|
1,107
|
| 79061 |
TGFB1
|
|
increases_activity of
|
amyloid-beta clearance
|
in transgenic AD-prone mice; if TGFBR1 is overexpressed
|
|
20462385
|
|
2,278
|
| 19543 |
PPARG
|
|
increases_activity of
|
amyloid-beta clearance
|
|
|
21345168
|
|
3,308
|
| 120756 |
A2M
|
|
increases_activity of
|
amyloid-beta clearance
|
by degradation of Abeta
|
|
9697696
|
|
3,792
|
| 37823 |
CD36
|
|
increases_activity of
|
amyloid-beta clearance
|
CD36 promotes the clearance and phagocytosis of Abeta.
|
| 37824 |
Class A scavenger receptor
|
|
increases_activity of
|
amyloid-beta clearance
|
SRA promotes the clearance and phagocytosis of Abeta.
|
|
19464758
|
|
7,598
|
| 77101 |
LRP1
|
|
affects_activity of
|
amyloid-beta clearance
|
|
| 77579 |
Oleuropein aglycone
|
|
increases_activity of
|
amyloid-beta clearance
|
|
| 77581 |
Oleocanthal
|
|
increases_activity of
|
amyloid-beta clearance
|
by upregulating two major transporters of Abeta expressed in the blood‚Äďbrain barrier;
|
|
27634977
|
|
7,871
|
| 78388 |
APOE (isoform E4)
|
|
decreases_activity of
|
amyloid-beta clearance
|
via lower levels of hippocampal insulin degrading enzyme
|
|
26708713
|
|
7,977
|
| 79065 |
APOE (lipid-depleted)
|
|
decreases_activity of
|
amyloid-beta clearance
|
|
|
23779114
|
|
8,619
|
| 89003 |
decreased SOAT1 level
|
|
increases_activity of
|
amyloid-beta clearance
|
in microglia
|
| 89006 |
microglia
|
|
increases_activity of
|
amyloid-beta clearance
|
in mouse microglia; via proteolytic clearance
|
|
25339759
|
|
8,658
|
| 89880 |
Estradiol
|
|
increases_activity of
|
amyloid-beta clearance
|
in Alzheimer
|
|
29559883
|
|
9,047
|
| 94596 |
APOE (isoform E4)
|
|
decreases_activity of
|
amyloid-beta clearance
|
from brain; concerning soluble Abeta, by promoting Abeta oligomer binding to synapses
|
|
27103636
|
|
9,069
|
| 94961 |
APOE (isoform E4)
|
|
decreases_activity of
|
amyloid-beta clearance
|
|
| 94965 |
aberrant endosomal lumen acidification
|
|
decreases_activity of
|
amyloid-beta clearance
|
in ApoE4 astrocytes; via trapping LRP1 within intracellular compartments
|
| 95043 |
endosomal lumen acidification
|
|
decreases_activity of
|
amyloid-beta clearance
|
concerning excessive endosomal acidification in ApoE4 astrocytes
|
| 140735 |
decreased SLC9A6 expression
|
|
decreases_activity of
|
amyloid-beta clearance
|
concerning excessive endosomal acidification in ApoE4 astrocytes
|
| 140736 |
SLC9A6
|
|
increases_activity of
|
amyloid-beta clearance
|
concerning excessive endosomal acidification in ApoE4 astrocytes
|
|
29946028
|
|
10,849
|
| 110851 |
LRP1
|
|
increases_activity of
|
amyloid-beta clearance
|
in astrocytes and pericyte; LRP1 mediates Abeta clearance
|
|
30804776
|
|
11,021
|
| 111867 |
APOE (isoform E4)
|
|
decreases_activity of
|
amyloid-beta clearance
|
Abeta clearance is decreased by the presence of ApoE4 expression
|
|
31130847
|
|
12,139
|
| 119066 |
APOE
|
|
affects_activity of
|
amyloid-beta clearance
|
|
| 119214 |
APOE (N- and C-termini truncated)
|
|
decreases_activity of
|
amyloid-beta clearance
|
in AD brain; promoting Abeta accumulation via lacking the Abeta transporter-binding domain
|
|
30850702
|
|
12,310
|
| 120617 |
decreased APOE level
|
|
increases_activity of
|
amyloid-beta clearance
|
in hamster ovarian cells; compared to cells secreting apoE2, apoE3, or apoE4 (EKO > E2 > E3 > E4; KO-cells with highest clearance)
|
| 124975 |
APOE (isoform E2)
|
|
increases_activity of
|
amyloid-beta clearance
|
in hamster ovarian cells; compared to cells secreting apoE3 or apoE4
|
| 124976 |
APOE (isoform E3)
|
|
increases_activity of
|
amyloid-beta clearance
|
in hamster ovarian cells; compared to cells secreting apoE4
|
| 124977 |
APOE (isoform E3)
|
|
decreases_activity of
|
amyloid-beta clearance
|
in hamster ovarian cells; compared to cells secreting apoE2
|
| 124978 |
APOE (isoform E4)
|
|
decreases_activity of
|
amyloid-beta clearance
|
in hamster ovarian cells; compared to cells secreting apoE2 and apoE3
|
|
23620513
|
|
12,651
|
| 122466 |
APOE4 (C-terminal-truncated fragment)
|
|
decreases_activity of
|
amyloid-beta clearance
|
via decreased Abeta peptides binding
|
|
21368138
|
|
12,867
|
| 123395 |
IDE
|
|
increases_activity of
|
amyloid-beta clearance
|
|
|
22962256
|
|
13,714
|
| 128906 |
IDE
|
|
increases_activity of
|
amyloid-beta clearance
|
via degradation of Abeta
|
|
28655134
|
|
13,729
|
| 128971 |
TOR signaling
|
|
decreases_activity of
|
amyloid-beta clearance
|
activated AMPK decreases mTOR signaling activity which facilitates autophagy and promotes lysosomal degradation of Abeta
|
| 129157 |
APOE lipidation
|
|
increases_activity of
|
amyloid-beta clearance
|
|
|
28655134
|
|
13,924
|
| 131625 |
tanycyte dysfunction
|
|
decreases_activity of
|
amyloid-beta clearance
|
in brain; via both impaired insulin synthesis and impaired insulin signaling
|
| 131626 |
abnormal pancreatic beta cell physiology
|
|
decreases_activity of
|
amyloid-beta clearance
|
via both impaired insulin synthesis and impaired insulin signaling
|
|
29797185
|
|
13,998
|
| 132229 |
A2M
|
|
increases_activity of
|
amyloid-beta clearance
|
through BBB
|
| 132248 |
perivascular pathway
|
|
increases_activity of
|
amyloid-beta clearance
|
in mouse
|
| 132258 |
ABCA1
|
|
increases_activity of
|
amyloid-beta clearance
|
not directly binding and extruding Abeta, but mediating Abeta clearance in an ApoE-dependent manner
|
| 132271 |
LRP2-CLU complex
|
|
increases_activity of
|
amyloid-beta clearance
|
through BBB; when LRP2 forms a complex with clusterin
|
| 132298 |
AQP4 KO mouse
|
|
decreases_activity of
|
amyloid-beta clearance
|
by 55‚Äď65%, compared with wild-type mice
|
|
26195256
|
|
14,963
|
| 140228 |
microglia
|
|
increases_activity of
|
amyloid-beta clearance
|
impaired in APP/PS1 mice
|
|
|
|
15,119
|
| 141700 |
SYNJ1
|
|
decreases_activity of
|
amyloid-beta clearance
|
in neuronal cells stably expressing mutant APP; concerning extracellular and intracellular clearance of Abeta
|
|
|
|
15,133
|
| 141826 |
APOE (isoform E4)
|
|
decreases_activity of
|
amyloid-beta clearance
|
in APOE knocked-out primary murine microglia; compared to APOE3 and APOE2, concerning the clearance of soluble extracellular Abeta through lysosomal degradation
|
| 141946 |
APOE (isoform E3)
|
|
increases_activity of
|
amyloid-beta clearance
|
in APOE knocked-out primary murine microglia; compared to APOE4, concerning the clearance of soluble extracellular Abeta through lysosomal degradation
|
| 141947 |
APOE (isoform E2)
|
|
increases_activity of
|
amyloid-beta clearance
|
in APOE knocked-out primary murine microglia; compared to APOE4, concerning the clearance of soluble extracellular Abeta through lysosomal degradation
|
| 141998 |
MME
|
|
affects_activity of
|
amyloid-beta clearance
|
|
| 142181 |
APOE
|
|
increases_activity of
|
amyloid-beta clearance
|
by microglia ; in an isoform-dependent manner
|
|
|
|
15,211
|
| 142748 |
PICALM-mut
|
|
increases_activity of
|
amyloid-beta clearance
|
across the BBB
|
| 143427 |
PICALM
|
|
affects_activity of
|
amyloid-beta clearance
|
across the BBB; validated AD risk factor
|
| 143429 |
PICALM rs3851179
|
|
decreases_activity of
|
amyloid-beta clearance
|
in an in vitro model of the BBB; non-protective allele, validated AD risk factor
|
| 143432 |
CLU
|
|
increases_activity of
|
amyloid-beta clearance
|
across the BBB
|
|
|
|
15,250
|
| 143794 |
LRP1
|
|
increases_activity of
|
amyloid-beta clearance
|
|
| 143795 |
ABCB1
|
|
increases_activity of
|
amyloid-beta clearance
|
|
| 143893 |
LRP2
|
|
increases_activity of
|
amyloid-beta clearance
|
from the CNS
|
| 143894 |
ABCC1
|
|
increases_activity of
|
amyloid-beta clearance
|
from the CNS
|
| 143895 |
ABCG2
|
|
increases_activity of
|
amyloid-beta clearance
|
from the CNS
|
| 143896 |
ABCG4
|
|
increases_activity of
|
amyloid-beta clearance
|
from the CNS
|
| 143897 |
FCGRT
|
|
increases_activity of
|
amyloid-beta clearance
|
from the CNS
|
| 143920 |
decreased ABCB1 activity
|
|
decreases_activity of
|
amyloid-beta clearance
|
in brain
|
|
|
|
15,259
|
| 144251 |
LRP1
|
|
increases_activity of
|
amyloid-beta clearance
|
in normal brain; with LRP1 localized on endothelial cell
|
| 144252 |
ABCB1
|
|
increases_activity of
|
amyloid-beta clearance
|
in normal brain; with P-GP localized on endothelial cell
|
|
|
|
15,322
|
| 145013 |
autophagy
|
|
increases_activity of
|
amyloid-beta clearance
|
|
|
|
|
15,347
|
| 145116 |
autophagy
|
|
increases_activity of
|
amyloid-beta clearance
|
via decreasing APP-CTFs
|
|
|
AlzNet-DB