|
683
|
| 3766 |
Dantrolene
|
|
decreases_activity of
|
neuron death
|
PSEN2-N141I enhanced
|
|
16394273
|
|
843
|
| 5006 |
SERTAD1
|
|
affects_activity of
|
neuron death
|
in cerebral cortex
|
|
20237268
|
|
908
|
| 5441 |
Reactive oxygen species
|
|
increases_activity of
|
neuron death
|
in astrocytes; if ROS production is Abeta-induced
|
|
19191039
|
|
1,257
|
| 8517 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
neuron death
|
|
|
11733217
|
|
1,511
|
| 10689 |
Amyloid beta peptide (protofibrillar)
|
|
increases_activity of
|
neuron death
|
through rapid electrophysiological changes
|
|
16205720
|
|
1,534
|
| 10964 |
APP-TNFRSF21 complex
|
|
increases_activity of
|
neuron death
|
via caspases
|
|
19225519
|
|
1,566
|
| 11203 |
neuron death
|
|
increases_activity of
|
response to stress
|
a stress response to neuronal damage is microglia activation
|
| 11288 |
NADPH oxidase complex
|
|
increases_activity of
|
neuron death
|
(microglia-mediated Abeta neurotoxicity)
|
|
19090996
|
|
1,681
|
| 12576 |
Verapamil
|
|
decreases_activity of
|
neuron death
|
via (APP CTF)-induced neurotoxicity
|
| 12578 |
Diltiazem
|
|
decreases_activity of
|
neuron death
|
via (APP CTF)-induced neurotoxicity
|
| 12579 |
Isradipine
|
|
decreases_activity of
|
neuron death
|
via (APP CTF)-induced neurotoxicity
|
| 12580 |
Nimodipine
|
|
decreases_activity of
|
neuron death
|
via (APP CTF)-induced neurotoxicity
|
|
20816785
|
|
1,953
|
| 15127 |
Humanin
|
|
decreases_activity of
|
neuron death
|
via Abeta neurotoxicity
|
|
18813209
|
|
1,957
|
| 15326 |
H2O2
|
|
increases_activity of
|
neuron death
|
|
| 15327 |
Reactive oxygen species
|
|
increases_activity of
|
neuron death
|
|
|
19076444
|
|
1,984
|
| 15668 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
neuron death
|
via bax overexpression, bcl-2 down-regulation, and caspase-3 activation
|
| 15695 |
BAX
|
|
increases_activity of
|
neuron death
|
via bax overexpression
|
| 15696 |
BCL2
|
|
decreases_activity of
|
neuron death
|
|
| 15697 |
CASP3
|
|
increases_activity of
|
neuron death
|
via caspase-3 activation
|
|
16472763
|
|
2,048
|
| 16363 |
Amyloid beta peptide (3pE-42)
|
|
affects_activity of
|
neuron death
|
if AbetapE3-42 is overexpressed in TBA2 mice
|
|
21148560
|
|
2,050
|
| 16417 |
Amyloid beta peptide (3pE-42)
|
|
increases_activity of
|
neuron death
|
via elevated neurotoxicity.
|
| 16418 |
Amyloid beta peptide (3pE-40)
|
|
increases_activity of
|
neuron death
|
via elevated neurotoxicity.
|
|
19863057
|
|
2,181
|
| 18259 |
Amyloid beta peptide (endogenous)
|
|
increases_activity of
|
neuron death
|
|
|
19628305
|
|
2,389
|
| 21139 |
astrocyte
|
|
increases_activity of
|
neuron death
|
when Abeta-induced
|
|
21633390
|
|
2,423
|
| 21850 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
neuron death
|
via Abeta(1-42)-induced neurotoxicity.
|
| 22478 |
Schisandrin B
|
|
decreases_activity of
|
neuron death
|
via Abeta(1-42)-induced neurotoxicity.
|
|
19694182
|
|
2,577
|
| 24332 |
G3Terc KO mouse
|
|
increases_activity of
|
neuron death
|
in hippocampus and frontal cortex of G3Terc-/- mice; compared to mice with long telomere reserves (Terc+/+ )
|
|
21672962
|
|
2,587
|
| 24413 |
Myricetin
|
|
decreases_activity of
|
neuron death
|
caused by Abeta neurotoxicity
|
|
17722071
|
|
3,152
|
| 29018 |
PRNP
|
|
increases_activity of
|
neuron death
|
Abeta oligomer-induced
|
| 29019 |
neuron death
|
|
increases_activity of
|
cognitive impairment
|
|
| 29020 |
Z-VAD-FMK
|
|
decreases_activity of
|
neuron death
|
|
| 29022 |
Amyloid beta peptide (oligomer)
|
|
increases_activity of
|
neuron death
|
if bound to PrPC
|
| 29024 |
PRNP/Amyloid beta peptide binding
|
|
affects_activity of
|
neuron death
|
via Abeta oligomer-mediated neurotoxicity.
|
| 29025 |
(2R)-amino-5-phosphonovaleric acid
|
|
decreases_activity of
|
neuron death
|
via Abeta oligomer-mediated neurotoxicity.
|
| 29031 |
Prion disease
|
|
increases_activity of
|
neuron death
|
via Abeta oligomer-mediated neurotoxicity.
|
|
22100763
|
|
3,339
|
| 30688 |
Amyloid beta peptide (LNO)
|
|
increases_activity of
|
neuron death
|
in cultured neurons
|
|
22660329
|
|
3,761
|
| 36762 |
Advanced glycation end-product
|
|
increases_activity of
|
neuron death
|
in an Abeta-rich environment; via neurotoxicity.
|
| 36788 |
Quinolinic acid
|
|
affects_activity of
|
neuron death
|
|
| 37003 |
TNFRSF1A
|
|
affects_activity of
|
neuron death
|
via a cytoplasmic death domain in TNFR1, induced by Abeta protein in the AD brain
|
| 37207 |
TGFB2
|
|
increases_activity of
|
neuron death
|
|
| 37301 |
NADPH oxidase complex
|
|
affects_activity of
|
neuron death
|
in microglia; via neurotoxicity.
|
|
22970774
|
|
3,784
|
| 37360 |
Silibinin
|
|
decreases_activity of
|
neuron death
|
in PC12 cells; caused by Abeta neurotoxicity.
|
|
21071836
|
|
6,481
|
| 62286 |
IAPP
|
|
increases_activity of
|
neuron death
|
in embryonic rat hippocampal primary cultures in vitro; caused by amylin neurotoxicity.
|
|
25998028
|
|
7,322
|
| 115238 |
Estrogen
|
|
decreases_activity of
|
neuron death
|
via reducing amyloid-beta aggregations; estrogen has neuroprotective effects
|
|
24470773
|
|
7,827
|
| 79474 |
alpha-Tocopherol
|
|
decreases_activity of
|
neuron death
|
|
|
14970312
|
|
8,037
|
| 79484 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
neuron death
|
in cultured hippocampal neurons
|
|
14970312
|
|
8,158
|
| 81941 |
VDAC1
|
|
increases_activity of
|
neuron death
|
if VDAC1 is progressively dephosphorylated
|
|
27814578
|
|
8,411
|
| 85757 |
decreased lysosomal breakdown
|
|
decreases_activity of
|
neuron death
|
|
|
26993302
|
|
8,699
|
| 90417 |
VDAC1
|
|
increases_activity of
|
neuron death
|
in lipid rafts of neurons; when exposed to Abeta, via dephosphorylation of VDAC1
|
|
25168729
|
|
9,096
|
| 95776 |
APOE4 (1-272 fragment)
|
|
increases_activity of
|
neuron death
|
The findings suggest that the lipid-binding region (amino acids 241‚Äď272) facilitates the neurotoxicity and amino acids 273‚Äď299 are protective.
|
| 95787 |
APOE4 (1-240 fragment)
|
NOT |
affects_activity of
|
neuron death
|
The findings suggest that the lipid-binding region (amino acids 241‚Äď272) facilitates the neurotoxicity and amino acids 273‚Äď299 are protective.
|
| 95788 |
APOE (isoform E4)
|
NOT |
affects_activity of
|
neuron death
|
The findings suggest that the lipid-binding region (amino acids 241‚Äď272) facilitates the neurotoxicity and amino acids 273‚Äď299 are protective.
|
| 95789 |
APOE4 (241-272 fragment)
|
|
increases_activity of
|
neuron death
|
the lipid-binding region (i.e., amino acids 241‚Äď272) facilitates the neurotoxicity but only the lipid-binding region is inadequate to cause neurotoxicity; lipid- and receptor-binding regions together impair mitochondrial function and integrity
|
| 114453 |
APOE4 (273-299 fragment)
|
|
decreases_activity of
|
neuron death
|
APOE4 aa 273‚Äď299 are protective
|
| 114455 |
APOE4 (135-150 fragment)
|
|
increases_activity of
|
neuron death
|
the receptor-binding region is required for escape from the secretory pathway; but only lipid- and receptor-binding regions together impair mitochondrial function and integrity
|
|
30032423
|
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