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General information


94
18429962
Homo sapiens (9606)
disease
Cancer
Thyroid carcinoma, anaplastic

Study information


Cell culture study
anaplastic thyroid cancer cell line
In the study ARO cells (a human anaplastic thyroid cancer cell line) and, as control, primary thyrocytes (PT) were compared in microarray experiments. Results were confirmed by analysis of FRO cells (a human anaplastic thyroid cancer cell line).

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-100 miRNA microarray miRNA downregulation 5.26
2 hsa-mir-106a miRNA microarray miRNA overexpression 2.2
3 hsa-mir-106b miRNA microarray miRNA overexpression 3.26
4 hsa-mir-10a miRNA microarray miRNA overexpression 5.7
5 hsa-mir-125b-1 miRNA microarray miRNA downregulation 20
6 hsa-mir-138-1 miRNA microarray miRNA downregulation 12.5
7 hsa-mir-143 miRNA microarray miRNA downregulation 1.67
8 hsa-mir-145 miRNA microarray miRNA downregulation 1.43
9 hsa-mir-148a miRNA microarray miRNA downregulation 5.26
10 hsa-mir-16-1 miRNA microarray miRNA overexpression 5.27
11 hsa-mir-17 miRNA microarray Northern Blot miRNA overexpression 2.25 RB1
12 hsa-mir-18a miRNA microarray Northern Blot miRNA overexpression 1.46
13 hsa-mir-192 miRNA microarray miRNA overexpression 16.53
14 hsa-mir-194-1 miRNA microarray miRNA overexpression 9.14
15 hsa-mir-196a-1 miRNA microarray miRNA overexpression 11.95
16 hsa-mir-199a-1 miRNA microarray miRNA downregulation 4
17 hsa-mir-19a miRNA microarray Northern Blot miRNA overexpression 1.29
18 hsa-mir-19b-1 miRNA microarray Northern Blot miRNA overexpression 2.12
19 hsa-mir-200b miRNA microarray miRNA overexpression 6.28
20 hsa-mir-20a miRNA microarray Northern Blot miRNA overexpression 3.37
21 hsa-mir-210 miRNA microarray miRNA downregulation 2.5
22 hsa-mir-221 miRNA microarray miRNA downregulation 1.96
23 hsa-mir-222 miRNA microarray miRNA downregulation 2.5
24 hsa-mir-23a miRNA microarray miRNA downregulation 2.94
25 hsa-mir-24-1 miRNA microarray miRNA downregulation 3.33
26 hsa-mir-27a miRNA microarray miRNA downregulation 3.33
27 hsa-mir-429 miRNA microarray miRNA overexpression 6.69
28 hsa-mir-7-1 miRNA microarray miRNA overexpression 6.18
29 hsa-mir-92a-1 miRNA microarray Northern Blot miRNA overexpression 1.38

Detailed information about selected miRNA


hsa-mir-100
miRNA microarray
miRNA downregulation
5.26    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: The present work shows significant discrepancies between cell culture results and patient results. Contrary the findings presented here, Visone et al. (PMID: 17563749) have recently reported that no miR was overexpressed in 10 human ATC samples using microarray technique.