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General information


637
19351747
Homo sapiens (9606)
disease
Squamous cell carcinoma, head and neck

Study information


Patient study phenotype-control
16
5
epithelium
Primary tumors and non-diseased head and neck epithelial tissues were analysed.

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-130b miRNA microarray miRNA overexpression 4.17
2 hsa-mir-181a-1 miRNA microarray miRNA overexpression 2.11
3 hsa-mir-181b-1 miRNA microarray miRNA overexpression 2.97
4 hsa-mir-181d miRNA microarray miRNA overexpression 2.86
5 hsa-mir-18a miRNA microarray quantitative PCR miRNA overexpression 2.78
6 hsa-mir-18b miRNA microarray miRNA overexpression 2.5
7 hsa-mir-193b miRNA microarray miRNA overexpression 3.44
8 hsa-mir-21 miRNA microarray quantitative PCR miRNA overexpression 3.67
9 hsa-mir-221 miRNA microarray quantitative PCR miRNA overexpression 2.26
10 hsa-mir-375 miRNA microarray quantitative PCR miRNA downregulation 21.88
11 hsa-mir-455 miRNA microarray miRNA overexpression 2.58
12 hsa-mir-491 miRNA microarray miRNA overexpression 5.08

Detailed information about selected miRNA


hsa-mir-130b
miRNA microarray
miRNA overexpression
4.17    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: The results indicate that miR-221 and miR-375 should be evaluated further as diagnostic biomarkers, as they may hold utility in defining broadly responsive prevention and treatment strategies for HNSCC.