|
122
|
| 620 |
response to oxidative stress
|
|
decreases_activity of
|
GSK3B
|
|
|
11527574
|
|
457
|
| 2078 |
response to oxidative stress
|
|
increases_activity of
|
GSK3B
|
|
| 36317 |
response to oxidative stress
|
|
increases_activity of
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
|
|
19712582
|
|
533
|
| 2671 |
response to oxidative stress
|
|
increases_quantity of
|
NEFH-mod
|
|
|
18635547
|
|
908
|
| 5414 |
Alzheimer disease
|
|
increases_activity of
|
response to oxidative stress
|
|
| 5416 |
response to oxidative stress
|
|
affects_quantity of
|
Amyloid beta peptide (39-43)
|
|
| 5557 |
Curcumin
|
|
increases_activity of
|
response to oxidative stress
|
|
| 10906 |
response to oxidative stress
|
|
affects_quantity of
|
Amyloid beta peptide (42)
|
|
|
19191039
|
|
999
|
| 6205 |
amyloid beta deposits
|
|
affects_activity of
|
response to oxidative stress
|
|
| 6208 |
Ginkgo biloba
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 6209 |
alpha-Tocopherol
|
|
decreases_activity of
|
response to oxidative stress
|
|
|
17086105
|
|
1,068
|
| 6844 |
CDK5
|
|
affects_activity of
|
response to oxidative stress
|
|
| 20823 |
CDK5
|
|
increases_activity of
|
response to oxidative stress
|
|
|
18691386
|
|
1,107
|
| 7514 |
response to oxidative stress
|
|
affects_activity of
|
Alzheimer disease
|
in hippocampus (BTO:0000601)
|
| 7581 |
Carnosol
|
|
affects_activity of
|
response to oxidative stress
|
|
| 7583 |
Zerumbone
|
|
affects_activity of
|
response to oxidative stress
|
|
| 7585 |
Resveratrol
|
|
affects_activity of
|
response to oxidative stress
|
|
| 7587 |
Rosolic acid
|
|
affects_activity of
|
response to oxidative stress
|
Rosolic acid (Pubchem: 10375289)
|
| 7589 |
Sulforaphane
|
|
affects_activity of
|
response to oxidative stress
|
1-Isothiocyanato-4-methylsulfinylbutane
|
| 20816 |
HMOX1
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 20818 |
Rosolic acid
|
|
decreases_activity of
|
response to oxidative stress
|
Rosolic acid (Pubchem: 10375289)
|
| 20819 |
Resveratrol
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 20820 |
Zerumbone
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 20821 |
Sulforaphane
|
|
decreases_activity of
|
response to oxidative stress
|
1-Isothiocyanato-4-methylsulfinylbutane
|
| 20822 |
Carnosol
|
|
decreases_activity of
|
response to oxidative stress
|
|
|
20462385
|
|
1,250
|
| 8458 |
response to oxidative stress
|
|
increases_activity of
|
Alzheimer disease
|
in frontal, parietal, and temporal lobes
|
| 8462 |
response to oxidative stress
|
|
affects_activity of
|
mitochondrion
|
|
| 8466 |
response to oxidative stress
|
|
increases_quantity of
|
Oxidized DNA base
|
in frontal, parietal, and temporal lobes
|
| 8467 |
response to oxidative stress
|
|
increases_activity of
|
DNA damage
|
in temporal lobe (in nucleus and 10-fold higher in mitochondrion)
|
|
15857398
|
|
1,309
|
| 8997 |
Ibuprofen
|
|
affects_activity of
|
response to oxidative stress
|
induced by AD
|
| 20817 |
Ibuprofen
|
|
decreases_activity of
|
response to oxidative stress
|
induced by AD
|
|
20696495
|
|
1,377
|
| 9447 |
Amyloid beta peptide
|
|
increases_activity of
|
response to oxidative stress
|
via Abeta aggregation
|
| 9448 |
response to oxidative stress
|
|
increases_quantity of
|
Amyloid beta peptide
|
as oxidant agents increase the production of Abeta
|
| 9451 |
response to oxidative stress
|
|
increases_quantity of
|
Oxidizing agent
|
|
| 9459 |
aging
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 9461 |
aging
|
|
increases_activity of
|
response to oxidative stress
|
|
| 9462 |
hyperglycemia
|
|
increases_activity of
|
response to oxidative stress
|
|
| 9463 |
response to hypoxia
|
|
increases_activity of
|
response to oxidative stress
|
|
| 9533 |
amyloid beta deposits
|
|
affects_activity of
|
response to oxidative stress
|
Toxic forms of aggregated Abeta peptides favor Ca2+ influx into neurons by inducing membrane-associated OS (oxidative stress).
|
| 9550 |
response to oxidative stress
|
|
increases_activity of
|
Gamma-secretase complex
|
|
| 9551 |
response to oxidative stress
|
|
increases_expression of
|
BACE1
|
|
|
20552043
|
|
1,418
|
| 9823 |
Fe2+
|
|
increases_activity of
|
response to oxidative stress
|
|
| 9830 |
response to oxidative stress
|
|
increases_activity of
|
Alzheimer disease
|
|
|
20817278
|
|
1,420
|
| 9854 |
APP
|
|
decreases_activity of
|
response to oxidative stress
|
|
|
20817278
|
|
1,422
|
| 9955 |
MT3
|
|
affects_activity of
|
response to oxidative stress
|
|
| 9976 |
APP
|
|
decreases_activity of
|
response to oxidative stress
|
|
|
19021541
|
|
1,510
|
| 10685 |
Ferulate
|
|
increases_activity of
|
response to oxidative stress
|
|
|
18400211
|
|
1,520
|
| 10787 |
response to oxidative stress
|
|
increases_expression of
|
BACE1
|
|
|
18687504
|
|
1,533
|
| 10953 |
abnormal iron level
|
|
increases_activity of
|
response to oxidative stress
|
|
|
17014365
|
|
1,576
|
| 11361 |
APP
|
|
increases_activity of
|
response to oxidative stress
|
in AD brains
|
|
20442493
|
|
1,582
|
| 11396 |
H2O2
|
|
increases_activity of
|
response to oxidative stress
|
|
| 11416 |
APP-mut
|
|
increases_activity of
|
response to oxidative stress
|
|
|
16551656
|
|
1,588
|
| 11653 |
acute inflammatory response
|
|
affects_activity of
|
response to oxidative stress
|
|
| 11656 |
response to oxidative stress
|
|
affects_activity of
|
mitochondrion
|
|
|
20463396
|
|
1,608
|
| 11795 |
response to oxidative stress
|
|
increases_activity of
|
abnormal neuron physiology
|
|
| 11905 |
ABAD-Abeta complex
|
|
affects_activity of
|
response to oxidative stress
|
in mitochondria
|
|
20463408
|
|
1,846
|
| 13960 |
Mitochondrial respiratory chain complex IV
|
|
affects_activity of
|
response to oxidative stress
|
in neuron
|
| 13973 |
abnormal mitochondrial physiology
|
|
affects_activity of
|
response to oxidative stress
|
in neuron
|
| 121250 |
decreased mitochondrial respiratory chain complex IV activity
|
|
decreases_activity of
|
response to oxidative stress
|
in neuron
|
|
19795195
|
|
1,864
|
| 14119 |
COX10 KO mouse
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 20824 |
COX10 KO mouse
|
|
affects_activity of
|
response to oxidative stress
|
|
| 136869 |
COX10
|
|
affects_activity of
|
response to oxidative stress
|
in brain of COX10 KO mice
|
| 136871 |
COX10
|
|
affects_activity of
|
response to oxidative stress
|
in brain of COX10 KO mice
|
|
17715058
|
|
1,888
|
| 14345 |
microglial cell activation
|
|
increases_activity of
|
response to oxidative stress
|
|
|
18313368
|
|
1,914
|
| 14803 |
glutathione biosynthetic process
|
|
affects_activity of
|
response to oxidative stress
|
Oxidative stress is induced by inhibition of glutathione biosynthesis.
|
| 14819 |
response to oxidative stress
|
|
affects_activity of
|
microglia
|
in human
|
| 14821 |
response to oxidative stress
|
|
affects_activity of
|
astrocyte
|
in human
|
| 14823 |
response to oxidative stress
|
|
affects_activity of
|
THP-1 cell
|
in human
|
| 14850 |
response to oxidative stress
|
|
affects_activity of
|
inflammatory response
|
Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis is correlated with activation of the inflammatory pathways.
|
| 14852 |
response to oxidative stress
|
|
affects_activity of
|
p38 MAPK
|
Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis is correlated with activation of the inflammatory pathways.
|
| 14854 |
response to oxidative stress
|
|
affects_activity of
|
JUN kinase kinase
|
Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis is correlated with activation of the inflammatory pathways.
|
| 14856 |
response to oxidative stress
|
|
affects_activity of
|
NF-kappaB complex
|
Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis is correlated with activation of the inflammatory pathways.
|
| 106879 |
response to oxidative stress
|
|
affects_activity of
|
NF-kappaB complex
|
Oxidative stress is correlated with activation of the inflammatory pathway NF-kappaB.
|
|
20228251
|
|
1,957
|
| 15181 |
decreased metabolic process
|
|
increases_activity of
|
response to oxidative stress
|
disruptions in metabolism lead to increased free radical production
|
| 15183 |
Reactive oxygen species
|
|
increases_activity of
|
response to oxidative stress
|
|
| 15184 |
Free radical
|
|
increases_activity of
|
response to oxidative stress
|
|
| 15185 |
O2-
|
|
increases_activity of
|
response to oxidative stress
|
|
| 15189 |
NO
|
|
increases_activity of
|
response to oxidative stress
|
|
| 15194 |
Peroxynitrite
|
|
increases_activity of
|
response to oxidative stress
|
|
| 15239 |
response to oxidative stress
|
|
increases_activity of
|
Lipoxygenase
|
in brain of AD patients
|
| 15261 |
response to oxidative stress
|
|
increases_activity of
|
protein oxidation
|
in AD patients; around the areas of plaques and tangles and also in other areas
|
| 15306 |
response to oxidative stress
|
|
increases_quantity of
|
Hydroxynonenal
|
elevated in brains of both AD patients and animals with impaired brain metabolism
|
| 15528 |
response to oxidative stress
|
|
increases_quantity of
|
Malonaldehyde
|
|
|
19076444
|
|
1,994
|
| 15719 |
Puerarin
|
|
affects_activity of
|
response to oxidative stress
|
|
| 15741 |
response to oxidative stress
|
|
affects_activity of
|
apoptotic process
|
|
|
20933077
|
|
2,023
|
| 16086 |
response to oxidative stress
|
|
increases_expression of
|
NOS2
|
|
| 16089 |
response to oxidative stress
|
|
increases_expression of
|
NOS1
|
|
|
21383494
|
|
2,057
|
| 16440 |
Nebivolol
|
|
affects_activity of
|
response to oxidative stress
|
|
| 16442 |
response to oxidative stress
|
|
affects_activity of
|
neuron
|
|
|
20128815
|
|
2,072
|
| 16721 |
Acetylcarnitine
|
|
affects_activity of
|
response to oxidative stress
|
in ApoE4 mice
|
| 16722 |
R-alpha-lipoic acid
|
|
affects_activity of
|
response to oxidative stress
|
in ApoE4 mice
|
|
19342064
|
|
2,192
|
| 18330 |
Olmesartan
|
|
decreases_activity of
|
response to oxidative stress
|
in brain microvessels; (Olmesartan is an antihypertensive drug)
|
|
19805638
|
AlzNet-DB