|
2,782
|
| 25721 |
alternative mRNA splicing, via spliceosome
|
|
affects_activity of
|
MAPT
|
via alternative splicing of tau exon 10; resulting in different microtubule-binding repeats in TAU protein;
|
| 25732 |
alternative mRNA splicing, via spliceosome
|
|
affects_activity of
|
TRA2B1
|
|
| 25742 |
alternative mRNA splicing, via spliceosome
|
|
affects_activity of
|
PSEN2
|
|
| 25743 |
alternative mRNA splicing, via spliceosome
|
|
affects_activity of
|
CLK2
|
|
| 25744 |
TRA2B1
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
of TAU exon 10
|
| 25747 |
CLK2
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
of TAU exon 10
|
| 25780 |
Alzheimer disease
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
|
| 25785 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
MAPT-var (4R)
|
= TAU isoform containing four microtubule-binding repeats
with (4R) or without exon 10 (3R).
|
| 25786 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
TRA2B1
|
|
| 25787 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
CLK2-var (inactive)
|
|
| 25788 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
PSEN2-var
|
|
|
16371011
|
|
2,804
|
| 25871 |
SRSF2
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
of MAPT/TAU exon 10
|
| 25892 |
MAPT-mut (enhancer)
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
of MAPT / TAU exon 10
|
|
21470964
|
|
2,811
|
| 25925 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
MAPT-var (3R)
|
TAU (3R) = TAU isoform containing three microtubule-binding repeats.
|
| 25926 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
MAPT-var (4R)
|
TAU (4R) = TAU isoform containing four microtubule-binding repeats.
|
|
21281635
|
|
2,828
|
| 26118 |
PRKACA
|
|
increases_activity of
|
alternative mRNA splicing, via spliceosome
|
of TAU exon 10
|
| 26119 |
SRSF1
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
of TAU exon 10
|
|
21367856
|
|
2,873
|
| 26469 |
MAPT-mut
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
resulting in excess exon 10 (E10) inclusion.
|
|
19498037
|
|
2,893
|
| 26606 |
RBM4
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
|
|
16777844
|
|
2,903
|
| 26652 |
SRSF2
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
of tau exon 10
|
|
21333649
|
|
2,909
|
| 26675 |
alternative mRNA splicing, via spliceosome
|
|
affects_activity of
|
Tauopathy
|
|
| 26684 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
MAPT-var (4R)
|
|
| 26685 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
MAPT-var (3R)
|
|
| 26752 |
SRSF2-phos
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
|
|
20615469
|
|
2,970
|
| 27048 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
MAPT-var
|
neuron-specific tau transcript produces multiple isoforms
|
| 27050 |
alternative mRNA splicing, via spliceosome
|
|
affects_activity of
|
neurodegeneration
|
e.g. aberrations in tau splicing regulation increase neurodegenerative diseases
|
|
15615629
|
|
2,985
|
| 27194 |
DDX5
|
|
increases_activity of
|
alternative mRNA splicing, via spliceosome
|
|
| 27203 |
RBM4
|
|
affects_activity of
|
alternative mRNA splicing, via spliceosome
|
|
|
21343338
|
|
3,178
|
| 95725 |
alternative mRNA splicing, via spliceosome
|
|
affects_activity of
|
MAPT
|
concerning mutations of MAPT exon10
|
|
16230627
|
|
8,772
|
| 91271 |
sex, female
|
|
increases_activity of
|
alternative mRNA splicing, via spliceosome
|
in AD female brains; concerning the alternative splicing of ERalpha mRNA
|
| 124739 |
Alzheimer disease
|
|
decreases_activity of
|
alternative mRNA splicing, via spliceosome
|
in AD female brains; concerning the alternative splicing of ERalpha mRNA
|
| 124740 |
female brain
|
|
increases_activity of
|
alternative mRNA splicing, via spliceosome
|
in AD female brains; concerning the alternative splicing of ERalpha mRNA
|
|
20417581
|
|
8,907
|
| 92994 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP-var
|
in mammals; due to alternative splicing of three exons 7, 8, and 15
|
| 93474 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP770
|
in humans; includes KPI, OX2, and exon 15
|
| 93475 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP751
|
in humans; includes KPI and exon 15, without OX2
|
| 93476 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP714
|
in humans; without KPI, includes OX2 and exon 15
|
| 93477 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP695
|
in humans; without KPI, without OX2, with exon 15
|
| 93478 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP752
|
in humans; includes KPI and OX2, without exon 15
|
| 93479 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP733
|
in humans; includes KPI, without OX2, without exon 15
|
| 93480 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP696
|
in humans; without KPI, includes OX2, without exon 15
|
| 93481 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP677
|
in humans; without KPI, without OX2, without exon 15
|
| 93482 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APLP2-763
|
in humans; with 12aa exon
|
| 93483 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APLP2-707
|
in humans; with 12aa exon
|
| 93484 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APLP2-751
|
in humans; without 12aa exon
|
| 93485 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APLP2-695
|
in humans; without 12aa exon
|
|
8624099
|
|
8,946
|
| 93486 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP-var
|
in mammals; due to alternative splicing of three exons 7, 8, and 15
|
| 93487 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP770
|
in rat; includes KPI, OX2, and exon 15
|
| 93488 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP751
|
in rat; includes KPI and exon 15, without OX2
|
| 93489 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP714
|
in rat; without KPI, includes OX2 and exon 15
|
| 93490 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP695
|
in rat; without KPI, without OX2, with exon 15
|
| 93491 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP752
|
in rat; includes KPI and OX2, without exon 15
|
| 93492 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP733
|
in rat; includes KPI, without OX2, without exon 15
|
| 93493 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP696
|
in rat; without KPI, includes OX2, without exon 15
|
| 93494 |
alternative mRNA splicing, via spliceosome
|
|
increases_quantity of
|
APP677
|
in rat; without KPI, without OX2, without exon 15
|
|
8624099
|
|
9,697
|
| 102322 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
LEPRa
|
concerning alternative splicing during LepR-coding db gene expression; resulting in six different LepR isoforms (LepRa-f)
|
| 102375 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
LEPRb
|
concerning alternative splicing during LepR-coding db gene expression; resulting in six different LepR isoforms (LepRa-f)
|
| 102376 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
LEPRc
|
concerning alternative splicing during LepR-coding db gene expression; resulting in six different LepR isoforms (LepRa-f)
|
| 102377 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
LEPRd
|
concerning alternative splicing during LepR-coding db gene expression; resulting in six different LepR isoforms (LepRa-f)
|
| 102378 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
LEPRe
|
concerning alternative splicing during LepR-coding db gene expression; resulting in six different LepR isoforms (LepRa-f)
|
| 102379 |
alternative mRNA splicing, via spliceosome
|
|
affects_quantity of
|
LEPRf
|
concerning alternative splicing during LepR-coding db gene expression; resulting in six different LepR isoforms (LepRa-f)
|
|
30692905
|
AlzNet-DB