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General information

Homo sapiens (9606)
Gastric cancer

Study information

Cell culture study
microRNA expression profiling revealed a limited set of microRNAs with altered expression in multidrug- resistant gastric cancer cell line SGC7901/VCR compared to its parental SGC7901 cell line. It was shown that 10 of 342 human miRNAs examined were downregulated more than 2-fold in SGC7901/VCR cells compared to SGC7901 cells. In contrast, only 2 miRNAs were upregulated more than 2-fold in SGC7901/VCR cells.
SGC-7901 cell

miRNA list

Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-let-7a-1 miRNA microarray miRNA downregulation
2 hsa-mir-106a miRNA microarray miRNA downregulation
3 hsa-mir-106b miRNA microarray miRNA downregulation
4 hsa-mir-15b miRNA microarray quantitative PCR miRNA downregulation BCL2
5 hsa-mir-16-1 miRNA microarray quantitative PCR miRNA downregulation BCL2
6 hsa-mir-17 miRNA microarray miRNA downregulation
7 hsa-mir-196a-1 miRNA microarray miRNA downregulation
8 hsa-mir-20a miRNA microarray miRNA downregulation
9 hsa-mir-23b miRNA microarray miRNA downregulation
10 hsa-mir-302b miRNA microarray miRNA overexpression
11 hsa-mir-320a miRNA microarray miRNA downregulation
12 hsa-mir-492 miRNA microarray miRNA overexpression

Detailed information about selected miRNA

Authors' designation: hsa-miR-let-7a;
miRNA microarray
miRNA downregulation

Genes associated with selected miRNA

target gene regulation mechanism of regulation comment


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