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General information


650
19931339
Homo sapiens (9606)
disease
Rheumatoid arthritis

Study information


Patient study phenotype-control
Experiments were done in sorted CD3+, CD4+ and CD8+ lymphocytes of patients with active RA (Rheumatoid arthritis) and healthy control subjects.
blood

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-223 miRNA microarray quantitative PCR miRNA overexpression

Detailed information about selected miRNA


hsa-mir-223
miR-223 is predominantly expressed in CD4+ cells..
miRNA microarray
quantitative PCR
miRNA overexpression
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: CD4+ cells have been highlighted previously as key players in RA pathology. It is therefore of interest that this subpopulation seems to be responsible for most of the miR-223 measured within the CD3+ cells of RA patients.