|
100
|
| 332 |
GSK3B
|
|
increases_activity of
|
apoptotic process
|
if catalytically active GSK3B is overexpressed
|
|
9685326
|
|
122
|
| 911 |
GSK3B
|
|
increases_activity of
|
apoptotic process
|
|
|
11527574
|
|
683
|
| 3778 |
Dantrolene
|
|
decreases_activity of
|
apoptotic process
|
in PC12/PS2mt cells; treated with L-glutamate and amyloid beta peptide (25-35)
|
|
16394273
|
|
809
|
| 4674 |
PDIA2
|
|
decreases_activity of
|
apoptotic process
|
|
|
16724068
|
|
843
|
| 5001 |
SERTAD1
|
|
affects_activity of
|
apoptotic process
|
|
|
20237268
|
|
908
|
| 5422 |
abnormal mitochondrial physiology
|
|
increases_activity of
|
apoptotic process
|
in astrocytes
|
|
19191039
|
|
1,510
|
| 10686 |
Ferulate
|
|
decreases_activity of
|
apoptotic process
|
|
|
18400211
|
|
1,654
|
| 12165 |
MAP3K4
|
|
affects_activity of
|
apoptotic process
|
|
| 12166 |
FOS
|
|
affects_activity of
|
apoptotic process
|
|
| 12171 |
PPM1B
|
|
affects_activity of
|
apoptotic process
|
|
|
12196559
|
|
1,984
|
| 15555 |
Amyloid beta peptide (42)
|
|
increases_activity of
|
apoptotic process
|
of IMR-32 cells
|
| 15566 |
BAX
|
|
increases_activity of
|
apoptotic process
|
|
| 15571 |
BCL2
|
|
decreases_activity of
|
apoptotic process
|
bcl-2 is an anti-apoptotic gene
|
|
16472763
|
|
1,994
|
| 15738 |
Puerarin
|
|
decreases_activity of
|
apoptotic process
|
|
| 15741 |
response to oxidative stress
|
|
affects_activity of
|
apoptotic process
|
|
|
20933077
|
|
2,181
|
| 18313 |
Amyloid beta peptide (endogenous)
|
|
affects_activity of
|
apoptotic process
|
|
|
19628305
|
|
2,841
|
| 26322 |
EMILIN2
|
|
affects_activity of
|
apoptotic process
|
|
| 26324 |
MGST1
|
|
affects_activity of
|
apoptotic process
|
|
| 26326 |
NELL1
|
|
affects_activity of
|
apoptotic process
|
|
| 26328 |
PPP2R2B
|
|
affects_activity of
|
apoptotic process
|
|
| 26330 |
RAC2
|
|
affects_activity of
|
apoptotic process
|
|
| 26332 |
SCG5
|
|
affects_activity of
|
apoptotic process
|
|
| 26334 |
SGK1
|
|
affects_activity of
|
apoptotic process
|
|
| 26337 |
LPAR1
|
|
affects_activity of
|
apoptotic process
|
|
| 26339 |
RET
|
|
affects_activity of
|
apoptotic process
|
|
| 26341 |
PRKCA
|
|
affects_activity of
|
apoptotic process
|
|
|
|
|
2,989
|
| 27286 |
apoptotic process
|
|
affects_activity of
|
neurodegeneration
|
in human AD brain
|
| 27290 |
apoptotic process
|
|
affects_activity of
|
synaptic loss
|
in human AD brain
|
|
21902456
|
|
2,999
|
| 27313 |
XIAP-phosSer87
|
|
decreases_activity of
|
apoptotic process
|
|
| 27315 |
apoptotic process
|
|
increases_activity of
|
cell death
|
|
|
21707856
|
|
3,474
|
| 32318 |
APP (cytotoxic fragment C31)
|
|
increases_activity of
|
apoptotic process
|
|
|
10742146
|
|
3,476
|
| 32321 |
NAE1
|
|
increases_activity of
|
apoptotic process
|
|
|
14557245
|
|
3,699
|
| 35892 |
glucose supplementation
|
|
increases_activity of
|
apoptotic process
|
|
|
22329649
|
|
3,761
|
| 37073 |
TNFSF10
|
|
increases_activity of
|
apoptotic process
|
of parenchymal cells
|
|
22970774
|
|
3,792
|
| 37647 |
Advanced glycation end-product
|
|
increases_activity of
|
apoptotic process
|
if AGEs are highly modified
|
|
19464758
|
|
4,090
|
| 42285 |
ProNGF
|
|
increases_activity of
|
apoptotic process
|
|
|
20158567
|
|
6,480
|
| 62044 |
Ghrelin
|
|
increases_activity of
|
apoptotic process
|
in colon adenocarcinoma cells (HCT116)
|
| 62048 |
BCL2
|
|
decreases_activity of
|
apoptotic process
|
|
|
26033219
|
|
6,687
|
| 64641 |
GADD45A
|
|
decreases_activity of
|
apoptotic process
|
in AD brain tissue
|
|
9848094
|
|
7,825
|
| 79558 |
sphingosine-1-phosphate receptor signaling pathway
|
|
decreases_activity of
|
apoptotic process
|
|
|
17342407
|
|
7,906
|
| 78839 |
N-Acylsphingosine
|
|
increases_activity of
|
apoptotic process
|
|
| 78928 |
Sphingosine 1-phosphate
|
|
decreases_activity of
|
apoptotic process
|
|
|
15610181
|
|
8,035
|
| 79413 |
Tauroursodeoxycholic acid
|
|
decreases_activity of
|
apoptotic process
|
|
|
25443293
|
|
8,411
|
| 85288 |
Retinoic acid
|
|
increases_activity of
|
apoptotic process
|
via binding to the the
IGF-II/M6P receptor (=IGF2R)
|
| 85604 |
GZMB
|
|
increases_activity of
|
apoptotic process
|
via binding to the the
IGF-II/M6P receptor (=IGF2R)
|
|
26993302
|
|
8,575
|
| 88295 |
CASP3
|
|
increases_activity of
|
apoptotic process
|
|
|
15954227
|
|
8,588
|
| 88510 |
NMDA receptor complex
|
|
increases_activity of
|
apoptotic process
|
in entorhinal cortex and hippocampal slice cultures; via chronic treatment with nanomolar concentration of Abeta oligomers
|
| 88511 |
Amyloid beta peptide (42, oligomer)
|
|
increases_activity of
|
apoptotic process
|
intracellular in rat cortical neurons in culture and entorhinal-hippocampal organotypic slices; requiring NMDA and AMPA receptor activation
|
| 88519 |
AMPA receptor complex
|
|
increases_activity of
|
apoptotic process
|
in entorhinal cortex and hippocampal slice cultures; via chronic treatment with nanomolar concentration of Abeta oligomers
|
| 88521 |
mitochondrial depolarization
|
|
increases_activity of
|
apoptotic process
|
|
|
20061018
|
|
8,712
|
| 90776 |
decreased mir-98-5p level
|
|
decreases_activity of
|
apoptotic process
|
in SK-N-SH and SH-SY5Y cells; by upregulating SNX6 expression
|
|
27541017
|
|
8,846
|
| 92726 |
BCL2L11
|
|
increases_activity of
|
apoptotic process
|
as target of FOXOs
|
|
24832605
|
AlzNet-DB