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General information


663
20202123
Homo sapiens (9606)
disease
Alzheimer disease

Study information


Patient study phenotype-control
7
14
Seven AD patients composed of four men and three women with the mean age of 69.1 +- 9.2 years, and 14 non-AD patients composed of eight men and six women with the mean age of 73.1 +- 10.1 years.
brain

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-29a miRNA microarray miRNA downregulation NAV3

Detailed information about selected miRNA


hsa-mir-29a
The expression of miR-29a is reduced in the frontal cortex of AD.
miRNA microarray
miRNA downregulation
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment
NAV3 down

Comments


General comment: MiR-29a-mediated down-regulation of NAV3 was verified by the luciferase reporter assay