|
1,111
|
| 7191 |
Alzheimer disease
|
|
increases_activity of
|
microglial cell activation
|
|
|
11329064
|
|
1,112
|
| 7183 |
transgenic hAPP/TGFbeta1 mouse
|
|
increases_activity of
|
microglial cell activation
|
in transgenic hAPP/TGF-beta1 mice
|
| 7194 |
TGFB1
|
|
increases_activity of
|
microglial cell activation
|
in brain; of transgenic hAPP/TGF-beta1 mice
|
|
11329064
|
|
1,184
|
| 7845 |
microglial cell activation
|
|
increases_activity of
|
inflammatory response
|
within the diseased brain
|
| 7865 |
microglial cell activation
|
|
increases_quantity of
|
Peroxynitrite
|
|
|
17094809
|
|
1,309
|
| 8944 |
Ibuprofen
|
|
decreases_activity of
|
microglial cell activation
|
|
|
20696495
|
|
1,566
|
| 11204 |
response to stress
|
|
increases_activity of
|
microglial cell activation
|
|
| 11205 |
microglial cell activation
|
|
increases_activity of
|
Reactive oxygen species
|
|
|
19090996
|
|
1,588
|
| 11658 |
microglial cell activation
|
|
increases_quantity of
|
Reactive oxygen species
|
Activated microglia can produce and release ROS.
|
| 11675 |
microglial cell activation
|
|
increases_quantity of
|
Reactive nitrogen species
|
Activated microglia can produce and release RNS.
|
|
20463396
|
|
1,745
|
| 13185 |
amyloid beta deposits
|
|
increases_activity of
|
microglial cell activation
|
|
|
12270682
|
|
1,888
|
| 14341 |
Amyloid beta peptide
|
|
increases_activity of
|
microglial cell activation
|
|
| 14345 |
microglial cell activation
|
|
increases_activity of
|
response to oxidative stress
|
|
| 14346 |
microglial cell activation
|
|
increases_expression of
|
IL1B
|
if activated by Abeta
|
| 14347 |
microglial cell activation
|
|
increases_expression of
|
IL6
|
if activated by Abeta
|
| 14348 |
microglial cell activation
|
|
increases_expression of
|
TNF
|
if activated by Abeta
|
|
18313368
|
|
2,278
|
| 19462 |
microglial cell activation
|
|
increases_activity of
|
cytokine secretion
|
|
| 19463 |
microglial cell activation
|
|
increases_activity of
|
chemokine secretion
|
|
| 19464 |
microglial cell activation
|
|
increases_quantity of
|
IL1B
|
|
| 19465 |
microglial cell activation
|
|
increases_quantity of
|
IL6
|
|
| 19467 |
microglial cell activation
|
|
increases_quantity of
|
CCL2
|
|
| 19468 |
microglial cell activation
|
|
increases_quantity of
|
TNF
|
|
| 19535 |
Pioglitazone
|
|
decreases_activity of
|
microglial cell activation
|
in aged APPV717I transgenic mice
|
|
21345168
|
|
2,525
|
| 23524 |
Neuropeptide
|
|
increases_activity of
|
microglial cell activation
|
neuropeptides increase chemotactic activity of microglia
|
| 23551 |
microglial cell activation
|
|
increases_activity of
|
neurodegeneration
|
|
|
20937084
|
|
2,577
|
| 24271 |
decreased telomere length
|
|
increases_activity of
|
microglial cell activation
|
in ageing amyloid-free brain
|
|
21672962
|
|
2,943
|
| 26849 |
CD36-Abeta complex
|
|
increases_activity of
|
microglial cell activation
|
|
|
21835916
|
|
3,743
|
| 36368 |
APP/PS1 mouse
|
|
increases_activity of
|
microglial cell activation
|
|
| 36375 |
microglial cell activation
|
|
increases_expression of
|
IL12A-IL12B complex
|
in APPPS1 mouse model
|
| 36377 |
microglial cell activation
|
|
increases_expression of
|
IL12B
|
in APPPS1 mouse model
|
|
23178247
|
|
3,761
|
| 36783 |
microglial cell activation
|
|
increases_activity of
|
inflammatory response
|
|
| 64583 |
microglial cell activation
|
|
increases_activity of
|
NADPH oxidase complex
|
|
|
22970774
|
|
3,768
|
| 36721 |
toll-like receptor signaling pathway
|
|
affects_activity of
|
microglial cell activation
|
concerning the response to fibrillar forms of Abeta (fAbeta)
|
| 36728 |
Amyloid beta peptide (fibrillar)
|
|
increases_activity of
|
microglial cell activation
|
|
| 36746 |
CD14
|
|
affects_activity of
|
microglial cell activation
|
|
|
19776284
|
|
4,031
|
| 41522 |
IFNG
|
|
increases_activity of
|
microglial cell activation
|
if IFN-gamma is produced by amyloid beta-specific Th1 cells
|
|
23365075
|
|
6,481
|
| 62599 |
Ghrelin
|
|
decreases_activity of
|
microglial cell activation
|
if microglia activation is kainate-induced.
|
|
25998028
|
|
7,629
|
| 76336 |
Alzheimer disease
|
|
increases_activity of
|
microglial cell activation
|
in brain
|
|
18657226
|
|
10,297
|
| 106830 |
Amyloid beta peptide
|
|
increases_activity of
|
microglial cell activation
|
accumulated Abeta activated microglia
|
|
28294066
|
|
10,915
|
| 111139 |
APOE (isoform E4)
|
|
increases_activity of
|
microglial cell activation
|
in cultured mouse microglia derived from APOE4 targeted-replacement mice ; concerning activated microglia morphology; compared to APOE3, when exposed to various pro-inflammatory mediators
|
|
30804776
|
|
10,933
|
| 152932 |
C3
|
|
increases_activity of
|
microglial cell activation
|
via the C3a receptor
|
| 152933 |
Lipopolysaccharide
|
|
increases_activity of
|
microglial cell activation
|
|
| 152936 |
microglial cell activation
|
|
increases_activity of
|
astrocyte, reactive
|
concerning neurotoxic ‚Äė‚ÄėA1‚Äô‚Äô reactive astrocytes
|
|
30804776
|
|
11,022
|
| 111879 |
TYROBP
|
|
increases_activity of
|
microglial cell activation
|
TREM2 signals through the adaptor protein DAP12, that mediates TREM2 signaling and promotes microglial activation and survival
|
|
30038567
|
|
11,023
|
| 112198 |
microglial cell activation
|
|
increases_expression of
|
mir-155
|
in M1-activated microglia and in the brain of 3xTg AD mice; critical for the establishment of a chronic inflammatory phenotype
|
|
27239545
|
|
12,106
|
| 118858 |
CASP7
|
|
increases_activity of
|
microglial cell activation
|
driving neurodegeneration during AD pathogenesis
|
|
27358062
|
|
14,959
|
| 140239 |
TREM2-deficient microglia
|
|
decreases_activity of
|
microglial cell activation
|
|
|
|
|
14,963
|
| 140229 |
microglial cell activation
|
|
increases_activity of
|
phagocytosis
|
impaired in APP/PS1 mice
|
| 140230 |
microglial cell activation
|
|
decreases_quantity of
|
amyloid beta deposits
|
impaired in APP/PS1 mice
|
|
|
|
15,665
|
| 148417 |
microglial cell activation
|
|
increases_activity of
|
Alzheimer disease
|
|
| 148418 |
microglial cell activation
|
|
increases_activity of
|
abnormal energy expenditure
|
reaching a chronic tolerant phase
|
| 148421 |
microglial cell activation
|
|
decreases_activity of
|
immune response
|
|
| 148422 |
microglial cell activation
|
|
increases_activity of
|
cytokine secretion
|
|
| 148423 |
microglial cell activation
|
|
increases_activity of
|
phagocytosis
|
|
| 148426 |
microglial cell activation
|
|
affects_activity of
|
microglia
|
|
|
|
|
15,943
|
| 152941 |
Amyloid beta peptide
|
|
increases_activity of
|
microglial cell activation
|
in mouse; compared to MAPT/TAU
|
| 152942 |
MAPT
|
|
decreases_activity of
|
microglial cell activation
|
in mouse; compared to Abeta
|
|
|
AlzNet-DB