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General information


672
20888417
Homo sapiens (9606)
disease
Alzheimer disease

Study information


Patient study phenotype-control
16
brain

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-17 quantitative PCR miRNA overexpression 10 - 10 GABBR2

Detailed information about selected miRNA


hsa-mir-17
Authors' designation: ncRNA 17A
quantitative PCR
miRNA overexpression
10   -   10

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment
GABBR2 up 17A, a non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease. The stable expression of 17A in SHSY5Y neuroblastoma cells induces the synthesis of an alternative splicing isoform that abolish GABA B2 intracellular signaling (i.e., inhibition of cAMP accumulation and activation of K+ channels).

Comments


General comment: In RT-PCR experiments, the levels of expression of ncRNA 17A in autoptic brain samples from 16 Alzheimer disease patients were checked. An averaged 10.0-fold increased level of 17A synthesis was detected.