|
1,708
|
| 12840 |
BECN1
|
|
increases_activity of
|
autophagy
|
|
|
21081164
|
|
2,121
|
| 17395 |
AD11 anti-NGF mouse
|
|
affects_activity of
|
autophagy
|
|
|
19604602
|
|
3,253
|
| 30006 |
autophagy
|
|
increases_processing of
|
APP
|
|
| 30014 |
autophagy
|
|
increases_quantity of
|
Amyloid beta peptide
|
during autophagic turnover of APP-rich organelles
|
|
18032783
|
|
6,480
|
| 62045 |
Ghrelin
|
|
increases_activity of
|
autophagy
|
in colon adenocarcinoma cells (HCT116)
|
|
26033219
|
|
6,540
|
| 62205 |
Amyloid beta peptide
|
|
decreases_activity of
|
autophagy
|
in alpha-Syn- overexpressed cells
|
|
26515689
|
|
6,542
|
| 63439 |
AMPK
|
|
increases_activity of
|
autophagy
|
when AMPK is activated
|
| 63606 |
Alzheimer disease
|
|
affects_activity of
|
autophagy
|
|
| 63615 |
ULK1 complex
|
|
increases_activity of
|
autophagy
|
if ULK1 is phosphorylated.
|
| 63616 |
MTOR
|
|
decreases_activity of
|
autophagy
|
|
| 63622 |
Ca2+
|
|
increases_activity of
|
autophagy
|
by inhibition of mTOR
|
| 63759 |
Resveratrol
|
|
increases_activity of
|
autophagy
|
via activating AMPK.
|
| 63764 |
RSVA314
|
|
increases_activity of
|
autophagy
|
|
| 63769 |
RSVA405
|
|
increases_activity of
|
autophagy
|
|
| 63771 |
autophagy
|
|
decreases_quantity of
|
Amyloid beta peptide
|
via lysosomal degradation.
|
|
22367557
|
|
7,598
|
| 77583 |
Oleuropein aglycone
|
|
increases_activity of
|
autophagy
|
|
| 77584 |
Oleocanthal
|
|
increases_activity of
|
autophagy
|
|
|
27634977
|
|
8,145
|
| 81758 |
lysosome
|
|
increases_activity of
|
autophagy
|
|
| 81809 |
Alzheimer disease
|
|
affects_activity of
|
autophagy
|
|
|
25206748
|
|
8,411
|
| 85753 |
endosomal-lysosomal system
|
|
affects_activity of
|
autophagy
|
concerning the autophagy system involved in cellular homeostasis and protection
|
|
26993302
|
|
8,619
|
| 89009 |
K604
|
|
increases_activity of
|
autophagy
|
in an mTOR-independent
manner, activating the coordinated lysosomal expression and regulation network
|
|
25339759
|
|
11,568
|
| 115414 |
APOE (isoform E4)
|
|
decreases_activity of
|
autophagy
|
in the hippocampus of ApoE4 compared with the ApoE3 mice; resulting in higher levels of proteins such as parkin and p62
|
| 115416 |
autophagy
|
|
decreases_quantity of
|
PRKN
|
in the hippocampus of ApoE4 compared with the ApoE3 mice; parkin and p62 are normally degraded during this process
|
| 115417 |
autophagy
|
|
decreases_quantity of
|
SQSTM1
|
in the hippocampus of ApoE4 compared with the ApoE3 mice; parkin and p62 are normally degraded during this process
|
|
31306119
|
|
12,550
|
| 122108 |
ADNP
|
|
increases_activity of
|
autophagy
|
ADNP plays an essential role in brain development and autophagy
|
|
26791201
|
|
13,729
|
| 128970 |
TOR signaling
|
|
decreases_activity of
|
autophagy
|
activated AMPK decreases mTOR signaling activity which facilitates autophagy and promotes lysosomal degradation of Abeta
|
|
28655134
|
|
14,959
|
| 140232 |
TREM2-deficient microglia
|
|
increases_activity of
|
autophagy
|
|
|
|
|
15,119
|
| 141699 |
Phosphatidylinositol-4,5-bisphosphate
|
|
affects_activity of
|
autophagy
|
via regulation of two essential steps of autophagy
|
| 141783 |
ERK/MAPK pathway
|
|
affects_activity of
|
autophagy
|
in some cell lines; depending on isoform of APOE
|
| 141784 |
c-Jun/N-terminal kinase (JNK) pathway
|
|
affects_activity of
|
autophagy
|
in some cell lines; depending on isoform of APOE
|
| 141788 |
HSV1 infection
|
|
decreases_activity of
|
autophagy
|
in infected cells; by inhibiting PKR-eIF2alpha signaling
|
| 142482 |
response to starvation
|
|
increases_activity of
|
autophagy
|
in APOE4-target replacement murine astrocyte cell lines and corresponding primary astrocytes
|
| 142483 |
APOE (isoform E4)
|
|
affects_activity of
|
autophagy
|
in APOE4-target replacement murine astrocyte cell lines and corresponding primary astrocytes; via impairing autophagy
|
| 151391 |
impaired autophagy
|
|
decreases_activity of
|
autophagy
|
in APOE4-target replacement murine astrocyte cell lines and corresponding primary astrocytes; concerning basal and starvation-induced autophagy, compared with those expressing APOE3
|
|
|
|
15,290
|
| 144644 |
mTORC1 complex
|
|
decreases_activity of
|
autophagy
|
|
| 144651 |
mTORC1 complex
|
|
decreases_activity of
|
autophagy
|
|
| 144652 |
cellular response to stress
|
|
increases_activity of
|
autophagy
|
|
| 144654 |
negative regulation of autophagy
|
|
decreases_activity of
|
autophagy
|
|
|
|
|
15,322
|
| 144847 |
autophagy
|
|
increases_transport of
|
ATG9A
|
from the trans-Golgi network or the endocytic compartments to the omegasomes; in a ULK1- or retromer complex-dependent manner
|
| 144890 |
SQSTM1
|
|
increases_activity of
|
autophagy
|
in mice; as autophagic receptor, recognizing polyubiquitinated proteins
|
| 144899 |
autophagy
|
|
increases_activity of
|
neuronal homeostasis
|
|
| 144900 |
autophagy
|
|
decreases_activity of
|
neuronal disorder
|
via removing protein aggregates
|
| 144901 |
autophagy
|
|
decreases_activity of
|
protein aggregate formation
|
preventing neuronal disorders
|
| 144905 |
aging
|
|
decreases_activity of
|
autophagy
|
|
| 144906 |
autophagy
|
|
increases_activity of
|
HTT-mut clearance
|
dependent on the aggrephagy receptor p62
|
| 144907 |
Bafilomycin A1
|
|
decreases_activity of
|
autophagy
|
in cell culture systems and rat brains; increasing mHtt aggregates
|
| 144915 |
autophagy
|
|
increases_activity of
|
MAPT (insoluble) clearance
|
dependent on the aggrephagy receptor p62
|
| 144916 |
autophagy
|
|
increases_activity of
|
amyloid-beta (42) clearance
|
dependent on the aggrephagy receptor p62
|
| 144917 |
3-Methyladenine
|
|
decreases_activity of
|
autophagy
|
in cell culture systems and rat brains; increasing mHtt aggregates
|
| 144953 |
Amyloid beta peptide (oligomer)
|
|
decreases_activity of
|
autophagy
|
in animal models; via impairment of trafficking and lysosome biogenesis
|
| 144967 |
PICALM
|
|
affects_activity of
|
autophagy
|
|
| 145011 |
autophagy
|
|
decreases_quantity of
|
APP (C-terminal fragment)
|
|
| 145012 |
autophagy
|
|
decreases_quantity of
|
Amyloid beta peptide
|
|
| 145013 |
autophagy
|
|
increases_activity of
|
amyloid-beta clearance
|
|
| 145014 |
autophagy
|
|
increases_activity of
|
APP (C-terminal fragment) clearance
|
|
| 145044 |
autophagy
|
|
decreases_quantity of
|
MAPT-phos
|
concerning aberrant phosphorylated tau, via degradation
|
| 145049 |
autophagy
|
|
decreases_quantity of
|
MAPT-phos
|
via degradation
|
| 145056 |
autophagy
|
|
decreases_quantity of
|
MAPT-hyperphos
|
via autophagic degradation
|
|
|
|
15,346
|
| 145064 |
Rapamycin
|
|
increases_activity of
|
autophagy
|
in an mTOR-dependent manner
|
| 145066 |
Curcumin
|
|
increases_activity of
|
autophagy
|
in an mTOR-dependent manner
|
| 145075 |
ULK1 complex
|
|
increases_activity of
|
autophagy
|
|
| 145099 |
Trehalose
|
|
increases_activity of
|
autophagy
|
reducing the number of inclusion bodies
|
|
|
|
15,347
|
| 145107 |
autophagy
|
|
decreases_quantity of
|
APP (C-terminal fragment)
|
hereby decreasing Abeta peptides
|
| 145116 |
autophagy
|
|
increases_activity of
|
amyloid-beta clearance
|
via decreasing APP-CTFs
|
|
|
|
15,719
|
| 149211 |
PRKN
|
|
increases_activity of
|
autophagy
|
via promoting the degradation of whole organelles by autophagy
|
| 149261 |
autophagy
|
|
increases_activity of
|
organelle disassembly
|
via promoting the degradation of whole organelles by autophagy
|
|
|
|
15,767
|
| 149789 |
APOE (isoform E4)
|
|
decreases_activity of
|
autophagy
|
in astrocytes; compared to APOE3 astrocytes
|
| 149798 |
Rapamycin
|
|
increases_activity of
|
autophagy
|
|
|
|
|
15,797
|
| 150186 |
autophagy
|
|
decreases_quantity of
|
lipids, peroxidated
|
in membranes of excited neurons
|
| 150189 |
autophagy
|
|
increases_transport of
|
lipids, peroxidated
|
into lysosomes
|
| 150191 |
lysosome
|
|
increases_activity of
|
autophagy
|
breaking down portions of an organelle or membrane
|
|
|
AlzNet-DB