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Naive wild-type (WT) BALB/c mice were exposed to a single dose of HDM (house dust mite) by directly instilling the allergen into the airways, and the expression of miRNAs in the airway wall at 6, 12, and 24 h after challenge was characterized.
The increase in OBF.1/BOB.1 expression by ant-miR-126 treatment resulted in high expression of transcripts that code for Ig chains and are likely to be derived from plasma cells that infiltrate the airways wall during allergic airways inflammation.