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General information


90
18176954
Homo sapiens (9606)
disease
Hepatocellular carcinoma

Study information


Patient study phenotype-phenotype
Phenotype 1: primary HCC (hepatocellular carcinoma) with venous metastases (n=29); Phenotype 2: HCC from metastasis-free solitary tumors (n=102);
liver
In contrast to HCC staging systems, this 20-miRNA signature was capable of predicting survival and recurrence of HCC in patients with multinodular or solitary tumors, including those with early-stage disease.

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-let-7g miRNA microarray miRNA downregulation 1.45
2 hsa-mir-1-2 miRNA microarray miRNA downregulation 1.96
3 hsa-mir-122 miRNA microarray miRNA downregulation 1.67
4 hsa-mir-124-2 miRNA microarray miRNA downregulation 1.89
5 hsa-mir-125b-2 miRNA microarray miRNA downregulation 1.72
6 hsa-mir-126 miRNA microarray miRNA downregulation 1.75
7 hsa-mir-148a miRNA microarray miRNA downregulation 2
8 hsa-mir-148b miRNA microarray miRNA downregulation 1.85
9 hsa-mir-15a miRNA microarray miRNA downregulation 1.56
10 hsa-mir-185 miRNA microarray miRNA overexpression 1.33
11 hsa-mir-194-1 miRNA microarray miRNA downregulation 1.69
12 hsa-mir-19a miRNA microarray miRNA downregulation 1.79
13 hsa-mir-219-1 miRNA microarray miRNA overexpression 1.48
14 hsa-mir-30a miRNA microarray miRNA downregulation 1.56
15 hsa-mir-30c-1 miRNA microarray miRNA downregulation 2
16 hsa-mir-30e miRNA microarray miRNA downregulation 1.59
17 hsa-mir-338 miRNA microarray miRNA overexpression 1.42
18 hsa-mir-34a miRNA microarray miRNA downregulation 2.08
19 hsa-mir-9-2 miRNA microarray miRNA downregulation 1.75

Detailed information about selected miRNA


hsa-let-7g
miRNA microarray
miRNA downregulation
1.45    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: The fourth mentioned overexpressed miRNA, mir-207 could not be found for human.