cholesterol
|
in cortical tissue; concerning free cholesterol
|
|
14970312
|
|
8,037
|
| 79482 |
Amyloid beta peptide (42)
|
|
increases_quantity of
|
Cholesterol
|
in cultured hippocampal neurons
|
| 79490 |
lipid peroxidation
|
|
affects_quantity of
|
Cholesterol
|
in cultured hippocampal neurons; exposed to Abeta(42)
|
| 79499 |
alpha-Tocopherol
|
|
decreases_quantity of
|
Cholesterol
|
in cultured hippocampal neurons; when exposed to Abeta(42) and pretreated with alpha-tocopherol
|
|
14970312
|
|
8,123
|
| 81465 |
Alzheimer disease
|
|
increases_quantity of
|
Cholesterol
|
in serum; measured by GC-MS
(Spain)
|
|
28301062
|
|
8,145
|
| 81761 |
Cholesterol
|
|
is localized in
|
membrane raft
|
|
|
25206748
|
|
8,197
|
| 82456 |
Cholesterol
|
|
interacts (colocalizes) with
|
Tetraspanin-enriched microdomain
|
|
| 82750 |
Alzheimer disease
|
|
decreases_quantity of
|
Cholesterol
|
in AD brain
|
| 82751 |
Alzheimer disease
|
|
increases_quantity of
|
Cholesterol
|
|
| 82753 |
Lanosterol
|
|
increases_quantity of
|
Cholesterol
|
cholesterol precursors are lanosterol and lathosterol
|
| 82754 |
Lathosterol
|
|
increases_quantity of
|
Cholesterol
|
cholesterol precursors are lanosterol and lathosterol
|
| 82757 |
cholesterol biosynthetic process
|
|
increases_quantity of
|
Cholesterol
|
|
| 82758 |
Cholesterol
|
|
affects_activity of
|
Amyloid beta peptide (oligomer)
|
in the membranes
|
| 82830 |
Methyl-beta-cyclodextrin
|
|
decreases_quantity of
|
Cholesterol
|
in cells
|
| 83012 |
Cholesterol
|
|
interacts (colocalizes) with
|
APP (CTF-C99)
|
promoting amyloidogenic processing
|
| 83013 |
Cholesterol
|
|
increases_quantity of
|
amyloid beta deposits
|
|
| 83015 |
Cholesterol
|
|
interacts (colocalizes) with
|
APP
|
at the alpha-secretase cleavage sites
|
| 83017 |
Cholesterol
|
|
decreases_activity of
|
Abeta-induced cytotoxicity
|
in neuronal cells; cholesterol in physiological concentrations
|
| 83018 |
Cholesterol
|
|
decreases_activity of
|
Abeta-derived diffusible ligands
|
in SH-SY5Y cells; concerning the binding of ADDLs (soluble oligomers of Abeta) to the plasma membrane
|
| 83028 |
Amyloid beta peptide
|
|
interacts (colocalizes) with
|
Cholesterol
|
preventing its interaction with low-density lipoprotein
|
| 83029 |
Amyloid beta peptide (40)
|
|
decreases_quantity of
|
Cholesterol
|
via inhibiting the key enzyme in the biosynthesis of cholesterol
|
| 94414 |
Cholesterol
|
|
increases_quantity of
|
amyloid beta deposits
|
|
|
22737128
|
|
8,200
|
| 83110 |
Cholesterol
|
|
increases_activity of
|
Gamma-secretase complex
|
|
|
18539594
|
|
8,364
|
| 84840 |
Cholesterol
|
NOT |
affects_quantity of
|
Amyloid beta peptide (42, oligomer)
|
in the presence of rat brain lipid rafts and gangliosides
|
|
16721824
|
|
8,413
|
| 85406 |
Alzheimer disease
|
|
increases_quantity of
|
Cholesterol
|
in plasma
|
|
20050287
|
|
8,571
|
| 88118 |
DHCR24
|
NOT |
affects_quantity of
|
Cholesterol
|
concerning total cellular cholesterol;
if DHCR24 is overexpressed; reducing the loss of neurons
|
|
29115990
|
|
8,578
|
| 88376 |
DHCR24
|
|
increases_quantity of
|
Cholesterol
|
in membrane of human SH-SY5Y neuroblastoma cells; thus, protecting neuroblastoma cells against Abeta toxicity
|
| 88379 |
Cholesterol
|
|
decreases_activity of
|
Amyloid beta peptide (42, oligomer)
|
concerning the interaction of Abeta aggregates with the cell membrane
|
|
18194465
|
|
8,658
|
| 89990 |
Alzheimer disease
|
|
decreases_quantity of
|
Cholesterol
|
in frontal cortex; together with low levels of estrogen in menopause, in Alzheimer’s disease at late stages (ADV-VI)
|
| 89992 |
double-transgenic APP/presenilin mouse
|
|
decreases_quantity of
|
Cholesterol
|
in aged (14 months old) mice, in neocortex; highly significant
|
| 89997 |
Parkinson disease
|
|
decreases_quantity of
|
Cholesterol
|
in frontal cortex; in Incidental Parkinson disease and Parkinson disease
|
| 90000 |
Gaucher disease
|
|
decreases_quantity of
|
Cholesterol
|
in occipital cortex from sheep
|
| 90060 |
Alzheimer disease
|
|
decreases_quantity of
|
Cholesterol
|
in temporal cortex; in early and late stages of Alzheimer’s
|
| 90098 |
Dementia, Lewy body
|
|
decreases_quantity of
|
Cholesterol
|
in frontal cortex; in Dementia with Lewy bodies
|
| 90179 |
Cholesterol
|
|
is localized in
|
brain
|
concerning total unesterified cholesterol
|
| 90180 |
Cholesterol
|
|
affects_activity of
|
membrane raft organization
|
lipid rafts microstructure
|
|
29559883
|
|
8,779
|
| 91642 |
Cholesterol
|
|
affects_activity of
|
endosomal transport
|
|
|
23684647
|
AlzNet-DB