|
1,608
|
| 11830 |
Alzheimer disease
|
|
decreases_quantity of
|
ATP
|
in mitochondria from AD platelets
|
| 11831 |
mitochondrion
|
|
decreases_quantity of
|
ATP
|
in mitochondria from AD platelets
|
| 11834 |
APP transgenic mouse
|
|
decreases_quantity of
|
ATP
|
in neurons; from APP transgenic mice
|
|
20463408
|
|
1,667
|
| 12291 |
Alzheimer disease
|
|
decreases_quantity of
|
ATP
|
in platelets
|
| 12294 |
Mitochondrial respiratory chain complex IV
|
|
affects_quantity of
|
ATP
|
|
|
14675736
|
|
1,669
|
| 12308 |
Amyloid beta peptide (25-35)
|
|
decreases_quantity of
|
ATP
|
in neurons and astrocytes
|
|
12270688
|
|
1,680
|
| 12551 |
PC-12 cell
|
|
decreases_quantity of
|
ATP
|
|
|
15591653
|
|
1,862
|
| 14090 |
APP
|
|
decreases_quantity of
|
ATP
|
if APP is overexpressed
|
|
19050078
|
|
8,023
|
| 79396 |
APP
|
|
decreases_quantity of
|
ATP
|
due to mitochondrial impairments
|
| 79398 |
neurosteroid
|
|
increases_quantity of
|
ATP
|
in APP/Abeta overexpressing cells
|
| 79400 |
MAPT-hyperphos
|
|
decreases_quantity of
|
ATP
|
due to mitochondrial impairments
|
| 79406 |
Progesterone
|
|
increases_quantity of
|
ATP
|
in mutant tau cells
|
| 79407 |
Estradiol
|
|
increases_quantity of
|
ATP
|
in mutant tau cells
|
|
26198711
|
|
8,979
|
| 94337 |
4-Hydroxynonenal
|
|
decreases_quantity of
|
ATP
|
in cells; after inducing accumulation of mitochondrial reactive oxygen species and causing concentration-dependent decreases in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction
|
| 94339 |
Amyloid beta peptide
|
|
decreases_quantity of
|
ATP
|
in cells; after inducing accumulation of mitochondrial reactive oxygen species and causing concentration-dependent decreases in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction
|
| 94341 |
FeSO4
|
|
decreases_quantity of
|
ATP
|
in cells; after inducing accumulation of mitochondrial reactive oxygen species and causing concentration-dependent decreases in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction
|
|
9202320
|
|
10,771
|
| 109704 |
APOE (isoform E4)
|
|
decreases_quantity of
|
ATP
|
in the brain of female 16-month-old APOE4-targeted replacement mice; compared to APOE3 mice
|
| 109705 |
Curcumin
|
|
increases_quantity of
|
ATP
|
numerically in APOE3 female mice and significantly in APOE4 mice ; compared to the respective controls
|
|
24671632
|
|
11,300
|
| 113546 |
positive regulation of mitochondrial calcium ion concentration
|
|
increases_quantity of
|
ATP
|
in mitochondria; via enhanced electron activity
|
| 115756 |
mitochondrial enzymes
|
|
increases_quantity of
|
ATP
|
in physiological condition; facilitating TCA cycle and oxidative phosphorylation
|
|
30590907
|
|
11,419
|
| 114150 |
APOE (isoform E4)
|
|
decreases_quantity of
|
ATP
|
in apoE4 cells; by OXPHOS under basal conditions, compared to apoE3-expressing neurons
|
| 114186 |
APOE (isoform E4)
|
|
increases_quantity of
|
ATP
|
in apoE4 cells; via glycolysis under basal condition, compared to apoE3 cells
|
| 114295 |
ATP biosynthetic process
|
|
increases_quantity of
|
ATP
|
|
|
30883359
|
|
11,491
|
| 114713 |
ATP
|
|
interacts (colocalizes) with
|
ITPR
|
allosteric IP3R modulator
|
| 114721 |
ATP
|
|
affects_activity of
|
ITPR
|
allosteric IP3R modulator
|
|
29253316
|
|
11,639
|
| 115809 |
female brain mitochondria
|
|
increases_quantity of
|
ATP
|
in large rat cerebral arteries; compared to male mitochondria
|
|
28424375
|
|
12,066
|
| 118536 |
aging
|
|
decreases_quantity of
|
ATP
|
via electron transport chain impairments
|
| 118537 |
Estrogen
|
|
increases_quantity of
|
ATP
|
Estrogen has been shown to ameliorate the ATP production
|
|
29755342
|
|
12,180
|
| 119452 |
decreased mitochondrion activity
|
|
decreases_quantity of
|
ATP
|
via interaction of full-length Abeta or truncated forms with mitochondria and inhibition of electron transport chain enzyme complexes and reductions in the activities of tricarboxylic acid cycle enzymes, leading to inhibition of ATP production
|
|
18845536
|
|
12,926
|
| 123831 |
APOE (isoform E4)
|
|
decreases_quantity of
|
ATP
|
in APOE4 mice; compared to ApoE3 mice
|
| 123836 |
SIRT3
|
|
increases_quantity of
|
ATP
|
in ApoE4 neurons; when SIRT3 is overexpressed
|
|
31808750
|
|
13,416
|
| 126451 |
fatty acid beta-oxidation
|
|
increases_quantity of
|
ATP
|
in neurons; demanding more oxygen than glucose, thereby enhancing the risk for neurons to become hypoxic
|
| 126494 |
Glucose
|
|
increases_quantity of
|
ATP
|
|
|
23921897
|
|
13,651
|
| 128337 |
ATP
|
|
increases_activity of
|
NADH/NAD+ ratio
|
linked via glycolysis
|
| 128338 |
canonical glycolysis
|
|
increases_quantity of
|
ATP
|
|
| 128339 |
oxidative phosphorylation
|
|
increases_quantity of
|
ATP
|
|
|
22353463
|
|
13,668
|
| 128531 |
lactate utilization
|
|
increases_quantity of
|
ATP
|
in brain; under stress conditions, adapting to utilize auxiliary fuel sources in response to an energy crisis for generating ATP
|
| 128532 |
ketone body catabolic process
|
|
increases_quantity of
|
ATP
|
in brain; under stress conditions, adapting to utilize auxiliary fuel sources in response to an energy crisis for generating ATP
|
| 128533 |
glucose utilization
|
|
increases_activity of
|
ATP
|
in brain; as primary fuel source, under normal condition
|
|
32444841
|
|
13,764
|
| 129547 |
Pyruvate
|
|
increases_quantity of
|
ATP
|
in mitochondria; end product of glycolysis is pyruvate that enters the mitochondria
|
| 129650 |
Acetoacetate
|
|
increases_quantity of
|
ATP
|
the complete oxidation of AcAc yields 23 molecules of ATP
|
| 129651 |
(R)-3-Hydroxybutanoate
|
|
increases_quantity of
|
ATP
|
the complete oxidation of 3HB generates 26 molecules of ATP
|
|
28438892
|
|
13,861
|
| 130568 |
GCK
|
|
affects_quantity of
|
ATP
|
concerning D-glucose-induced increase of intracellular ATP
|
|
32789766
|
|
13,862
|
| 131524 |
ATP hydrolysis
|
|
decreases_quantity of
|
ATP
|
in response to neuronal activation, increased intracellular Na+ stimulates the Na+-K+-ATPase, leading to an decreased ATP/(ADP + AMP) ratio
|
|
32789766
|
|
14,959
|
| 140238 |
TREM2-deficient microglia
|
|
decreases_quantity of
|
ATP
|
|
|
|
|
15,273
|
| 144352 |
TNF
|
|
decreases_quantity of
|
ATP
|
when released from activated ECs
|
|
|
|
15,707
|
| 148830 |
decreased energy level
|
|
decreases_quantity of
|
ATP
|
in brain; leading to a cascade of further downstream failure of energy-dependent processes
|
| 148841 |
myelin catabolic process
|
|
increases_quantity of
|
ATP
|
in brain; when generation of energy from systemic ketones is compromised
|
|
|
|
15,713
|
| 149020 |
ATP biosynthetic process
|
|
increases_quantity of
|
ATP
|
in mitochondria
|
|
|
|
15,715
|
| 149122 |
VDAC1
|
|
increases_quantity of
|
ATP
|
|
|
|
|
15,918
|
| 153532 |
increased circulating ammonia level
|
|
decreases_quantity of
|
ATP
|
in astroglia
|
|
|
AlzNet-DB