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General information


651
19843690
Mus musculus (10090)
disease
Asthma

Study information


Patient study phenotype-control
Naive wild-type (WT) BALB/c mice were exposed to a single dose of HDM (house dust mite) by directly instilling the allergen into the airways, and the expression of miRNAs in the airway wall at 6, 12, and 24 h after challenge was characterized.
trachea

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 mmu-mir-126 miRNA microarray quantitative PCR miRNA overexpression 2 POU2AF1
2 mmu-mir-16-1 miRNA microarray quantitative PCR miRNA overexpression 2
3 mmu-mir-21 miRNA microarray quantitative PCR miRNA overexpression 2

Detailed information about selected miRNA


mmu-mir-126
miRNA microarray
quantitative PCR
miRNA overexpression
2    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment
POU2AF1 down The increase in OBF.1/BOB.1 expression by ant-miR-126 treatment resulted in high expression of transcripts that code for Ig chains and are likely to be derived from plasma cells that infiltrate the airways wall during allergic airways inflammation.

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