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General information


98
18328430
Homo sapiens (9606)
disease
Gastric cancer

Study information


Patient study phenotype-control
20
20
stomach

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-100 miRNA microarray miRNA overexpression 2.1
2 hsa-mir-103-1 miRNA microarray miRNA overexpression 2.5
3 hsa-mir-106a miRNA microarray miRNA overexpression 2.8
4 hsa-mir-106b miRNA microarray miRNA overexpression 2 CDKN1A
5 hsa-mir-107 miRNA microarray miRNA overexpression 2.7
6 hsa-mir-125b-1 miRNA microarray miRNA overexpression 3.6
7 hsa-mir-136 miRNA microarray miRNA downregulation 1.67
8 hsa-mir-17 miRNA microarray miRNA overexpression 3.7
9 hsa-mir-181b-1 miRNA microarray miRNA overexpression 3.4
10 hsa-mir-21 miRNA microarray miRNA overexpression 4.5
11 hsa-mir-212 miRNA microarray miRNA downregulation 1.67
12 hsa-mir-218-1 miRNA microarray miRNA downregulation 1.67
13 hsa-mir-221 miRNA microarray miRNA overexpression 2.4
14 hsa-mir-223 miRNA microarray miRNA overexpression 4.2
15 hsa-mir-25 miRNA microarray miRNA overexpression 3.8 BCL2L11
16 hsa-mir-339 miRNA microarray miRNA downregulation 1.43
17 hsa-mir-92a-1 miRNA microarray miRNA overexpression 2.5
18 hsa-mir-93 miRNA microarray miRNA overexpression 2.3 CDKN1A
19 hsa-mir-96 miRNA microarray miRNA downregulation 1.43

Detailed information about selected miRNA


hsa-mir-100
miRNA microarray
miRNA overexpression
2.1    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: Expression experiments of cluster mir-106b-25 (existing of mir-106b, mir-93, and mir-25, located in intron 13 of gene MCM7) strongly suggests that miR-106b-25 transcription in gastric tumors is driven by its host gene, Mcm7. The authors provide evidence that miR-106b-25 cluster, activated by E2F1 and upregulated in human gastric adenocarcinomas, alters the physiological response of gastric cancer cells to TGF?, affecting both cell-cycle arrest and apoptosis (Figure 8). These findings are of particular relevance in a gastric cancer model, as impairment of the TGF? tumor suppressor pathway is a critical step in the development of gastric tumors.