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Expression experiments of cluster mir-106b-25 (existing of mir-106b, mir-93, and mir-25, located in intron 13 of gene MCM7) strongly suggests that miR-106b-25 transcription in gastric tumors is driven by its host gene, Mcm7.
The authors provide evidence that miR-106b-25 cluster, activated by E2F1 and upregulated in human gastric adenocarcinomas, alters the physiological response of gastric cancer cells to TGF?, affecting both cell-cycle arrest and apoptosis (Figure 8). These findings are of particular relevance in a gastric cancer model, as impairment of the TGF? tumor suppressor pathway is a critical step in the development of gastric tumors.