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In the study ARO cells (a human anaplastic thyroid cancer cell line) and, as control, primary thyrocytes (PT) were compared in microarray experiments. Results were confirmed by analysis of FRO cells (a human anaplastic thyroid cancer cell line).
The present work shows significant discrepancies between cell culture results and patient results. Contrary the findings presented here, Visone et al. (PMID: 17563749) have recently reported that no miR was overexpressed in 10 human ATC samples using microarray technique.